Results 31 to 40 of about 2,900 (147)

Effects of Nicotinamide N-Methyltransferase on PANC-1 Cells Proliferation, Metastatic Potential and Survival Under Metabolic Stress

Cellular Physiology and Biochemistry, 2015
Background: Aberrant expression of Nicotinamide N-methyltransferase (NNMT) has been reported in pancreatic cancer. However, the role of NNMT in pancreatic cancer development remains elusive.
Tao Yu, Yong-Tao Wang, Pan Chen, Yu-Hua Li, Yi-Xin Chen, Hang Zeng, Ai-Ming Yu, Min Huang, Hui-Chang Bi   +8 more
doaj   +1 more source

Targeting nicotinamide N-methyltransferase overcomes resistance to EGFR-TKI in non-small cell lung cancer cells

Cell Death Discovery, 2022
Activating mutations of epidermal growth factor receptor (EGFR) contributes to the progression of non-small cell lung cancer (NSCLC). EGFR tyrosine kinase inhibitor (TKI)-targeted therapy has become the standard treatment for NSCLC patients with EGFR ...
Jun Wang, Xi Liu, Yuanfeng Huang, Pan Li, Minqiang Yang, Shanshan Zeng, Danyang Chen, Qian Wang, Hao Liu, Kai Luo, Jin Deng   +10 more
doaj   +1 more source

NNMT promotes the progression of intrahepatic cholangiocarcinoma by regulating aerobic glycolysis via the EGFR-STAT3 axis

Oncogenesis, 2022
Nicotinamide N-methyltransferase (NNMT), a member of the N-methyltransferase family, plays an important role in tumorigenesis. However, its expression and biological functions in intrahepatic cholangiocarcinoma (iCCA) remain to be established.
Shounan Lu, Shanjia Ke, Chaoqun Wang, Yanan Xu, Zihao Li, Keda Song, Miaoyu Bai, Menghua Zhou, Hongjun Yu, Bing Yin, Xinglong Li, Zhigang Feng, Yongliang Hua, Shangha Pan, Hongchi Jiang, Linqiang Li, Yaohua Wu, Yong Ma   +17 more
doaj   +1 more source

Elucidating the role of nicotinamide N-methyltransferase-p53 axis in the progression of chronic kidney disease [PDF]

PeerJ, 2023
Background Chronic kidney disease (CKD) is a significant global health issue characterized by progressive loss of kidney function. Renal interstitial fibrosis (TIF) is a common feature of CKD, but current treatments are seldom effective in reversing TIF.
Xin Zhen, Yuxiang Sun, Hongchun Lin, Yuebo Huang, Tianwei Liu, Yuanqing Li, Hui Peng   +6 more
doaj   +2 more sources

Lower serum nicotinamide N-methyltransferase levels in patients with bipolar disorder during acute episodes compared to healthy controls: a cross-sectional study

BMC Psychiatry, 2020
Background Nicotinamide N-methyltransferase (NNMT) has been implicated in the pathogenesis of neuropsychiatric diseases. Bipolar disorder (BD) is associated with metabolic abnormalities and NNMT regulates energy metabolism and may also exert a causal ...
Qing Hu, Farong Liu, Luyin Yang, Zanxi Fang, Jue He, Wenqiang Wang, Pan You   +6 more
doaj   +1 more source

NNMT: Mean-Field Based Analysis Tools for Neuronal Network Models

Frontiers in Neuroinformatics, 2022
Mean-field theory of neuronal networks has led to numerous advances in our analytical and intuitive understanding of their dynamics during the past decades. In order to make mean-field based analysis tools more accessible, we implemented an extensible, easy-to-use open-source Python toolbox that collects a variety of mean-field methods for the leaky ...
Moritz Layer, Moritz Layer, Johanna Senk, Simon Essink, Simon Essink, Alexander van Meegen, Alexander van Meegen, Hannah Bos, Moritz Helias, Moritz Helias   +9 more
openaire   +5 more sources

Complex roles of nicotinamide N-methyltransferase in cancer progression

Cell Death and Disease, 2022
Nicotinamide N-methyltransferase (NNMT) is an intracellular methyltransferase, catalyzing the N-methylation of nicotinamide (NAM) to form 1-methylnicotinamide (1-MNAM), in which S-adenosyl-l-methionine (SAM) is the methyl donor.
Weixuan Wang, Changmei Yang, Tianxiang Wang, Haiteng Deng   +3 more
doaj   +1 more source

Proteomics reveals NNMT as a master metabolic regulator of cancer-associated fibroblasts [PDF]

Nature, 2019
High-grade serous carcinoma has a poor prognosis, owing primarily to its early dissemination throughout the abdominal cavity. Genomic and proteomic approaches have provided snapshots of the proteogenomics of ovarian cancer1,2, but a systematic examination of both the tumour and stromal compartments is critical in understanding ovarian cancer metastasis.
Eckert, Mark A, Coscia, Fabian, Chryplewicz, Agnieszka, Chang, Jae Won, Hernandez, Kyle M, Pan, Shawn, Tienda, Samantha M, Nahotko, Dominik A, Li, Gang, Blaženović, Ivana, Lastra, Ricardo R, Curtis, Marion, Yamada, S Diane, Perets, Ruth, McGregor, Stephanie M, Andrade, Jorge, Fiehn, Oliver, Moellering, Raymond E, Mann, Matthias, Lengyel, Ernst   +19 more
openaire   +5 more sources

Nicotinamide N-Methyl Transferase as a Predictive Marker of Tubular Fibrosis in CKD

International Journal of General Medicine, 2023
Qinglin Ye,* Guiling Xu,* Haizhen Huang,* Shuting Pang, Boji Xie, Bingmei Feng, Peng Liang, Yijie Qin, Siji Li, Yin Luo, Chao Xue, Wei Li Department of Nephrology, The Second Affiliated Hospital of Guangxi Medical University, Nanning, People ...
Ye Q, Xu G, Huang H, Pang S, Xie B, Feng B, Liang P, Qin Y, Li S, Luo Y, Xue C, Li W   +11 more
doaj  

The significance of NAD + metabolites and nicotinamide N-methyltransferase in chronic kidney disease

Scientific Reports, 2022
Dysregulation of nicotinamide adenine dinucleotide (NAD +) metabolism contributes to the initiation and progression of age-associated diseases, including chronic kidney disease (CKD).
Rina Takahashi, Takeshi Kanda, Motoaki Komatsu, Tomoaki Itoh, Hitoshi Minakuchi, Hidenori Urai, Tomohiro Kuroita, Shuhei Shigaki, Tasuku Tsukamoto, Naoko Higuchi, Minoru Ikeda, Risa Yamanaka, Norito Yoshimura, Takashi Ono, Hideo Yukioka, Kazuhiro Hasegawa, Hirobumi Tokuyama, Shu Wakino, Hiroshi Itoh   +18 more
doaj   +1 more source