Results 101 to 110 of about 70,171 (129)

(−)-Epigallocatechin Gallate is a Noncompetitive Inhibitor of NAD Kinase [PDF]

open access: yesACS Medicinal Chemistry Letters, 2022
Nicotinamide adenine dinucleotide kinase (NADK) controls the intracellular NADPH content and provides reducing power for the synthesis of macromolecules and anti-ROS. Moreover, NADK is considered to be a synthetic lethal gene for KRAS mutations. To discover NADK-targeted probes, a high-throughput screening assay was established and optimized with a Z ...
Tonghai Liu   +13 more
openaire   +3 more sources

NAD+ kinase—A review

International Journal of Biochemistry, 1985
NAD+ kinase catalyzes the only (known) biochemical reaction leading to the production of NADP+ from NAD+. Most evidence indicates it is found in the cytoplasm, but reports of its presence in (other) cell bodies can not be discounted. Viewed as a protein, our knowledge of NADK composition and architecture is rudimentary.
James R. Butler, Eugene T. McGuinness
openaire   +3 more sources

Protein kinase C activates NAD kinase in human neutrophils

Free Radical Biology and Medicine, 2020
NAD kinase (NADK) is required for the de novo synthesis of NADP+ from NAD+. In neutrophils, NADK plays an essential role by providing sufficient levels of NADPH to support a robust oxidative burst. Activation of NADPH oxidase-2 (NOX-2) in neutrophils by stimulators of protein kinase C (PKC), such as phorbol myristate acetate (PMA), results in the rapid
François Graham   +3 more
openaire   +3 more sources

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