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Advances in Nutrition, 2016 Nicotinic acid and nicotinamide, collectively referred to as niacin, are nutritional precursors of the bioactive molecules nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP). NAD and NADP are important cofactors for most cellular redox reactions, and as such are essential to maintain cellular metabolism and ...
James B, Kirkland +1 more
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Effects of niacin restriction on sirtuin and PARP responses to photodamage in human skin. [PDF]
, 2012 Sirtuins (SIRTs) and poly(ADP-ribose) polymerases (PARPs), NAD(+)-dependent enzymes, link cellular energy status with responses to environmental stresses.
Benavente, Claudia A +2 more
core +9 more sources
BMC Cancer, 2022 Background The vitamin niacin is used as a lipid-regulating supplement, but it is unknown whether niacin has a positive influence on cancer prognosis.
Hongan Ying +5 more
doaj +1 more source
Low and deficient niacin status and pellagra are endemic in postwar Angola [PDF]
, 2007 BACKGROUND: Outbreaks of pellagra were documented during the civil war in Angola, but no contemporary data on the incidence of pellagra or the prevalence of niacin deficiency were available.
Cheung, E +6 more
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Whole blood NAD and NADP concentrations are not depressed in subjects with clinical pellagra [PDF]
, 2007 Population surveys for niacin deficiency are normally based on clinical signs or on biochemical measurements of urinary niacin metabolites. Status may also be determined by measurement of whole blood NAD and NADP concentrations. To compare these methods,
Cheung, E +5 more
core +2 more sources
Influence of dietary niacin on starter pig performance [PDF]
, 2001 Two experiments were conducted using 415 weanling pigs (175 in Exp. 1, 240 in Exp. 2) to determine the influence of dietary niacin inclusion on starter pig performance. Pigs were fed a control diet with no added niacin or the control diet with 25, 50,
Alonso, E. +7 more
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Niacin noncompetitively inhibits DGAT2 but not DGAT1 activity in HepG2 cells1
Journal of Lipid Research, 2004 Niacin is a widely used lipid-regulating agent in dyslipidemic patients. Previously, we have shown that niacin inhibits triacylglycerol synthesis.
Shobha H. Ganji +5 more
doaj +1 more source
Structural and Energetic Insights Into the Interaction of Niacin With the GPR109A Receptor
Bioinformatics and Biology Insights, 2021 The transmembrane G-protein coupled receptor GPR109A has been previously shown to function as a receptor for niacin in mediating antilipolytic effects.
Kiran Kumar Adepu +3 more
doaj +1 more source
Niacin-induced clotting factor synthesis deficiency with coagulopathy [PDF]
, 1992 Although coagulopathy is a well-known complication of severe niacin- induced hepatotoxic reaction, it is not found in patients with minimal aminotransferase level elevations.
Dearing, Brian D. +3 more
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Hepatology, EarlyView., 2022 NRPT 1X reduces ALT and ceramide 14:0 in 65% of subjects as compared to only 28% in the placebo group. Abstract Background and Aims The prevalence of NAFLD is increasing globally and on a path to becoming the most frequent cause of chronic liver disease. Strategies for the prevention and treatment of NAFLD are urgently needed.
Ryan W. Dellinger +7 more
wiley +1 more source