Results 81 to 90 of about 45,891 (308)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Spinach Plants Favor the Absorption of K⁺ over Na⁺ Regardless of Salinity, and May Benefit from Na⁺ When K⁺ is Deficient in the Soil

Plants, 2020
Two spinach (Spinacea oleracea L.) cultivars were evaluated for their response to deficient (0.25 mmolc L−1 or 0.25 K) and sufficient (5.0 mmolc L−1 or 5.0 K) potassium (K) levels combined with salinities of 5, 30, 60, 90, and 120 mmolc L−1 NaCl.
Jorge F. S. Ferreira, Jaime Barros da Silva Filho, Xuan Liu, Devinder Sandhu   +3 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Solid humic substance enhanced spinach abiotic stress tolerance under combined drought, salinity, and daily heat stress

Plant Stress
Spinach is a crop of economic importance in the Wintergarden region of Texas, where increasing soil salinity, irrigation water restrictions, and heat stress challenge its production.
Seunghyun Choi, Joshua T. Harvey, Daniel I. Leskovar   +2 more
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Amelioration of salinity toxicity in South African crop plants with special reference to maize

, 1992
Bibliography: leaves 87-101.The effects of ammonium and nitrate nutrition on potassium uptake, photosynthetic gas exchange and growth responses to salinity stress (80 mM) together with the ameliorative roles of three ranges of calcium concentrations (2.5
Tshivhandekano, Thivhulawi Robert
core  

Reduction of photosynthetic sensitivity in response to abiotic stress in tomato is mediated by a new generation plant activator [PDF]

, 2013
Background: Yield losses as a result of abiotic stress factors present a significant challenge for the future of global food production. While breeding technologies provide potential to combat negative stress-mediated outcomes over time, interventions ...
Pickup, Doug, Douglas A Pickup, Nigel D Paul, Jason J Wargent, Paul, Nigel D., Roberts, Michael R., Michael R Roberts, Wargent, Jason J.   +7 more
core   +1 more source

Root tolerance to salinity stress: the role of chitosan-selenium nanoparticles on physiological and morphological responses of citrus seedlings roots

BMC Plant Biology
Backround Salinity stress severely limits citrus growth by impairing root development and physiological functions. Therefore, understanding of the mechanisms underlying root system architecture (RSA) adaptation in orange seedlings is crucial for ...
Azam Seyedi, Reza Saeedi, Sediqeh Afsharipour, Yogesh K. Ahlawat   +3 more
doaj   +1 more source

The effect of salinity on osmoregulation and development of the juvenile fat snook, Centropomus parallelus (POEY)

Brazilian Journal of Biology
Eurihaline fish support waters with different salt concentration. However, numerous studies have shown that salinity can affect fish development. Thus, the effect of salinity change from 20 to 5 and 35 on survival, weight, length, gill chloride cell ...
FC. Sterzelecki, E. Rodrigues, E. Fanta, CAO. Ribeiro   +3 more
doaj   +1 more source

Interactive effects of salinity and low potassium on growth, physiology response of Houttuynia cordata Thunb. W01-100 [PDF]

Journal of Stress Physiology & Biochemistry, 2012
Houttuynia cordata Thunb. is a plant enrichment in potassium in plant was reported. Salinity and low potassium availability are important environmental factors restricting plant growth and productivity throughout the world.
Zou Y. T., Dai S., Li J. Y., Liu Z. Q., Wu W.   +4 more
doaj