Results 21 to 30 of about 33,672 (206)

Dietary Niacin Supplementation Suppressed Hepatic Lipid Accumulation in Rabbits [PDF]

Asian-Australasian Journal of Animal Sciences, 2016
An experiment was conducted to investigate the effect of niacin supplementation on hepatic lipid metabolism in rabbits. Rex Rabbits (90 d, n = 32) were allocated to two equal treatment groups: Fed basal diet (control) or fed basal diet with additional ...
Lei Liu, Chunyan Li, Chunyan Fu, Fuchang Li   +3 more
doaj   +1 more source

Nicotinamide riboside and pterostilbene reduces markers of hepatic inflammation in NAFLD: A double‐blind, placebo‐controlled clinical trial

Hepatology, EarlyView., 2022
NRPT 1X reduces ALT and ceramide 14:0 in 65% of subjects as compared to only 28% in the placebo group. Abstract Background and Aims The prevalence of NAFLD is increasing globally and on a path to becoming the most frequent cause of chronic liver disease. Strategies for the prevention and treatment of NAFLD are urgently needed.
Ryan W. Dellinger, Holly E. Holmes, Tina Hu‐Seliger, Rodney W. Butt, Stephen A. Harrison, Dariush Mozaffarian, Oliver Chen, Leonard Guarente   +7 more
wiley   +1 more source

Structural and Energetic Insights Into the Interaction of Niacin With the GPR109A Receptor

Bioinformatics and Biology Insights, 2021
The transmembrane G-protein coupled receptor GPR109A has been previously shown to function as a receptor for niacin in mediating antilipolytic effects.
Kiran Kumar Adepu, Sangita Kachhap, Andriy Anishkin, Sree V Chintapalli   +3 more
doaj   +1 more source

Niacin noncompetitively inhibits DGAT2 but not DGAT1 activity in HepG2 cells1

Journal of Lipid Research, 2004
Niacin is a widely used lipid-regulating agent in dyslipidemic patients. Previously, we have shown that niacin inhibits triacylglycerol synthesis.
Shobha H. Ganji, S. Tavintharan, Daming Zhu, Yiding Xing, Vaijinath S. Kamanna, Moti L. Kashyap   +5 more
doaj   +1 more source

Association between niacin and mortality among patients with cancer in the NHANES retrospective cohort

BMC Cancer, 2022
Background The vitamin niacin is used as a lipid-regulating supplement, but it is unknown whether niacin has a positive influence on cancer prognosis.
Hongan Ying, Lijie Gao, Nansheng Liao, Xijuan Xu, Wenfeng Yu, Weiwen Hong   +5 more
doaj   +1 more source

Low-Dose Niacin Supplementation Improves Motor Function in US Veterans with Parkinson’s Disease: A Single-Center, Randomized, Placebo-Controlled Trial

Biomedicines, 2021
A six-month double-blind, placebo-controlled randomized study was conducted to ascertain whether low-dose daily niacin supplementation would improve motor symptoms in Parkinson’s disease (PD) patients.
Chandramohan Wakade, Raymond Chong, Marissa Seamon, Sharad Purohit, Banabihari Giri, John C. Morgan   +5 more
doaj   +1 more source

EFFECT OF LOW-DOSE NIACIN ON DYSLIPIDEMIA, SERUM PHOSPHORUS LEVELS AND ADVERSE EFFECTS IN PATIENTS WITH CHRONIC KIDNEY DISEASE

Kidney Research and Clinical Practice, 2012
Niacin supplementation improves dyslipidemia and lowers serum phosphorus levels in chronic kidney disease (CKD) patients. However, its adverse effects, including hot flusing, hinder the administration of niacin.
Won Suk An, Hyo Jin Kang, Ki Hyun Kim
doaj   +1 more source

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

Scientific Opinion on Dietary Reference Values for niacin [PDF]

EFSA Journal, 2014
Following a request from the European Commission, the Panel on Dietetic Products, Nutrition and Allergies (NDA) derived Dietary Reference Values (DRVs) for niacin. Niacin is a generic term for nicotinic acid and nicotinamide. Niacin can be synthesised in
EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA)
doaj   +1 more source

Niacin increases HDL biogenesis by enhancing DR4-dependent transcription of ABCA1 and lipidation of apolipoprotein A-I in HepG2 cells

Journal of Lipid Research, 2012
The lipidation of apoA-I in liver greatly influences HDL biogenesis and plasma HDL levels by stabilizing the secreted apoA-I. Niacin is the most effective lipid-regulating agent clinically available to raise HDL.
Lin-Hua Zhang, Vaijinath S. Kamanna, Shobha H. Ganji, Xi-Ming Xiong, Moti L. Kashyap   +4 more
doaj   +1 more source