Results 41 to 50 of about 222,121 (295)

Metallochaperones Are Needed for Mycobacterium tuberculosis and Escherichia coli Nicotinamidase-Pyrazinamidase Activity. [PDF]

, 2020
Mycobacterium tuberculosis nicotinamidase-pyrazinamidase (PZAse) is a metalloenzyme that catalyzes conversion of nicotinamide-pyrazinamide to nicotinic acid-pyrazinoic acid. This study investigated whether a metallochaperone is required for optimal PZAse
Antiparra, R, Arteaga, H, Bueno, C, Campos, J, Duran, P, Gilman, RH, Huerta, R, Kirwan, DE, Monsalve, A, Sheen, P, Zimic, M   +10 more
core   +1 more source

An NAD+-dependent novel transcription factor controls stage conversion in Entamoeba

eLife, 2018
Developmental switching between life-cycle stages is a common feature among parasitic pathogens to facilitate disease transmission and pathogenesis.
Dipak Manna, Christian Stephan Lentz, Gretchen Marie Ehrenkaufer, Susmitha Suresh, Amrita Bhat, Upinder Singh   +5 more
doaj   +1 more source

Is there an interplay between adherence to mediterranean diet, antioxidant status, and vascular disease in atrial fibrillation patients? [PDF]

, 2016
Mediterranean Diet (Med-Diet) is associated with reduced incidence of vascular events (VEs) in atrial fibrillation (AF), but the mechanism accounting for its beneficial effect is only partially known.
Cristina Nocella, Daniele Pastori, Danilo Menichelli, Francesco Violi, Isabella Leo, Marta Novo, Pasquale Pignatelli, Roberto Carnevale, Simona Bartimoccia   +8 more
core   +1 more source

Nicotinamide Supplementation Improves Oocyte Quality and Offspring Development by Modulating Mitochondrial Function in an Aged Caenorhabditis elegans Model

Antioxidants, 2021
Aging is associated with a decline in the quality of biological functions. Among the aging processes, reproductive aging is a critical process because of its intergenerational effects.
Hyemin Min, Mijin Lee, Kyoung Sang Cho, Hyunjung Jade Lim, Yhong-Hee Shim   +4 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Nicotinamide Inhibits CD4+ T-Cell Activation and Function

Cells
Chronic inflammation and autoimmune diseases are driven, in part, by the activation of (auto)reactive CD4+ T-cells, highlighting their potential as therapeutic targets for these diseases.
Lotte Nijhuis, Alejandra Bodelόn, Rianne C. Scholman, Isabelle Houtzager, Lyanne J. P. M. Sijbers, Enric Mocholi, Lucas W. Picavet, Jorg J. A. Calis, Michal Mokry, Sebastiaan J. Vastert, Jorg van Loosdregt   +10 more
doaj   +1 more source

NADomics: Measuring NAD⁺ and Related Metabolites Using Liquid Chromatography Mass Spectrometry

Life, 2021
Nicotinamide adenine dinucleotide (NAD+) and its metabolome (NADome) play important roles in preserving cellular homeostasis. Altered levels of the NADome may represent a likely indicator of poor metabolic function.
Nady Braidy, Maria D. Villalva, Ross Grant   +2 more
doaj   +1 more source

Crystal Structure of Thermotoga maritima α-Glucosidase AglA Defines a New Clan of NAD+-dependent Glycosidases [PDF]

, 2003
Glycoside hydrolase family 4 represents an unusual group of glucosidases with a requirement for NAD(+), divalent metal cations, and reducing conditions. The family is also unique in its inclusion of both alpha- and beta-specific enzymes.
Hoffmann, Volker, Liebl, Wolfgang, Lodge, Jacinta A., Maier, Timm, Sträter, Norbert   +4 more
core   +2 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Tissue-specific effects of bacterial PncA overexpression on NAD+ metabolism and aging in mice: implications for tissue-specific aging interventions

Frontiers in Aging
BackgroundAs a critical molecule in biological systems, nicotinamide adenine dinucleotide (NAD+) influences the aging of mammals. Therefore, regulation of NAD+ synthesis and degradation may slow aging and mitigate related diseases.ResultsThis study ...
Fengjiao Huo, Meili Zhao, Yue Liu, Shuyao Lv, Shengyu Feng, Liuling Guo, Nan Wang, Shuaishuai Zhang, Qing Liu, Taotao Mi, Hao Wang, Jian-Kang Zhu, Hailiang Liu, Hailiang Liu, Hailiang Liu   +14 more
doaj   +1 more source