Results 41 to 50 of about 155,595 (297)
5-Trifluoromethoxy-substituted Nicotinic Acid, Nicotinamide and Related Compounds
Журнал органічної та фармацевтичної хіміїA practical and convenient method for synthesizing nicotinic acid and nicotinamide with the trifluoromethoxy group in position 5 of the ring has been developed.
Taras M. Sokolenko, Yurii L. Yagupolskii
doaj +1 more source
Nicotinamide prevention in diabetes-induced alterations in the rat liver
Endocrine Regulations, 2023 Objective. The study was performed to elucidate whether nicotinamide (NAm) can attenuate the diabetes-induced liver damage by correction of ammonia detoxifying function and disbalance of NAD-dependent processes in diabetic rats.
Kuchmerovska Tamara +5 more
doaj +1 more source
Toxins, 2016 N-methyl-2-pyridone-5-carboxamide (2PY, a major metabolite of nicotinamide, NAM) was recently identified as a uremic toxin. Recent interventional trials using NAM to treat high levels of phosphorus in end-stage renal disease have highlighted new ...
Aurélie Lenglet +10 more
doaj +1 more source
Synthesis of phosphodiester-type nicotinamide adenine dinucleotide analogs
, 2009 Fourteen phosphodiester-type beta-nicotinamide adenine dinucleotide (NAD+) analogs were prepared starting from nicotinamide. The phosphodiester linkage was effectively assembled in 69-93% yields via condensation reaction between 2'.3'-di-O-acetyl ...
Wu, Siguo +4 more
core +1 more source
Biosynthesis of squalene and cholesterol by cell-free extracts of adult rat brain
Journal of Lipid Research, 1969 Cell-free extracts of adult rat brain incubated with mevalonic acid-2-14C synthesize 14C-labeled nonsaponifiable fractions consisting largely of squalene-14C.
M.T. Kelley +3 more
doaj +1 more source
Nanomaterials, 2022 Chitin nanofibrils (CN) and nanolignin (NL) were used to embed active molecules, such as vitamin E, sodium ascorbyl phosphate, lutein, nicotinamide and glycyrrhetinic acid (derived from licorice), in the design of antimicrobial, anti-inflammatory and ...
Maria-Beatrice Coltelli +8 more
doaj +1 more source
Nicotinamide-Containing Di- and Trinucleotides as Chemical Tools for Studies of NAD-Capped RNAs
, 2018 We report the chemical synthesis of a set of nicotinamide adenine dinucleotide (NAD) cap analogues containing chemical modifications that reduce their susceptibility to NAD-RNA-degrading enzymes.
Megerditch Kiledjian (2407492) +15 more
core +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Antioxidants, 2021 Aging is associated with a decline in the quality of biological functions. Among the aging processes, reproductive aging is a critical process because of its intergenerational effects.
Hyemin Min +4 more
doaj +1 more source
‘Guide and Prejudice’— How Argonautes recognize targets across domains of life
FEBS Letters, EarlyView.Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley +1 more source