High-Affinity Alkynyl Bisubstrate Inhibitors of Nicotinamide N‑Methyltransferase (NNMT)
, 2019 Nicotinamide N-methyltransferase (NNMT) is a metabolic enzyme that methylates nicotinamide (NAM) using cofactor S-adenosylmethionine (SAM). NNMT overexpression has been linked to diabetes, obesity, and various cancers.
Aimo Kannt (597070) +14 more
core +8 more sources
Nicotinamide N-Methyltransferase in the Inflammatory Pathogenesis of Graves' Orbitopathy. [PDF]
Invest Ophthalmol Vis SciNicotinamide N-methyltransferase (NNMT) has been implicated in inflammatory autoimmune disease pathogenesis, although its pro-inflammatory role in Graves' orbitopathy (GO) is unclear. Therefore, we investigated the influence and mechanisms of NNMT in GO inflammation.We evaluated NNMT mRNA expression in GO and non-GO orbital tissues via reverse ...
Cho D, Choi SH, Yoon JS, Ko J.
europepmc +3 more sources
Roles of Nicotinamide N-Methyltransferase in Obesity and Type 2 Diabetes. [PDF]
Biomed Res Int, 2021 Type 2 diabetes (T2D) is thought to be a complication of metabolic syndrome caused by disorders of energy utilization and storage and characterized by insulin resistance or deficiency of insulin secretion. Though the mechanism linking obesity to the development of T2D is complex and unintelligible, it is known that abnormal lipid metabolism and adipose
Liu JR +5 more
europepmc +4 more sources
Nicotinamide N-Methyltransferase in Acquisition of Stem Cell Properties and Therapy Resistance in Cancer [PDF]
International Journal of Molecular Sciences, 2021 Koraljka Gall Trošelj +2 more
exaly +2 more sources
A Case Study of Dysfunctional Nicotinamide Metabolism in a 20-Year-Old Male
Metabolites, 2023 We present a case study of a 20-year-old male with an unknown neurodegenerative disease who was referred to the Undiagnosed Diseases Network Vanderbilt Medical Center site.
Karen L. DeBalsi +9 more
doaj +1 more source
Tetrahydroisoquinoline-Triazole Derivatives: Novel Nicotinamide N-Methyltransferase Inhibitors
AppliedChem, 2023 Through the Lilly Open Innovation Drug Discovery program (OIDD), we discovered five cationic bis(aryltriazol-4-yl)methyl)-6,7-dimethoxytetrahydroisoquinolinium derivatives that effectively inhibit human nicotinamide N-methyltransferase. Compounds 4a, 4c,
Alison T. Ung, Matthew Payne
doaj +1 more source
Open Medicine, 2022 Previous studies indicated that dysregulated expression of nicotinamide N-methyltransferase (NNMT) contributed to the tumor progression and predicted poor prognosis in various cancers.
Dang Ling, Wang Yingdong
doaj +1 more source
Macrocyclic peptides as allosteric inhibitors of nicotinamide N-methyltransferase (NNMT) [PDF]
, 2021 Nicotinamide N-methyltransferase (NNMT) methylates nicotinamide to form 1-methylnicotinamide (MNA) using S-adenosyl-l-methionine (SAM) as the methyl donor.
Thijssen V +13 more
core +3 more sources
Macrocyclic Peptides as Allosteric Inhibitors of Nicotinamide N-Methyltransferase (NNMT) [PDF]
, 2020 Nicotinamide N-methyltransferase (NNMT) methylates nicotinamide to form 1-methylnicotinamide using S-adenosyl-l-methionine (SAM) as the methyl donor. The complexity of the role of NNMT in healthy and disease states is slowly being elucidated and provides
Nathaniel, Martin +7 more
core +2 more sources
Hepatoblastomas exhibit marked downregulation driven by promoter DNA hypermethylation
Tumor Biology, 2020 Hepatoblastomas exhibit the lowest mutational burden among pediatric tumors. We previously showed that epigenetic disruption is crucial for hepatoblastoma carcinogenesis.
Maria Prates Rivas +22 more
doaj +1 more source