Nicotinamide N-Methyltransferase and Liver Diseases [PDF]
Genes and Diseases, 2023 Cellular metabolism-induced epigenetic regulation is essential for the maintenance of cellular homeostasis. Nicotinamide N-methyltransferase (NNMT) is emerging as a key point of intersection between cellular metabolism and epigenetic regulation and has a
Guangyu Liang, Jiankun Yang, Shaobo Hu
exaly +7 more sources
Antisense oligonucleotide targeting nicotinamide N-methyltransferase exhibits antitumor effects [PDF]
Molecular Therapy: Nucleic AcidsNicotinamide N-methyltransferase (NNMT) is one of the methyltransferase family genes. It consumes S-adenosyl-l-methionine (SAM), which is required for DNA methylation and histone methylation for epigenetic regulation, to produce 1-methylnicotinamide from
Tomoaki Hara +13 more
doaj +7 more sources
Nicotinamide N-Methyltransferase in Head and Neck Tumors: A Comprehensive Review [PDF]
Biomolecules, 2021 The head and neck tumors (HNT) are a heterogeneous group of diseases ranging from benign to malignant lesions, with distinctive molecular and clinical behaviors. Several studies have highlighted the presence of an altered metabolic phenotype in HNT, such
Annamaria Offidani +2 more
exaly +7 more sources
Nicotinamide N-Methyltransferase: At the Crossroads Between Cellular Metabolism and Epigenetic Regulation [PDF]
Molecular Metabolism, 2021 Background: The abundance of energy metabolites is intimately interconnected with the activity of chromatin-modifying enzymes in order to guarantee the finely tuned modulation of gene expression in response to cellular energetic status.
Annalisa Roberti, Mario F Fraga
exaly +8 more sources
Complex roles of nicotinamide N-methyltransferase in cancer progression [PDF]
Cell Death and Disease, 2022 Nicotinamide N-methyltransferase (NNMT) is an intracellular methyltransferase, catalyzing the N-methylation of nicotinamide (NAM) to form 1-methylnicotinamide (1-MNAM), in which S-adenosyl-l-methionine (SAM) is the methyl donor.
Weixuan Wang +3 more
doaj +4 more sources
Nicotinamide N-Methyltransferase (NNMT): A Novel Therapeutic Target for Metabolic Syndrome [PDF]
Frontiers in PharmacologyMetabolic syndrome (MetS) represents a constellation of metabolic abnormalities, typified by obesity, hypertension, hyperglycemia, and hyperlipidemia. It stems from intricate dysregulations in metabolic pathways governing energy and substrate metabolism.
Jiang-Hua Li, Wei-Dong Sun, Ya-Zhong Mei
exaly +4 more sources
Systematic pan-cancer analysis of the nicotinamide n-methyltransferase in human cancer [PDF]
Frontiers in Genetics, 2022 In several tumors, Nicotinamide N-Methyltransferase (NNMT) was identified as a bridge between methylation metabolism and tumorigenesis and was associated with a poor prognosis.
Li Cao +9 more
doaj +2 more sources
Nicotinamide N‐methyltransferase is related to MELF pattern invasion in endometrioid carcinoma [PDF]
Cancer Medicine, 2021 Grade 1 (G1) endometrioid carcinoma (EC) is relatively a good prognosis. However, in a minority of cases, G1 shows an aggressive histological pattern known as the microcystic, elongated, and fragmented (MELF) pattern.
Shinichiro Tahara +8 more
doaj +2 more sources
Nicotinamide N‐methyltransferase inhibition improves limb function in experimental peripheral artery disease [PDF]
Physiological ReportsPeripheral artery disease (PAD) impairs limb perfusion, walking ability, and increases the risk of amputation. Although current therapies reduce cardiovascular events, few interventions improve skeletal muscle function in PAD.
Gengfu Dong +6 more
doaj +2 more sources
Nicotinamide N-Methyltransferase: A Promising Biomarker and Target for Human Cancer Therapy [PDF]
Frontiers in Oncology, 2022 Cancer cells typically exhibit a tightly regulated program of metabolic plasticity and epigenetic remodeling to meet the demand of uncontrolled cell proliferation.
Xiao-Yu Li +4 more
doaj +2 more sources