Results 21 to 30 of about 2,900 (147)
NNMT (nicotinamide N-methyltransferase) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on NNMT (nicotinamide N-methyltransferase), with data on DNA, on the protein encoded, and where the gene is implicated.
Emanuelli, M +3 more
openaire +2 more sources
Nicotinamide N-Methyltransferase: An Emerging Protagonist in Cancer Macro(r)evolution
Biomolecules, 2021 Nicotinamide N-methyltransferase (NNMT) has progressed from being considered merely a Phase II metabolic enzyme to one with a central role in cell function and energy metabolism. Over the last three decades, a significant body of evidence has accumulated
Richard B. Parsons, Paul D. Facey
doaj +1 more source
Down-regulation of nicotinamide N-methyltransferase induces apoptosis in human breast cancer cells via the mitochondria-mediated pathway. [PDF]
PLoS ONE, 2014 Nicotinamide N-methyltransferase (NNMT) has been found involved in cell proliferation of several malignancies. However, the functional role of NNMT in breast cancer has not been elucidated.
Jun Zhang +4 more
doaj +1 more source
Oncology Reports, 2021 Chemoresistance is the main cause of poor prognosis in colorectal cancer (CRC). Nicotinamide N‑methyltransferase (NNMT) is a metabolic enzyme that is upregulated in various tumor types. It has been reported that NNMT inhibits apoptosis and enhances resistance to 5‑fluorouracil (5‑Fu) via inhibition of the apoptosis signal regulating kinase 1 (ASK1)‑p38
Li, Guoli +8 more
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Discovery of Bisubstrate Inhibitors of Nicotinamide N-Methyltransferase (NNMT) [PDF]
Journal of Medicinal Chemistry, 2018 Nicotinamide N-methyltransferase (NNMT) catalyzes the N-methylation of pyridine-containing compounds using the cofactor S-5'-adenosyl-l-methionine (SAM) as the methyl group donor. Through the regulation of the levels of its substrates, cofactor, and products, NNMT plays an important role in physiology and pathophysiology.
Babault +10 more
openaire +2 more sources
NNMT: A Bad Actor in Fat Makes Good in Liver [PDF]
Cell Metabolism, 2015 High adipose expression of NNMT, an enzyme that converts nicotinamide to 1-methyl-nicotinamide, correlates with adiposity. Though murine NNMT knockdown in fat and liver prevents weight gain on high-fat diet, Hong et al. (2015) now show that high hepatic expression of NNMT improves lipid parameters via SIRT1 stabilization.
Trammell, Samuel A.J., Brenner, Charles
openaire +3 more sources
RNA-mediated gene silencing of nicotinamide N-methyltransferase is associated with decreased tumorigenicity in human oral carcinoma cells. [PDF]
PLoS ONE, 2013 Oral squamous cell carcinoma (OSCC) is the most common type of oral cancer. Despite progress in the treatment of OSCC, overall survival has not improved substantially in the last three decades.
Valentina Pozzi +13 more
doaj +1 more source
Macrocyclic peptides as allosteric inhibitors of nicotinamide N -methyltransferase (NNMT)
RSC Chemical Biology, 2021 Using an mRNA display screening technique, macrocyclic peptides were identified as potent, non-competitive inhibitors of nicotinamide N -methyltransferase.
Matthijs J. van Haren +13 more
openaire +5 more sources
Breast Cancer Research, 2019 Background Nicotinamide N-methyltransferase (NNMT) is overexpressed in various human tumors and involved in the development and progression of several carcinomas. In breast cancer, NNMT was found to be overexpressed in several cell lines.
Yanzhong Wang +11 more
doaj +1 more source
Bisubstrate Inhibitors of Nicotinamide N-Methyltransferase (NNMT) with Enhanced Activity [PDF]
Journal of Medicinal Chemistry, 2019 Nicotinamide N-methyltransferase (NNMT) catalyzes the methylation of nicotinamide to form N-methylnicotinamide. Overexpression of NNMT is associated with a variety of diseases, including a number of cancers and metabolic disorders, suggesting a role for NNMT as a potential therapeutic target.
Yongzhi Gao +10 more
openaire +5 more sources