Results 91 to 100 of about 738,909 (270)

AutoShrink: A Topology-Aware NAS for Discovering Efficient Neural Architecture

open access: yesProceedings of the AAAI Conference on Artificial Intelligence, 2020
Resource is an important constraint when deploying Deep Neural Networks (DNNs) on mobile and edge devices. Existing works commonly adopt the cell-based search approach, which limits the flexibility of network patterns in learned cell structures. Moreover, due to the topology-agnostic nature of existing works, including both cell-based and node-based ...
Zhang, Tunhou   +6 more
openaire   +3 more sources

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Deep Neural Networks - A Brief History

open access: yes, 2017
Introduction to deep neural networks and their history.Comment: 14 pages, 14 ...
AL Hodgkin   +13 more
core   +1 more source

DC-NAS: Divide-and-Conquer Neural Architecture Search

open access: yes, 2020
Most applications demand high-performance deep neural architectures costing limited resources. Neural architecture searching is a way of automatically exploring optimal deep neural networks in a given huge search space. However, all sub-networks are usually evaluated using the same criterion; that is, early stopping on a small proportion of the ...
Wang, Yunhe, Xu, Yixing, Tao, Dacheng
openaire   +2 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Design and implementation of an electronic architecture for an agricultural mobile robot Projeto e implementação de uma arquitetura eletrônica para um robô agrícola móvel

open access: yesRevista Brasileira de Engenharia Agrícola e Ambiental, 2010
A current trend in the agricultural area is the development of mobile robots and autonomous vehicles for remote sensing. One of the major challenges in the design of these robots is the development of the electronic architecture for the integration and ...
Eduardo P. Godoy   +5 more
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

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