Results 11 to 20 of about 2,900 (147)

Nicotinamide N-Methyltransferase (NNMT): A Novel Therapeutic Target for Metabolic Syndrome

Frontiers in Pharmacology
Metabolic syndrome (MetS) represents a constellation of metabolic abnormalities, typified by obesity, hypertension, hyperglycemia, and hyperlipidemia. It stems from intricate dysregulations in metabolic pathways governing energy and substrate metabolism.
Jiang-Hua Li, Wei-Dong Sun, Ya-Zhong Mei
exaly   +5 more sources

Identification of Biological Functions and Prognostic Value of NNMT in Oral Squamous Cell Carcinoma

Biomolecules, 2022
Background: Nicotinamide N-methyltransferase (NNMT) is a metabolic enzyme that catalyzes the methylation of nicotinamide (NAM) to generate 1-methyl nicotinamide (MNAM).
Weixian Zhang, Yue Jing, Shuai Wang, Yan Wu, Yawei Sun, Jia Zhuang, Xiaofeng Huang, Sheng Chen, Xiaoxin Zhang, Yuxian Song, Qingang Hu, Yanhong Ni   +11 more
doaj   +3 more sources

NNMT Inhibition in Cancer-Associated Fibroblasts Restores Antitumour Immunity [PDF]

Nature
Cancer-associated fibroblasts (CAFs) have a pivotal cancer-supportive role, yet CAF-targeted therapies are lacking1,2. Here, using spatial transcriptomics and single-cell RNA sequencing, we investigate the role of nicotinamide N-methyltransferase (NNMT) in high-grade serous ovarian cancer.
Hua Liang, Qiaoshan Lin, Hardik Shah
exaly   +5 more sources

Nicotinamide N-Methyltransferase (NNMT): A New Hope for Treating Aging and Age-Related Conditions

Metabolites
The complex process of aging leads to a gradual deterioration in the function of cells, tissues, and the entire organism, thereby increasing the risk of disease and death.
Jiang-Hua Li, Wei-Dong Sun, Ya-Zhong Mei
exaly   +3 more sources

Nicotinamide N-Methyltransferase in Cardiovascular Diseases: Metabolic Regulator and Emerging Therapeutic Target [PDF]

Biomolecules
Cardiovascular disease (CVD) remains a leading cause of morbidity and mortality worldwide, arising from complex interactions among metabolic, genetic, and environmental factors.
Jawaria, Yusra Zarlashat, Márton Philippovich, Edit Dósa   +3 more
doaj   +2 more sources

Clinical performance and utility of a NNMT-based urine test for bladder cancer [PDF]

The International Journal of Biological Markers, 2018
Background: Bladder cancer (BC) represents the most common neoplasm of the urinary tract. Although cystoscopy and urine cytology represent the gold standard methods to monitor BC, both procedures have limitations.
Valentina Pozzi, Giulia Di Ruscio, Davide Sartini, Roberto Campagna, Riccardo Seta, Paola Fulvi, Alexia Vici, Giulio Milanese, Gabriele Brandoni, Andrea B. Galosi, Rodolfo Montironi, Monia Cecati, Monica Emanuelli   +12 more
doaj   +3 more sources

Systematic pan-cancer analysis of the nicotinamide n-methyltransferase in human cancer

Frontiers in Genetics, 2022
In several tumors, Nicotinamide N-Methyltransferase (NNMT) was identified as a bridge between methylation metabolism and tumorigenesis and was associated with a poor prognosis.
Li Cao, Wei Wu, Xiangyu Deng, Yizhong Peng, Yangyang Chen, Haoyu Guo, Lutong Wang, Xingyin Li, Zhicai Zhang, Zengwu Shao   +9 more
doaj   +1 more source

Patients with low nicotinamide N-methyltransferase expression benefit significantly from bevacizumab treatment in ovarian cancer

BMC Cancer, 2021
Background The role of nicotinamide N-methyltransferase (NNMT) in ovarian cancer is still elusive. Our aim is to explore the expression of NNMT in ovarian cancer and to assess its association with patient prognosis and treatment response.
Jun Li, Huiran Yue, Hailin Yu, Xin Lu, Xiaohong Xue   +4 more
doaj   +1 more source

Nicotinamide N-methyltransferase: At the crossroads between cellular metabolism and epigenetic regulation

Molecular Metabolism, 2021
Background: The abundance of energy metabolites is intimately interconnected with the activity of chromatin-modifying enzymes in order to guarantee the finely tuned modulation of gene expression in response to cellular energetic status.
Annalisa Roberti, Agustín F. Fernández, Mario F. Fraga   +2 more
doaj   +1 more source

Nicotinamide N-methyltransferase and liver diseases

Genes and Diseases, 2023
Cellular metabolism-induced epigenetic regulation is essential for the maintenance of cellular homeostasis. Nicotinamide N-methyltransferase (NNMT) is emerging as a key point of intersection between cellular metabolism and epigenetic regulation and has a
Guangyu Liang, Ying Li, Yan Lin, Xiao Yang, Jiankun Yang, Shaobo Hu, Anding Liu   +6 more
doaj   +1 more source