Lactate dehydrogenase A: a potential new target for tumor drug resistance intervention. [PDF]
Wang M+6 more
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Can Sirtuin 1 Serve as a Therapeutic Target in Pulmonary Arterial Hypertension? A Comprehensive Review. [PDF]
Budziak S+3 more
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Nicotinamide mononucleotide protects ovarian function and oocyte developmental competence during chemotherapy. [PDF]
Shen L, Li H, Gong X, Zhang H, Zhao Y.
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The impacts of different dietary restriction regimens on aging and longevity: from yeast to humans. [PDF]
Ching TT, Hsu AL.
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PARP‑1 in liver diseases: Molecular mechanisms, therapeutic potential and emerging clinical applications (Review). [PDF]
Hu K+6 more
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Cellular senescence in renal ischemia-reperfusion injury. [PDF]
Chen Y, Yang L.
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(−)-Epigallocatechin Gallate is a Noncompetitive Inhibitor of NAD Kinase [PDF]
Nicotinamide adenine dinucleotide kinase (NADK) controls the intracellular NADPH content and provides reducing power for the synthesis of macromolecules and anti-ROS. Moreover, NADK is considered to be a synthetic lethal gene for KRAS mutations. To discover NADK-targeted probes, a high-throughput screening assay was established and optimized with a Z ...
Tonghai Liu+13 more
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NAD+ kinase catalyzes the only (known) biochemical reaction leading to the production of NADP+ from NAD+. Most evidence indicates it is found in the cytoplasm, but reports of its presence in (other) cell bodies can not be discounted. Viewed as a protein, our knowledge of NADK composition and architecture is rudimentary.
James R. Butler, Eugene T. McGuinness
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Protein kinase C activates NAD kinase in human neutrophils
Free Radical Biology and Medicine, 2020NAD kinase (NADK) is required for the de novo synthesis of NADP+ from NAD+. In neutrophils, NADK plays an essential role by providing sufficient levels of NADPH to support a robust oxidative burst. Activation of NADPH oxidase-2 (NOX-2) in neutrophils by stimulators of protein kinase C (PKC), such as phorbol myristate acetate (PMA), results in the rapid
François Graham+3 more
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