Results 111 to 120 of about 45,891 (308)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Quantitative Assessment of Soil Salinity Using Electromagnetic Induction Technique and Geostatistical Approach [PDF]

, 2017
Not AvailableAssessment and monitoring of soil salinity is prerequisite for proper and timely decisions on reclamation and management of saline soil. Electromagnetic induction (EMI) method could be a cost effective and rapid method for assessment of ...
SK Kamra, Neeraj Kumar, Ramesh Abhishek, Satyendra Kumar, Parveen Kumar, Pardeep Jangra, Bhaskar Narjary, K Thimappa, RL Meena, R Raju, AR Chichmatalpure   +10 more
core  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Calibration, validation and application of foraminiferal carbonate based proxies. Reconstructing temperature, salinity and sea water Mg/Ca

, 2012
The chemistry of the calcite test of foraminifera is often relating to the environmental conditions under which they lived. These so-called proxy-relations are regularly used as a tool to reconstruct past climates.
Organic geochemistry, Wit, J.C., Biological validation of proxies for temperature, salinity, oxygenation and pCO2 based on experimental evidence using benthic foraminiferal cultures   +2 more
core  

Salinity-Driven Structural and Viscosity Modulation of Confined Polar Oil Phases by Carbonated Brine Films: Novel Insights from Molecular Dynamics

The structural and dynamic properties of fluids under confinement in a porous medium differ from their bulk properties. This study delves into the surface structuring and hydrodynamic characteristics of oil/thin film carbonated brine two-phase within ...
Riyaz Kharrat (7401020), Vahid Niasar (9425034), Holger Ott (2389489), Ali Mirzaalian Dastjerdi (17940739)   +3 more
core   +1 more source

The response of barley to salinity stress differs between hydroponics and soil systems

, 2010
Many studies on salinity stress assume that responses in hydroponics mimic those in soil. However, interactions between the soil solution and the soil matrix can affect responses to salinity stress.
Tavakkoli, Ehsan, Rengasamy, Pichu, Pichu Rengasamy, McDonald, G., Glenn K. McDonald, McDonald, Glenn, Tavakkoli, E., Rengasamy, P., Ehsan Tavakkoli   +8 more
core   +1 more source

Serum osmolality and ions, and gill Na+/K+-ATPase of spottedtail goby Synechogobius ommaturus (R.) in response to acute salinity changes

Aquaculture and Fisheries, 2018
This study was carried out to determine the effects of abrupt salinity change on osmoregulatory ability of the spottedtail goby Synechogobius ommaturus.
Chun Shui, Yonghai Shi, Xueming Hua, Zhonghua Zhang, Haiming Zhang, Genhai Lu, Yongde Xie   +6 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source