Nicotinamide Ameliorates Deoxynivalenol-Induced Injury in Renal Cells via Inhibiting PARP1 Hyperactivation and Restoring NAD+ Homeostasis [PDF]
ToxinsDeoxynivalenol (DON) is a globally prevalent mycotoxin that threatens food and feed safety via severe multi-organ toxicity. Previous studies indicate that DON induces cellular energy metabolism dysregulation by triggering oxidative stress and impairing ...
Chao Chen +5 more
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Biostimulants increase growth and yield of second-crop maize [PDF]
Revista Brasileira de Engenharia Agrícola e Ambiental, 2023 The use of biostimulants in second-crop maize (Zea mays) can promote higher physiological activity in plants, resulting in higher grain yield. This study aimed to evaluate the effects of phytohormones and nicotinamide on growth and yield traits of second-
Silvia E. N. Thomé +8 more
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L-carnitine administration effects on AMPK, APPL1 and PPARγ genes expression in the liver and serum adiponectin levels and HOMA-IR in type 2 diabetes rat model induced by STZ and nicotinamide [PDF]
The Ukrainian Biochemical Journal, 2020 Diabetes is a chronic disease and a public health problem globally. L-Carnitine is synthesized in the liver, promotes fatty acids oxidation and currently is used as a supplement against weight gain.
B. Shahouzehi +2 more
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Identification of Biological Functions and Prognostic Value of NNMT in Oral Squamous Cell Carcinoma
Biomolecules, 2022 Background: Nicotinamide N-methyltransferase (NNMT) is a metabolic enzyme that catalyzes the methylation of nicotinamide (NAM) to generate 1-methyl nicotinamide (MNAM).
Weixian Zhang +11 more
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Synthesis of Mixed Dinucleotides by Mechanochemistry
Molecules, 2022 We report the synthesis of vitamin B1, B2, and B3 derived nucleotides and dinucleotides generated either through mechanochemical or solution phase chemistry.
Faisal Hayat +3 more
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Toxins, 2023 Background: Panton–Valentine Leukocidin sustains a strong cytotoxic activity, targeting immune cells and, consequently, perforating the plasma membrane and inducing cell death.
Abdullah AlSaleh +3 more
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The Influence of Exercise Intensity on Tryptophan Metabolites in Thoroughbred Horses
Pharmaceuticals, 2023 Catabolism of tryptophan (Trp) is modulated by physical activity and provides a pool of active compounds: Trp is considered a calmative agent, kynurenine (Kyn) and 3-hydroxykynurenine (3-HKyn) show neurotoxic effects, kynurenic acid (Kyna) and ...
Magdalena Staniszewska +3 more
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Fate of Nicotinamide Differs Due to an Intake of Nicotinamide [PDF]
Bioscience, Biotechnology, and Biochemistry, 1996 We found that the catabolism of nicotinamide (Nam) differs due to an intake of Nam itself in rats. When rats were fed with a Nam-free, tryptophan-limiting diet, the major catabolite of niacin was N1-methyl-4-pyridone-3-carboxamide (4-Py). However, its percentage was changed with increasing the intake of Nam.
SHIBATA, Katsumi +2 more
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Antioxidants, 2021 Vitamin B3 (nicotinic acid, niacin) deficiency causes the systemic disease pellagra, which leads to dermatitis, diarrhea, dementia, and possibly death depending on its severity and duration.
Yong Chool Boo
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Antioxidant and anti-infl ammatory eff ects of nicotinamide adenine dinucleotide (nad+) against acute hepatorenal oxidative injury in an experimental sepsis model [PDF]
Kafkas Universitesi Veteriner Fakültesi Dergisi, 2022 The aim of this study is to determine the antioxidant and anti-infl ammatory eff ects of Nicotinamide Adenine Dinucleotide (NAD+) in preventing multi-organ damage caused by sepsis.
Songul DOGANAY +3 more
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