Results 61 to 70 of about 13,531,604 (176)

Illuminating point‐of‐care diagnostics with aggregation‐induced emission biosensors

FlexMat, EarlyView.
This review highlights the application of aggregation‐induced emission luminogens (AIEgens) in point‐of‐care (POC) diagnostics for disease biomarker detection. It systematically examines a range of biosensing platforms, including lateral flow immunoassays, microfluidic chips, and electrochemiluminescence sensors, alongside their utility in detecting ...
Danni Hu, Yubing Hu, Dong Wang, Ben Zhong Tang   +3 more
wiley   +1 more source

Nicotinamide N-methyltransferase enhances chemoresistance in breast cancer through SIRT1 protein stabilization

Breast Cancer Research, 2019
Background Nicotinamide N-methyltransferase (NNMT) is overexpressed in various human tumors and involved in the development and progression of several carcinomas. In breast cancer, NNMT was found to be overexpressed in several cell lines.
Yanzhong Wang, Jin Zeng, Weiping Wu, Shuduo Xie, Haitao Yu, Guoli Li, Tao Zhu, Fengying Li, Jie Lu, Gavin Y. Wang, Xinyou Xie, Jun Zhang   +11 more
doaj   +1 more source

Epigenetic Regulation in the Pathogenesis of Renal Inflammation: Insights and Therapeutic Potentials

iNew Medicine, EarlyView.
ABSTRACT Renal inflammation is a common pathological process in various kidney diseases, often initiated by factors such as toxins, ischemia, or autoimmune reactions. This inflammatory response can result in structural damage and a rapid decline in renal function.
Yu‐Hang Dong, Xiao‐Yu Shen, Han‐Cheng Jin, Xiang‐Yu Li, Hao He, Xiao‐Ming Meng   +5 more
wiley   +1 more source

Supplementary Table 1 from Identification of Nicotinamide N-Methyltransferase as a Novel Serum Tumor Marker for Colorectal Cancer

, 2005
Supplementary Table 1 from Identification of Nicotinamide N-Methyltransferase as a Novel Serum Tumor Marker for Colorectal ...
Wolfgang Rösch (14978610), Michael Pfeffer (14978595), Werner Zolg (14978613), Wolfgang Rollinger (14978583), Michael Tacke (14978616), Siegbert Rossol (3144807), Heinz Bodenmüller (14978601), Gerhard Rohr (14978607), Thomas Henkel (2505535), Alfred M. Engel (14978589), Johann Karl (9656250), Stefan Palme (1936996), Peter Berndt (183205), Hanno Langen (27040), Herbert Andres (14978598), Josef Rüschoff (14978604), Markus Roeßler (14978580), Marie-Luise Hagmann (14978586), Bernd Schneidinger (14978592)   +18 more
core   +1 more source

ATP Citrate Lyase in Metabolic Disease: Mechanistic Insights and Clinical Potential

iNew Medicine, EarlyView.
ATP citrate lyase (ACLY) is a central metabolic hub that diverts mitochondrial citrate to fuel de novo lipogenesis, cholesterol biosynthesis, and protein acetylation. Given its robust correlation with pathological changes in multiple human diseases, ACLY inhibitors featuring distinct pharmacological strengths have been developed for therapeutic ...
Wenbiao Wang, Xinyan Li, Honglu Shi, Gaolei Song, Zhifu Xie, Jingya Li   +5 more
wiley   +1 more source

Patients with low nicotinamide N-methyltransferase expression benefit significantly from bevacizumab treatment in ovarian cancer

BMC Cancer, 2021
Background The role of nicotinamide N-methyltransferase (NNMT) in ovarian cancer is still elusive. Our aim is to explore the expression of NNMT in ovarian cancer and to assess its association with patient prognosis and treatment response.
Jun Li, Huiran Yue, Hailin Yu, Xin Lu, Xiaohong Xue   +4 more
doaj   +1 more source

Data‐Independent Acquisition Mass Spectrometry in Tumor Classification and Cancer Biomarker Research

Mass Spectrometry Reviews, EarlyView.
Abstract Cancer treatment is far from optimal also because current classification systems do not reflect the complex molecular status of the tumor and its phenotype in sufficient detail. To construct molecular tumor classifiers, omics tools provide complex molecular data reflecting many aspects from genotype to phenotype.
Jan Simonik, Petr Lapcik, Pavla Bouchalova, Pavel Bouchal   +3 more
wiley   +1 more source

Inhibitors of nicotinamide N-methyltransferase designed to mimic the methylation reaction transition state [PDF]

, 2017
Nicotinamide N-methyltransferase (NNMT) is an enzyme that catalyses the methylation of nicotinamide to form N'-methylnicotinamide. Both NNMT and its methylated product have recently been linked to a variety of diseases, suggesting a role for the enzyme ...
Afd Chemical Biology and Drug Discovery, Parsons, Richard B., van Haren, Matthijs J, Martin, Nathaniel I, Monica Emanuelli, Chemical Biology and Drug Discovery, Martin, Nathaniel I., Moret, Ed E, Moret, Ed E., Rebecca Taig, Parsons, Richard B, Jilles Kuppens, Taig, Rebecca, Kuppens, Jilles, Richard B. Parsons, Sastre Toraño, Javier, Matthijs J. van Haren, Emanuelli, Monica, Javier Sastre Toraño, Ed E. Moret, Davide Sartini, Nathaniel I. Martin, Sartini, Davide, Van Haren, Matthijs J., Kuppens, J., Taig R, Moret, E.E., Moret EE, Kuppens J, Haren, M.J. van, Martin, N.I., Sartini, D., Emanuelli, M., Sartini D, Parsons RB, Taig, R., Parsons, R.B., Sastre Toraño J, van Haren MJ, Martin NI, Sastre Toraño, J., Emanuelli M   +41 more
core   +1 more source

Chronic high‐altitude exposure and intracerebral hemorrhage: A novel perspective from the vascular‐immune‐neuronal network

Neuroprotection, EarlyView.
Long‐term chronic high‐altitude hypobaric hypoxia increases susceptibility to ICH, particularly among migrant populations lacking EPAS1/SENP1 adaptive genetic variants relative to high‐altitude indigenous residents. Persistent hypoxia initiates blood–brain barrier (BBB) breakdown, aberrant glial and immune activation, and progressive neuronal injury ...
Rongsu Huang, Linjie Wei, Mingxi Li, Bo Wu, Rongjian Ouyang, Gang Zhu, Yujie Chen   +6 more
wiley   +1 more source

Citrullination Inactivates Nicotinamide‑N‑methyltransferase

, 2018
Nicotinamide-N-methyl­transferase (NNMT) catalyzes the irreversible methylation of nicotinamide (NAM) to form N-methyl nicotinamide using S-adenosyl methionine as a methyl donor. NNMT is implicated in several chronic disease conditions, including cancers,
Eranthie Weerapana (1377093), Ronak Tilvawala (1453684), Son Hong Nguyen, Lacey Miller, Ari J. Salinger, Son Hong Nguyen (1958257), Eranthie Weerapana, Venkatesh V. Nemmara (1969867), Venkatesh V. Nemmara, Ronak Tilvawala, Paul R. Thompson (105487), Lacey Miller (5614409), Paul R. Thompson, Ari J. Salinger (2910698)   +13 more
core   +1 more source