Results 1 to 10 of about 222,121 (295)

L-kynurenine or nicotinamide supplementations mitigate uterine decidualization impairments during early pregnancy of uninephrectomized mice [PDF]

Frontiers in Physiology
Impaired renal reserve induced by unilateral nephrectomy (UNx) leads to the full-spectrum of phenotypes of preeclampsia (PE) in mice. L-kynurenine (a product of L-tryptophan metabolism) supplementation throughout the entire pregnancy rescues the PE-like ...
Yuye Wang, Qing Ma, Meitong Chen, Yukako Kayashima, Nobuyo Maeda-Smithies, Feng Li   +5 more
doaj   +2 more sources

Mitochondrial Resilience in Glaucoma: Targeting NAD⁺ Metabolism and Oxidative Stress in Retinal Ganglion Cell Degeneration with Nicotinamide Riboside and Berberine: Preliminary Clinical Evidence [PDF]

Diseases
Background: Glaucoma is a chronic neurodegenerative disorder characterized by the selective vulnerability of retinal ganglion cells (RGCs), in which mitochondrial dysfunction, redox imbalance, and impaired bioenergetic signaling play central pathogenetic
Federico Visalli, Francesco Cappellani, Giuseppe Gagliano, Alfonso Spinello, Alessandro Avitabile, Ludovica Cannizzaro, Matteo Capobianco, Caterina Gagliano, Marco Zeppieri   +8 more
doaj   +2 more sources

Design, Synthesis, In Silico and In Vitro Studies of New Immunomodulatory Anticancer Nicotinamide Derivatives Targeting VEGFR-2

Molecules, 2022
VEGFR-2, the subtype receptor tyrosine kinase (RTK) responsible for angiogenesis, is expressed in various cancer cells. Thus, VEGFER-2 inhibition is an efficient approach for the discovery of new anticancer agents.
Reda G. Yousef, Wagdy M. Eldehna, Alaa Elwan, Abdelaziz S. Abdelaziz, Ahmed B. M. Mehany, Ibraheem M. M. Gobaara, Bshra A. Alsfouk, Eslam B. Elkaeed, Ahmed M. Metwaly, Ibrahim H. Eissa   +9 more
doaj   +1 more source

Nicotinamide Efficiently Suppresses Porcine Epidemic Diarrhea Virus and Porcine Deltacoronavirus Replication

Viruses, 2023
Porcine epidemic diarrhea virus (PEDV) and porcine deltacoronavirus (PDCoV), members of the genus Coronavirus, mainly cause acute diarrhea, vomiting and dehydration in piglets, and thus lead to serious economic losses.
Mingxia Li, Liping Zhang, Li Pan, Peng Zhou, Ruiming Yu, Zhongwang Zhang, Jianliang Lv, Huichen Guo, Yonglu Wang, Sa Xiao, Xinsheng Liu   +10 more
doaj   +1 more source

Nicotinamide Attenuates the Progression of Renal Failure in a Mouse Model of Adenine-Induced Chronic Kidney Disease

Toxins, 2021
Nicotinamide adenine dinucleotide (NAD+) supplies energy for deoxidation and anti-inflammatory reactions fostering the production of adenosine triphosphate (ATP).
Satoshi Kumakura, Emiko Sato, Akiyo Sekimoto, Yamato Hashizume, Shu Yamakage, Mariko Miyazaki, Sadayoshi Ito, Hideo Harigae, Nobuyuki Takahashi   +8 more
doaj   +1 more source

Insights into structural, spectroscopic, and hydrogen bonding interaction patterns of nicotinamide–oxalic acid (form I) salt by using experimental and theoretical approaches

Frontiers in Chemistry, 2023
In the present work, nicotinamide–oxalic acid (NIC-OXA, form I) salt was crystallized by slow evaporation of an aqueous solution. To understand the molecular structure and spectroscopic properties of NIC after co-crystallization with OXA, experimental ...
Priya Verma, Anubha Srivastava, Poonam Tandon, Manishkumar R. Shimpi   +3 more
doaj   +1 more source

Activation of Deoxyribonuclease I by Nicotinamide as a New Strategy to Attenuate Tetracycline-Resistant Biofilms of Cutibacterium acnes

Pharmaceutics, 2021
Biofilms of Cutibacterium (C.) acnes (formerly Propionibacterium acnes) are responsible for the persistence and antibiotic resistance of acne vulgaris. In addition to the standard treatments for acne vulgaris, a common adjunctive treatment is the topical
Yi-Hsien Shih, Donald Liu, Yen-Chou Chen, Ming-Hsuan Liao, Woan-Ruoh Lee, Shing-Chuan Shen   +5 more
doaj   +1 more source

Binding of caffeine with nicotinamide: A study by means of fluorescence quenching and UV-Vis spectroscopic techniques

St. Petersburg Polytechnical University Journal: Physics and Mathematics, 2023
In this work, the binding of caffeine (CAF) with nicotinamide (NIC) has been investigated by means of fluorescence quenching and UV-Vis spectroscopic techniques.
Gebreyohanes Ataklti Abraha, Gemta Abebe Belay   +1 more
doaj   +1 more source

Determination of Nine Kinds of Vitamin B Components in Healthy Food Vitamin B Tablets by HPLC

Shipin gongye ke-ji, 2022
Objective: To establish a method for the determination of nine vitamin B components in vitamin B tablets by high performance liquid chromatography-diode array detector (HPLC-DAD). Method: Folic acid was ultrasonically extracted with 0.3% ammonia solution,
Wanqing TAN, Shuling WANG, Riqing GUAN
doaj   +1 more source

Extension of use of nicotinamide riboside chloride as a novel food pursuant to Regulation (EU) 2015/2283

EFSA Journal, 2021
Following a request from the European Commission, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver an opinion on the safety of an extension of use of the novel food (NF) nicotinamide riboside chloride (NRC) pursuant ...
EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA), Dominique Turck, Torsten Bohn, Jacqueline Castenmiller, Stefaan De Henauw, Karen Ildico Hirsch‐Ernst, Alexandre Maciuk, Inge Mangelsdorf, Harry J McArdle, Androniki Naska, Carmen Pelaez, Kristina Pentieva, Alfonso Siani, Frank Thies, Sophia Tsabouri, Marco Vinceti, Francesco Cubadda, Thomas Frenzel, Marina Heinonen, Miguel Prieto Maradona, Rosangela Marchelli, Monika Neuhäuser‐Berthold, Morten Poulsen, Josef Rudolf Schlatter, Henk van Loveren, Océane Albert, Agnès de Sesmaisons Lecarré, Helle Katrine Knutsen   +27 more
doaj   +1 more source