Results 41 to 50 of about 13,531,604 (176)

Bisubstrate inhibitors of nicotinamide N-methyltransferase (NNMT) with enhanced activity [PDF]

, 2019
Nicotinamide N-methyltransferase (NNMT) catalyzes the methylation of nicotinamide to form N-methylnicotinamide. Overexpression of NNMT is associated with a variety of diseases, including a number of cancers and metabolic disorders, suggesting a role for ...
Gao, Yongzhi, Jin, Jian, Salvucci, Alessia, Babault, Nicolas, Haren, M.J. van, Martin, N.I., Craveur, Pierrick, Martin, Nathaniel I., Salvucci, A., Sartini, D., Emanuelli, M., Moret, Ed E., Gao, Y., Craveur, P., Emanuelli, Monica, Moret, E.E., Babault, N., Rood, Johannes J.M., Jin, J., Van Haren, Matthijs J., Sartini, Davide, Rood, J.J.M., Afd Chemical Biology and Drug Discovery, Chemical Biology and Drug Discovery, Babault N, Afd Pharmacoepi & Clinical Pharmacology, Pharmacoepidemiology and Clinical Pharmacology, Moret EE, Jin J, Craveur P, Sartini D, Rood JJM, Gao Y, van Haren MJ, Martin NI, Emanuelli M   +35 more
core   +3 more sources

Identification of nicotinamide N-methyltransferase as a promising therapeutic target for sarcopenia. [PDF]

Aging Cell
AbstractSarcopenia is a significant geriatric syndrome that involves the loss of skeletal muscle mass and strength. Due to its substantial endocrine role, the metabolic microenvironment of skeletal muscle undergoes changes with age. Examining the pathogenesis of sarcopenia through focusing on metabolic dysregulation could offer insights for developing ...
Liang R, Xiang Q, Dai M, Lin T, Xie D, Song Q, Liu Y, Yue J.   +7 more
europepmc   +3 more sources

Potent Inhibition of Nicotinamide N-Methyltransferase by Alkene-Linked Bisubstrate Mimics Bearing Electron Deficient Aromatics [PDF]

, 2021
Nicotinamide N-methyltransferase (NNMT) methylates nicotinamide (vitamin B3) to generate 1-methylnicotinamide (MNA). NNMT overexpression has been linked to a variety of diseases, most prominently human cancers, indicating its potential as a therapeutic ...
Gutiérrez-de-Terán H, Campagna R, Jespers W, Sartini D, Parsons RB, van Westen GJP, Buijs N, Zhang Y, Gao Y, van Haren MJ, Martin NI, Innocenti P, Emanuelli M   +12 more
core   +3 more sources

Serum N1‐Methylnicotinamide is Associated With Coronary Artery Disease in Chinese Patients

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundWe previously reported that serum N1‐methylnicotinamide (me‐Nam), an indicator of nicotinamide N‐methyltransferase activity, is associated with obesity and diabetes mellitus in Chinese patients. However, whether nicotinamide N‐methyltransferase
Ming Liu, Jihong Chu, Yang Gu, Haibo Shi, Rusheng Zhang, Lingzhun Wang, Jiandong Chen, Le Shen, Peng Yu, Xiaohu Chen, Wenzheng Ju, Zhenxing Wang   +11 more
doaj   +1 more source

Nicotinamide N-methyltransferase expression in squamous cell carcinoma of the vulva

Journal of Obstetrics and Gynaecology, 2022
The molecular pathways involved in the development of vulvar squamous cell carcinoma (SCC) cancer are not completely known. Nicotinamide N-methyltransferase (NNMT) is a cytosolic enzyme associated with tumorigenesis and metastasis in a variety of cancers. Its role in vulvar cancer has not been studied, previously.
Zeliha Esin Çelik, Serra Akar, Sıddıka Fındık, Emine Aytekin, Çetin Çelik   +4 more
openaire   +2 more sources

High-Affinity Alkynyl Bisubstrate Inhibitors of Nicotinamide N-Methyltransferase (NNMT) [PDF]

, 2019
Nicotinamide N-methyltransferase (NNMT) is a metabolic enzyme responsible for the methylation of nicotinamide (NAM) using cofactor S-adenosylmethionine (SAM). NNMT overexpression has been linked to diabetes, obesity, and a variety of cancers.
Policarpo, Rocco Louis
core   +7 more sources

High stromal nicotinamide N‐methyltransferase (NNMT) indicates poor prognosis in colorectal cancer

Cancer Medicine, 2020
Purpose Nicotinamide n‐methyltransferase (NNMT) has good biochemical activity and epigenetic regulation, and has been reported as a major metabolic regulator of cancer. The goal of this study was to investigate the significance of stromal NNMT expression
Mengmeng Song, Ye Li, Mingyong Miao, Fan Zhang, Hao Yuan, Fuao Cao, Wenjun Chang, Hanping Shi, Chunhua Song   +8 more
doaj   +1 more source

Nicotinamide N-Methyltransferase: An Emerging Protagonist in Cancer Macro(r)evolution

Biomolecules, 2021
Nicotinamide N-methyltransferase (NNMT) has progressed from being considered merely a Phase II metabolic enzyme to one with a central role in cell function and energy metabolism. Over the last three decades, a significant body of evidence has accumulated
Richard B. Parsons, Paul D. Facey
doaj   +1 more source

Correlation of NNMT and DKK1 Protein Expression With Clinicopathological Characteristics and Prognosis of Breast Cancer

Clinical Medicine Insights: Oncology, 2023
Background: Nicotinamide N-methyltransferase (NNMT) and Dickkopf-1 (DKK1) play an important role in the development of breast cancer, and the purpose of this study was designed to examine the clinical and prognostic significance of NNMT and DKK1 in ...
Tairong Liang, Xiuqian Wu, Lan Wang, Tiantian Song, Peishan Wu, Yongdong Niu, Haihua Huang   +6 more
doaj   +1 more source

Lipopolysaccharide affects energy metabolism and elevates nicotinamide N-methyltransferase level in human aortic endothelial cells (HAEC) [PDF]

, 2022
This study aimed to investigate the putative role of nicotinamide N-methyltransferase in the metabolic response of human aortic endothelial cells. This enzyme catalyses S-adenosylmethionine-mediated methylation of nicotinamide to methylnicotinamide. This
Dymkowska, Dorota, Mateuszuk, Łukasz, Zabłocki, Krzysztof, Stępińska, Oksana   +3 more
core   +1 more source