Results 191 to 200 of about 26,004 (264)

Molecular Glue Degraders Redefining Targeted Therapies From Discovery to Therapeutic Applications

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Molecular glue degraders (MGDs) constitute an emerging class of therapeutic agents poised to revolutionize the paradigm of targeted drug discovery. By reprogramming E3 ubiquitin ligases to degrade proteins of interest (POI) via a transient formation of a ternary complex mediated by protein–protein interactions, MGDs surpass the intrinsic limitations of
Jinfeng Wen, Jingtian Yu, Wuqiang Wen, Baishan Jiang   +3 more
wiley   +1 more source

Efficacy, safety, and predictive biomarkers of neoadjuvant nab-paclitaxel and pembrolizumab in hormone receptor-positive breast cancer: A randomized pilot trial. [PDF]

Nat Commun
Waks AG, Fu J, Chu X, Binboga Kurt B, Li T, Kuntz TM, Shen Y, Yang D, Meli K, Reardon B, Park J, Partridge A, Abravanel D, Jeselsohn R, Wrabel E, Alberti J, DiLullo M, Chen S, Mohammed-Abreu A, Sun X, Balko JM, Kleijn M, Audeh W, Morgan XC, Krop IE, Tayob N, Van Allen EM, Mittendorf EA, Tolaney SM.   +28 more
europepmc   +1 more source

Synthesis Strategies, Therapeutic Roles, and Clinical Progress of Gold Nanoparticles in Biomedical Engineering

Nano Select, Volume 7, Issue 3, March 2026.
Gold nanoparticles are revolutionizing medicine with their unique properties including optical, electrical, physical, and chemical features, as well as surface plasmon resonance. This versatility has positioned GNPs as a cornerstone in nanotechnology, especially within biomedical applications. Their facile synthesis and surface functionalization enable
Nastaran Mohseni, Danial Farahmand, Sara Ali Hosseinzadeh, Kokab Khosravipour, Vahideh Valizadeh   +4 more
wiley   +1 more source

NAB-paclitaxel and cisplatin versus gemcitabine and cisplatin as induction chemotherapy in locoregionally advanced nasopharyngeal carcinoma: a retrospective, propensity score-matched analysis. [PDF]

Ther Adv Med Oncol
Wang Q, Wang Z, Yang Q, Duan X, Peng L, You R, Liu Y, Xia T, Chen M, Huang P.   +9 more
europepmc   +1 more source

A Hybrid Nanosystem for Prostate Cancer Therapy: Codelivery of Enzalutamide and Curcumin via Selenium‐Embedded Mesoporous Silica and Chitosan Nanoparticles

ChemistryOpen, Volume 15, Issue 3, March 2026.
Herein, solvent extraction was selected for cetyltrimethylammonium bromide removal and the development of optimized Se‐embedded mesoporous silica nanoparticles, which were loaded with enzalutamide. Additionally, to improve the anticancer activity of Se@MSNPs‐Enz and curcumin bioavailability, curcumin‐loaded chitosan nanoparticles were prepared. This pH‐
Zahra Tavakoli, Khosro Khajeh, Bijan Ranjbar   +2 more
wiley   +1 more source

Early termination of NCT04617067, a phase II, open label, clinical trial of oral paricalcitol in combination with gemcitabine and NAB-paclitaxel therapy in advanced pancreatic cancer. [PDF]

BMC Cancer
Easty D, McDermott R, Murphy AG, Grogan L, Morris PG, Breathnach OS, Egan K, Toomey S, Horgan A, Power D, Osman N, Parker I, Donachie V, Shevlin A, Barrett A, Nolan M, Marron J, Farr CJ, Hennessy BT.   +18 more
europepmc   +1 more source

Safety and efficacy of salvage nano-particle albumin bound paclitaxel in recurrent cervical cancer: a feasibility study [PDF]

, 2016

core   +1 more source

A Reproducible Workflow for Macrophage Membrane Isolation and Nanocore Selection Toward Bioinspired Nanoparticles Targeting Immunologically Cold Tumors

Small Methods, Volume 10, Issue 5, 9 March 2026.
A reproducible workflow is established for isolating macrophage membranes to enable the efficient preparation and characterization of membrane‐coated nanoparticles. By optimizing M2‐like nanovesicle stability and nanocore compatibility, this procedure advances the engineering of macrophage membrane‐coated nanoparticles with improved tumor targeting ...
Diana Peixoto, Patricia Diaz‐Rodriguez, Francisco Veiga, Angel Concheiro, Ana Cláudia Paiva‐Santos, João Conde, Carmen Alvarez‐Lorenzo   +6 more
wiley   +1 more source

Real-world comparative effectiveness of FOLFIRINOX versus gemcitabine/nab-paclitaxel in metastatic pancreatic cancer: prognostic impact of metastatic site and burden in a Middle Eastern cohort. [PDF]

J Gastrointest Oncol
Eldehna WM, Elbarbry F, Shakra RA, Elrasad SA, Morsi ZA, Soaida SM, Wagdy WM, Aljohani AI, Abbas RM.   +8 more
europepmc   +1 more source

Multiscale Nanocellulosic Biomaterials in Therapeutics and Food Sciences

Small Structures, Volume 7, Issue 3, March 2026.
Multiscale nanocellulosic biomaterials offer exceptional physicochemical, mechanical, and biological properties; enabling transformative advances in therapeutics and food sciences. This review summarizes their structure–property relationships, key applications in drug delivery, tissue engineering, and food technology. Additionally, it outlines emerging
Hemant Singh, Blaise Tardy, Bruno Dufau Mattos, Shivi Tripathi, Mohd Hasan Mujahid, Sai Kumar Tammina, Narayan Chandra Mishra, Himanshu Sekhar Nanda, Fawzi Banat, Shabir Hassan   +9 more
wiley   +1 more source