Results 51 to 60 of about 2,900 (147)

Nicotinamide N-Methyltransferase in Head and Neck Tumors: A Comprehensive Review

Biomolecules, 2021
The head and neck tumors (HNT) are a heterogeneous group of diseases ranging from benign to malignant lesions, with distinctive molecular and clinical behaviors. Several studies have highlighted the presence of an altered metabolic phenotype in HNT, such
Lucrezia Togni, Marco Mascitti, Davide Sartini, Roberto Campagna, Valentina Pozzi, Eleonora Salvolini, Annamaria Offidani, Andrea Santarelli, Monica Emanuelli   +8 more
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Nicotinamide N-methyltransferase inhibits autophagy induced by oxidative stress through suppressing the AMPK pathway in breast cancer cells

Cancer Cell International, 2020
Background Nicotinamide N-methyltransferase (NNMT) is highly expressed in several cancers and can regulate cell epigenetic status and various cell metabolism pathways, such as ATP synthesis and cellular stress response. We reported in our previous papers
Haitao Yu, Xi Zhou, Yanzhong Wang, Xucheng Huang, Jun Yang, Jin Zeng, Guoli Li, Xinyou Xie, Jun Zhang   +8 more
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NNMT overexpression is an adverse prognostic factor in uterine leiomyosarcoma

Turkish Journal of Medical Sciences
Background/Aim: Uterine leiomyosarcomas (uLMS) are extremely rare high-grade tumors with a poor prognosis. Their etiopathogenesis remains largely unknown. The uterus is the most frequent site for LMS. uLMS and uterine leiomyoma (uLM) must frequently be differentiated in patients with a uterine mass.
TÜRKMEN, Osman, MÜFTÜOĞLU, Kamil Hakan, DİNÇER, Nazmiye, ÇELİK, Zeliha Esin, AKAR İNAN, Serra   +4 more
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Overexpression of NNMT in Glioma Aggravates Tumor Cell Progression: An Emerging Therapeutic Target

Cancers, 2022
Purpose: Increasing evidence has revealed that nicotinamide N-methyltransferase (NNMT) is a key factor influencing the prognosis of tumors. The present study aimed to investigate the role of NNMT in glioma and to elucidate the associated functional mechanisms.
Wei Sun, Yongxiang Zou, Zheng Cai, Jinxiang Huang, Xinjie Hong, Qiang Liang, Weilin Jin   +6 more
openaire   +2 more sources

NNMT Is an Immune-Related Prognostic Biomarker That Modulates the Tumor Microenvironment in Pan-Cancer

Disease Markers, 2022
Emerging evidence has revealed the significant roles of nicotinamide n-methyltransferase (NNMT) in cancer initiation, development, and progression; however, a pan-cancer analysis of NNMT has not been conducted. In this study, we first thoroughly investigated the expression and prognostic significance of NNMT and the relationship between NNMT and the ...
Wenxiu Liu, Meng Zhu, Xiaoming Li, Limian Er, Shengmian Li   +4 more
openaire   +2 more sources

Prognostic Value of Nicotinamide N-Methyltransferase Expression in Patients With Solid Tumors: A Systematic Review and Meta-Analysis

Frontiers in Physiology, 2018
Background: Nicotinamide N-methyltransferase (NNMT) is an enzyme that catalyzes N-methylation of pyridine-containing compounds. NNMT is upregulated in many types of solid tumors, suggesting the potential for its use as a tumor biomarker.
Shimeng Li, Lu Qiao, Zhaowei Yang, Chengyan He   +3 more
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NNMT inhibition counteracts tubular senescence and fibrosis in early stages of chronic kidney disease

Cell Reports
Summary: Chronic kidney disease (CKD) is projected to become the fifth leading cause of mortality by 2040. Tubular senescence drives kidney fibrosis, but current treatments do not target senescent cells. Here, we identify nicotinamide-N-methyltransferase
Lucie Chanvillard, Hildo C. Lantermans, Christopher Wall, Jonathan Thevenet, Loes M. Butter, Loic Tauzin, Nike Claessen, Stefan Christen, James A. Holzwarth, Sonia Karaz, Steve Lassueur, Giulia Lizzo, José Luis Sanchez-Garcia, Sylviane Métairon, Valentina Ferro, Sofia Moco, Erik J.M. van Bommel, Michael J.B. van Baar, Anne C. Hesp, Daniel H. van Raalte, Joris J.T.H. Roelofs, Harshini Neelakantan, Stanley J. Watowich, Matthew J. Sanders, Jerome N. Feige, Vincenzo Sorrentino, Alessandra Tammaro   +26 more
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NNMT expression in preeclampsia: Analyses on placental tissues and cell lines

Placenta
Preeclampsia (PE) is a multisystem disorder characterized by new onset hypertension and proteinuria during pregnancy. Nicotinamide N-methyltransferase (NNMT) is an enzyme that catalyzes the N-methylation of nicotinamide (NAM) to form 1-methylnicotinamide (MNA) and S-adenosyl-L-homocysteine (SAH). The aim of this study was to investigate NNMT expression
Giovanni Tossetta, Roberto Campagna, Sonia Fantone, Nicoletta Di Simone, Veronica Pompei, Stefano Raffaele Giannubilo, Andrea Ciavattini, Davide Sartini, Monica Emanuelli, Daniela Marzioni   +9 more
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Macrocyclic Peptides as Allosteric Inhibitors of Nicotinamide N-Methyltransferase (NNMT) [PDF]

, 2020
Nicotinamide N -methyltransferase (NNMT) methylates nicotinamide to form 1-methylnicotinamide using S -adenosyl-l-methionine (SAM) as the methyl donor. The complexity of the role of NNMT in healthy and disease states is slowly being elucidated and provides ...
Matthijs J. van Haren, Yurui Zhang, Ned Buijs, Vito Thijssen, Davide Sartini, Monica Emanuelli, Seino Jongkees, Nathaniel Martin   +7 more
openaire   +1 more source

NAD+ metabolism enzyme NNMT in cancer-associated fibroblasts drives tumor progression and resistance to immunotherapy by modulating macrophages in urothelial bladder cancer

Journal for ImmunoTherapy of Cancer
Background This study comprehensively investigates the association between the expression of nicotinamide N-methyltransferase (NNMT) and clinical outcomes of urothelial bladder cancer (UBC), as well as the molecular mechanisms by which NNMT in cancer ...
Jian Huang, Bo Wang, Dong Yan, Tianxin Lin, Lu Pei, Hao Yu, Wang He, Kaiwen Li, Meihua Yang, Weibin Hou, Honghui Zeng, Xin-Ke Zhang, Long Huang, Haide Qin   +13 more
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