Results 41 to 50 of about 2,900 (147)

An LNA gapmer antisense oligonucleotide inhibitor of human NNMT. [PDF]

Mol Ther Nucleic Acids
Chen S, Poudel BH, Veedu RN.
europepmc   +3 more sources

Nano Freezing–Thawing of Atlantic Salmon Fillets: Impact on Thermodynamic and Quality Characteristics

Foods, 2023
The presence of magnetic nanoparticles (MNPs) suppresses ice nucleation and growth during freezing and thawing. In this study, the effects of MNPs-assisted cryogenic freezing integrated with MNP-combined microwave thawing (NNMT) on the thermodynamic and ...
Wenxuan Wang, Wenzheng Li, Ying Bu, Xuepeng Li, Wenhui Zhu   +4 more
doaj   +1 more source

NNMT promotes epigenetic remodeling in cancer by creating a metabolic methylation sink [PDF]

Nature Chemical Biology, 2013
Nicotinamide N-methyltransferase (NNMT) is overexpressed in a variety of human cancers, where it contributes to tumorigenesis by a mechanism that is still poorly understood. Here we show using metabolomics that NNMT impairs the methylation potential of cancer cells by consuming methyl units from S-adenosyl methionine to create the stable metabolic ...
Ulanovskaya, Olesya A., Zuhl, Andrea M., Cravatt, Benjamin F.   +2 more
openaire   +2 more sources

Nicotinamide‐N‐methyltransferase is a promising metabolic drug target for primary and metastatic clear cell renal cell carcinoma

Clinical and Translational Medicine, 2022
Background The metabolic enzyme nicotinamide‐N‐methyltransferase (NNMT) is highly expressed in various cancer entities, suggesting tumour‐promoting functions.
Anna Reustle, Lena‐Sophie Menig, Patrick Leuthold, Ute Hofmann, Viktoria Stühler, Christian Schmees, Michael Becker, Mathias Haag, Verena Klumpp, Stefan Winter, Florian A. Büttner, Steffen Rausch, Jörg Hennenlotter, Falko Fend, Marcus Scharpf, Arnulf Stenzl, Jens Bedke, Matthias Schwab, Elke Schaeffeler   +18 more
doaj   +1 more source

Nicotinamide N-Methyltransferase: A Promising Biomarker and Target for Human Cancer Therapy

Frontiers in Oncology, 2022
Cancer cells typically exhibit a tightly regulated program of metabolic plasticity and epigenetic remodeling to meet the demand of uncontrolled cell proliferation.
Xiao-Yu Li, Ya-Nan Pi, Yao Chen, Qi Zhu, Bai-Rong Xia   +4 more
doaj   +1 more source

High-Affinity Alkynyl Bisubstrate Inhibitors of Nicotinamide N-Methyltransferase (NNMT)

Journal of Medicinal Chemistry, 2019
In this work, structure-based rational design led to the development of potent and selective alkynyl bisubstrate inhibitors of NNMT. The reported nicotinamide-SAM conjugate (named NS1 ) features an alkyne as a key design element that closely mimics the linear, 180° transition state geometry found ...
Rocco Policarpo, Ludovic Decultot, Elizabeth May, Petr Kuzmič, Samuel Carlson, Danny Huang, Vincent Chu, Brandon Wright, Saravanakumar Dhakshinamoorthy, Aimo Kannt, Shilpa Rani, Sreekanth Dittakavi, Joseph Panarese, Rachelle Gaudet, Matthew Shair   +14 more
openaire   +5 more sources

Expression profile and prognostic value of NNMT in patients with pancreatic cancer

Oncotarget, 2016
The elevation of Nicotinamide N-methyltransferase (NNMT) has been reported in pancreatic cancer tissues and cell lines, but its clinical and prognostic implications remain controversial. This study aimed at investigating the expression of NNMT in pancreatic benign and malignant tissues and the prognostic value of NNMT in pancreatic cancer.
Xu, Yong, Liu, Ping, Zheng, Dong-Hui, Wu, Nan, Zhu, Lun, Xing, Changying, Zhu, Jin   +6 more
openaire   +3 more sources

Expression of nicotinamide N-methyltransferase in hepatocellular carcinoma is associated with poor prognosis

Journal of Experimental & Clinical Cancer Research, 2009
Background Hepatocellular carcinoma (HCC) is the most common tumor in the adult liver, with high relapse and mortality rates despite diverse treatment modalities.
Do In-Gu, Roh Ji, Kim Seung, Yu Yun-Suk, Lim Eun, Hong Seok, Kim Jongmin, Joh Jae-Won, Kim Dae   +8 more
doaj   +1 more source

Tumor stromal nicotinamide N-methyltransferase overexpression as a prognostic biomarker for poor clinical outcome in early-stage colorectal cancer

Scientific Reports, 2022
In a quest for prognostic biomarkers in early-stage colorectal cancer, we investigated NNMT (nicotinamide N-methyltransferase) in large cohorts of patients.
Makiko Ogawa, Atsushi Tanaka, Kei Namba, Jinru Shia, Julia Y. Wang, Michael H. A. Roehrl   +5 more
doaj   +1 more source

Curcumin Reverses NNMT-Induced 5-Fluorouracil Resistance via Increasing ROS and Cell Cycle Arrest in Colorectal Cancer Cells

Biomolecules, 2021
Nicotinamide N-methyltransferase (NNMT) plays multiple roles in improving the aggressiveness of colorectal cancer (CRC) and enhancing resistance to 5-Fluorouracil (5-FU), making it an attractive therapeutic target.
Guoli Li, Sining Fang, Xiao Shao, Yejia Li, Qingchao Tong, Beibei Kong, Lifen Chen, Yanzhong Wang, Jun Yang, Haitao Yu, Xinyou Xie, Jun Zhang   +11 more
doaj   +1 more source