Results 1 to 10 of about 2,900 (147)

NNMT and the methylation sink: integrating metabolism, epigenetics and immunity in cancer [PDF]

BMC Medicine
Nicotinamide N-methyltransferase (NNMT) is a methyltransferase that uses S-adenosyl-L-methionine (SAM, cofactor) to catalyze the N-methylation of nicotinamide (NAM, substrate), yielding 1-methylnicotinamide (MNAM) and S-adenosyl-homocysteine (SAH).
Lvyuan Li, Yichun Ma, Yani Pan, Bowen Li, Chen Chen, Qiang Wang, Yao Fu, Xiangshan Fan, Shouyu Wang, Zhangding Wang   +9 more
doaj   +3 more sources

High Stromal Nicotinamide N-Methyltransferase (NNMT) Indicates Poor Prognosis in Colorectal Cancer

Cancer Medicine, 2020
Purpose Nicotinamide n‐methyltransferase (NNMT) has good biochemical activity and epigenetic regulation, and has been reported as a major metabolic regulator of cancer. The goal of this study was to investigate the significance of stromal NNMT expression
Chunhua Song, Hanping Shi, Wenjun Chang
exaly   +2 more sources

Detachment‐Induced FAK‐STAT3‐NNMT Inhibits CTCs Anoikis to Promote Breast Cancer Metastasis by Enhancing Fatty Acid Oxidation [PDF]

Advanced Science
Breast cancer metastasis claims the majority of breast cancer‐related deaths. Anoikis resistance is a key prerequisite for CTCs survival and metastasis. Previous studies have demonstrated that Nicotinamide N‐methyltransferase (NNMT) plays a crucial role ...
Qingchao Tong, Yilei Ma, Yuzhen Gao, Lin Zhou, Luping Lou, Qiang Fang, Sining Fang, Ru Zhao, Jin Zeng, Jun Yang, Guoli Li, Xinyou Xie, Yanzhong Wang, Jun Zhang   +13 more
doaj   +2 more sources

Efficacious Anti-Cancer Drugs Targeting Nicotinamide N-Methyltransferase (NNMT) in Cultured Human Oral Squamous Cell Carcinoma (OSCC) [PDF]

Pharmaceuticals
Background/Objectives: Oral squamous cell carcinoma (OSCC) is a major cause of human cancer. The enzyme, nicotinamide N-methyltransferase (NNMT), is overexpressed in a variety of human cancers, including OSCC.
Brian Maloney, Martyna Kubisztal, Ziqian Ge, Yin Lu, Lisa Strotmann, Adrianna Budziňska, Mary F. Rooney, Marilena Karavyraki, Andrew Knox, Richard K. Porter   +9 more
doaj   +2 more sources

Exosomal NNMT From Peritoneum Lavage Fluid Promotes Peritoneal Metastasis in Gastric Cancer

Kaohsiung Journal of Medical Sciences, 2021
Peritoneal metastasis (PM) is the major cause of recurrence in patients with gastric cancer (GC) and is associated with poor prognosis. The oncogenic role of Nicotinamide N‐methyltransferase (NNMT) in GC has been reported, but the role of secreted NNMT ...
Wen-Cheng Kong, Xinchun Liu, Yu-Qiang Shan   +2 more
exaly   +2 more sources

Nicotinamide N‐Methyltransferase Epigenetically Activates Fibronectin 1 Through H3K9me3 Remodeling in Clear Cell Renal Cell Carcinoma [PDF]

MedComm
Clear cell renal cell carcinoma (ccRCC) is among the most prevalent malignancies of the urinary system. Patients with advanced ccRCC have poor clinical outcomes. This study aimed to investigate the role of nicotinamide N‐methyltransferase (NNMT) in ccRCC.
Lingling Wang, Yueyang Wang, Qizheng Han, Xiao Zhou, Chenxia Wu, Honghe Zhang, Zhiyong Liang, Maode Lai   +7 more
doaj   +2 more sources

Insufficient NNMT promotes autophagy and disrupts progesterone signaling in endometrial stromal cells in recurrent implantation failure by modulating the H3K9me3-ALDH1A3 pathway [PDF]

Cell Death Discovery
Defective endometrial receptivity represents an important factor in recurrent implantation failure (RIF), though its precise regulatory mechanisms remain unclear.
Yifei Song, Shaotong Zhao, Xianping Hou, Jiayuan Chen, Qian Zhang, Shizhen Su, Junhao Yan, Tianxiang Ni   +7 more
doaj   +2 more sources

Cancer‐Associated Fibroblasts Promote Tumor Immunosuppression in Hepatocellular Carcinoma via the NNMT‐ANGPTL4 Axis [PDF]

Advanced Science
Background & Aims: Cancer‐associated fibroblasts (CAFs) drive immunosuppression in hepatocellular carcinoma (HCC). However, their metabolic regulation remains poorly defined.
Shounan Lu, Shanjia Ke, Hongjun Yu, Zhanzhi Meng, Miaoyu Bai, Yanan Xu, Hui Zhu, Jinwen Yang, Baolin Qian, Bing Yin, Chaoqun Wang, Zhigang Feng, Zhongyu Li, Yongzhi Zhou, Zihao Li, Xinglong Li, Yongliang Hua, Yao Fu, Wei Tang, Yaohua Wu, Yong Ma   +20 more
doaj   +2 more sources

Correlation of NNMT and DKK1 Protein Expression With Clinicopathological Characteristics and Prognosis of Breast Cancer

Clinical Medicine Insights: Oncology, 2023
Background: Nicotinamide N-methyltransferase (NNMT) and Dickkopf-1 (DKK1) play an important role in the development of breast cancer, and the purpose of this study was designed to examine the clinical and prognostic significance of NNMT and DKK1 in ...
Yongdong Niu, Haihua Huang, Xiuqian Wu
exaly   +2 more sources

Inhibition of NNMT Enhances Drug Sensitivity in Lung Cancer Cells Through Mediation of Autophagy

Frontiers in Pharmacology
IntroductionThis study aimed to investigate the role of Nicotinamide N-methyltransferase (NNMT) in the drug sensitivity of non-small cell lung cancer (NSCLC) cells, with a focus on its impact on autophagy and resistance to the chemotherapeutic agent ...
Xin You, Chunhui Yang
exaly   +3 more sources