Nanoenabled Intracellular Metal Ion Homeostasis Regulation for Tumor Therapy [PDF]
Advanced ScienceEndogenous essential metal ions play an important role in many life processes, especially in tumor development and immune response. The approval of various metallodrugs for tumor therapy brings more attention to the antitumor effect of metal ions.
Lihua Xu +8 more
doaj +3 more sources
How do plants maintain pH and ion homeostasis under saline-alkali stress?
Frontiers in Plant Science, 2023 Salt and alkaline stresses often occur together, severely threatening plant growth and crop yields. Salt stress induces osmotic stress, ionic stress, and secondary stresses, such as oxidative stress.
Jing Li, Yongqing Yang
doaj +3 more sources
DYSREGULATION OF ION HOMEOSTASIS BY ANTIFUNGAL AGENTS [PDF]
Frontiers in Microbiology, 2012 Ion signaling and transduction networks are central to fungal development and virulence because they regulate gene expression, filamentation, host association and invasion, pathogen stress response and survival.
Yongqiang eZhang +2 more
doaj +3 more sources
Targeting ion homeostasis in metabolic diseases: Molecular mechanisms and targeted therapies
Pharmacological ResearchThe incidence of metabolic diseases—hypertension, diabetes, obesity, metabolic dysfunction-associated steatotic liver disease (MASLD), and atherosclerosis—is increasing annually, imposing a significant burden on both human health and the social economy ...
Yanjiao Zhang +6 more
doaj +3 more sources
Ion channels and ion homeostasis in the platelet and megakaryocyte [PDF]
Platelets, 2021 The lipid bilayer of surface and organellar cell membranes represents a barrier to simple diffusion of inorganic ions or other charged molecules between extracellular and intracellular fluid compar...
Kirk A. Taylor, Martyn P. Mahaut-Smith
doaj +3 more sources
Adaptive metabolic rewiring and ion homeostasis enhance oxidative stress resistance in Lacticaseibacillus casei [PDF]
Applied and Environmental MicrobiologyEnhancing the oxidative stress tolerance of microorganisms is critical for maintaining their viability and functionality in industrial fermentation under aerobic conditions.
Lei Su +6 more
doaj +2 more sources
Melatonin Supplementation Relieves Fluoride-Induced Bone Injury via Ion Homeostasis Disorder and PINK1/Parkin-Mediated Mitophagy [PDF]
FoodsLong-term excessive fluoride intake from food causes skeletal fluorosis, which manifests as bone sclerosis, deformation, joint dysfunction, and even disability. Mitophagy and ion homeostasis regulate bone function.
Cuicui Zhuang +8 more
doaj +2 more sources
Advanced Science, 2019 Perturbation of potassium homeostasis can affect various cell functions and lead to the onset of programmed cell death. Although ionophores have been intensively used as an ion homeostasis disturber, the mechanisms of cell death are unclear and the ...
DaeYong Lee +10 more
doaj +2 more sources
Identification and analysis of prognostic ion homeostasis characteristics in kidney renal clear cell carcinoma [PDF]
HeliyonKidney renal clear cell carcinoma (KIRC), a prevalent primary malignant tumor within the urinary system, is characterized by significant heterogeneity. It has been shown that ion channels are important targets for anti-tumor therapy.
Xiangmin Zhang +5 more
doaj +2 more sources
Ultrasound-actuated ion homeostasis perturbator for oxidative damage-augmented Ca2+ interference therapy and combined immunotherapy [PDF]
Materials Today BioCalcium ion therapy has shown promise for cancer treatment, but its efficacy is limited by the cellular calcium buffering mechanism. Herein, an ion homeostasis disruptor (PCCa) was synthesized using an in situ mineralization method.
Mi Yang +6 more
doaj +2 more sources