Nanoenabled Intracellular Metal Ion Homeostasis Regulation for Tumor Therapy
Advanced ScienceEndogenous essential metal ions play an important role in many life processes, especially in tumor development and immune response. The approval of various metallodrugs for tumor therapy brings more attention to the antitumor effect of metal ions.
Lihua Xu +8 more
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Identification of ion homeostasis-related genes as diagnostic biomarkers for pulmonary arterial hypertension via WGCNA and machine learning [PDF]
Frontiers in GeneticsBackgroundPulmonary arterial hypertension (PAH) is a severe cardiovascular disease, with early diagnosis being difficult. Ion homeostasis imbalance contributes to PAH pathogenesis, but the systemic regulatory network involving ion homeostasis-related ...
Yang Chen, Qiu Chen, Senzhong Zheng
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Targeting ion homeostasis in metabolic diseases: Molecular mechanisms and targeted therapies
Pharmacological ResearchThe incidence of metabolic diseases—hypertension, diabetes, obesity, metabolic dysfunction-associated steatotic liver disease (MASLD), and atherosclerosis—is increasing annually, imposing a significant burden on both human health and the social economy ...
Yanjiao Zhang +6 more
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Advanced Science, 2019 Perturbation of potassium homeostasis can affect various cell functions and lead to the onset of programmed cell death. Although ionophores have been intensively used as an ion homeostasis disturber, the mechanisms of cell death are unclear and the ...
DaeYong Lee +10 more
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Melatonin Supplementation Relieves Fluoride-Induced Bone Injury via Ion Homeostasis Disorder and PINK1/Parkin-Mediated Mitophagy [PDF]
FoodsLong-term excessive fluoride intake from food causes skeletal fluorosis, which manifests as bone sclerosis, deformation, joint dysfunction, and even disability. Mitophagy and ion homeostasis regulate bone function.
Cuicui Zhuang +8 more
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Adaptive metabolic rewiring and ion homeostasis enhance oxidative stress resistance in Lacticaseibacillus casei [PDF]
Applied and Environmental MicrobiologyEnhancing the oxidative stress tolerance of microorganisms is critical for maintaining their viability and functionality in industrial fermentation under aerobic conditions.
Lei Su +6 more
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Identification and analysis of prognostic ion homeostasis characteristics in kidney renal clear cell carcinoma [PDF]
HeliyonKidney renal clear cell carcinoma (KIRC), a prevalent primary malignant tumor within the urinary system, is characterized by significant heterogeneity. It has been shown that ion channels are important targets for anti-tumor therapy.
Xiangmin Zhang +5 more
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Ultrasound-actuated ion homeostasis perturbator for oxidative damage-augmented Ca2+ interference therapy and combined immunotherapy [PDF]
Materials Today BioCalcium ion therapy has shown promise for cancer treatment, but its efficacy is limited by the cellular calcium buffering mechanism. Herein, an ion homeostasis disruptor (PCCa) was synthesized using an in situ mineralization method.
Mi Yang +6 more
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Frontiers in Cellular Neuroscience, 2023 How do neurons that implement cell-autonomous self-regulation of calcium react to knockout of individual ion-channel conductances? To address this question, we used a heterogeneous population of 78 conductance-based models of hippocampal pyramidal ...
Sunandha Srikanth +2 more
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How do plants maintain pH and ion homeostasis under saline-alkali stress?
Frontiers in Plant Science, 2023 Salt and alkaline stresses often occur together, severely threatening plant growth and crop yields. Salt stress induces osmotic stress, ionic stress, and secondary stresses, such as oxidative stress.
Jing Li, Yongqing Yang
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