Results 1 to 10 of about 42,137 (194)

Niacin ameliorates ulcerative colitis via prostaglandin D2‐mediated D prostanoid receptor 1 activation

EMBO Molecular Medicine, 2017
Niacin, as an antidyslipidemic drug, elicits a strong flushing response by release of prostaglandin (PG) D2. However, whether niacin is beneficial for inflammatory bowel disease (IBD) remains unclear. Here, we observed niacin administration‐enhanced PGD2
Lifu Wang, Richard M. Breyer, Huiyong Yin   +2 more
exaly   +2 more sources

Niacin exacerbates β cell lipotoxicity in diet-induced obesity mice through upregulation of GPR109A and PPARγ2: Inhibition by incretin drugs

Frontiers in Endocrinology, 2022
The widely used lipid-lowering drug niacin was reported to increase blood glucose in diabetes. How does niacin regulate β Cell function in diabetic patients remains unclear.
Xiaojing Zhang, Baoyi Zhu, Peibin Lin, Xiaoping Liu, Jun Gao, Dazhong Yin, Jianwen Zeng, Baojian Liao, Baojian Liao, Zhanfang Kang   +9 more
doaj   +1 more source

Niacin Status Indicators and Their Relationship with Metabolic Parameters in Dairy Cows during Early Lactation

Animals, 2022
Previous experimental models on cows have examined the difference in the metabolic adaptation in cows after niacin administration, without identifying the most important mediators between niacin administration and its biological effects, namely active ...
Kosta Petrović, Radojica Djoković, Marko Cincović, Talija Hristovska, Miroslav Lalović, Miloš Petrović, Mira Majkić, Maja Došenović Marinković, Ljiljana Anđušić, Gordana Devečerski, Dragica Stojanović, Filip Štrbac   +11 more
doaj   +1 more source

The interaction of dietary niacin and lipid affects the growth, antioxidant capacity and lipid metabolism of male Eriocheir sinensis

Aquaculture Reports, 2023
A 60-day feeding trial was conducted to determine the effects of the interaction of dietary niacin and lipid on the growth, antioxidant capacity and lipid metabolism in male Eriocheir sinensis.
Wenlong Wan, Jie Xu, Jiayuan Shi, Xin Zhang, Anran Wang, Xiaojing Dong, Shuyan Miao   +6 more
doaj   +1 more source

Niacin – a scoping review for Nordic Nutrition Recommendations 2023

Food & Nutrition Research, 2023
Niacin is the precursor to pyridine nucleotides NAD (nicotinamide adenine dinucleotide) and NADP (nicotinamide adenine dinucleotide phosphate). Niacin (vitamin B3) is the common term for nicotinic acid, nicotinamide and derivatives that exhibit the ...
Riitta Freese, Vegard Lysne
doaj   +1 more source

Dietary Niacin Supplementation Suppressed Hepatic Lipid Accumulation in Rabbits [PDF]

Asian-Australasian Journal of Animal Sciences, 2016
An experiment was conducted to investigate the effect of niacin supplementation on hepatic lipid metabolism in rabbits. Rex Rabbits (90 d, n = 32) were allocated to two equal treatment groups: Fed basal diet (control) or fed basal diet with additional ...
Lei Liu, Chunyan Li, Chunyan Fu, Fuchang Li   +3 more
doaj   +1 more source

Structural and Energetic Insights Into the Interaction of Niacin With the GPR109A Receptor

Bioinformatics and Biology Insights, 2021
The transmembrane G-protein coupled receptor GPR109A has been previously shown to function as a receptor for niacin in mediating antilipolytic effects.
Kiran Kumar Adepu, Sangita Kachhap, Andriy Anishkin, Sree V Chintapalli   +3 more
doaj   +1 more source

Niacin noncompetitively inhibits DGAT2 but not DGAT1 activity in HepG2 cells1

Journal of Lipid Research, 2004
Niacin is a widely used lipid-regulating agent in dyslipidemic patients. Previously, we have shown that niacin inhibits triacylglycerol synthesis.
Shobha H. Ganji, S. Tavintharan, Daming Zhu, Yiding Xing, Vaijinath S. Kamanna, Moti L. Kashyap   +5 more
doaj   +1 more source

Association between niacin and mortality among patients with cancer in the NHANES retrospective cohort

BMC Cancer, 2022
Background The vitamin niacin is used as a lipid-regulating supplement, but it is unknown whether niacin has a positive influence on cancer prognosis.
Hongan Ying, Lijie Gao, Nansheng Liao, Xijuan Xu, Wenfeng Yu, Weiwen Hong   +5 more
doaj   +1 more source

Low-Dose Niacin Supplementation Improves Motor Function in US Veterans with Parkinson’s Disease: A Single-Center, Randomized, Placebo-Controlled Trial

Biomedicines, 2021
A six-month double-blind, placebo-controlled randomized study was conducted to ascertain whether low-dose daily niacin supplementation would improve motor symptoms in Parkinson’s disease (PD) patients.
Chandramohan Wakade, Raymond Chong, Marissa Seamon, Sharad Purohit, Banabihari Giri, John C. Morgan   +5 more
doaj   +1 more source