Results 61 to 70 of about 2,900 (147)

Elevated N‐methyltransferase expression induced by hepatic stellate cells contributes to the metastasis of hepatocellular carcinoma via regulation of the CD44v3 isoform

Molecular Oncology, 2019
The cross‐talk between hepatic stellate cells (HSCs) and hepatic carcinoma cells contributes to hepatocellular carcinoma (HCC) progression, but the underlying mechanism is largely unknown.
Jie Li, Song You, Sheng Zhang, Qing Hu, Fuqiang Wang, Xiaoqin Chi, Wenxiu Zhao, Chengrong Xie, Changmao Zhang, Yaqi Yu, Jianmin Liu, Yue Zhao, Pingguo Liu, Yi Zhang, Xujin Wei, Qiu Li, Xiaomin Wang, Zhenyu Yin   +17 more
doaj   +1 more source

Pan-cancer analysis combined with experiments predicts NNMT as a therapeutic target for human cancers

Discover Oncology
The identification of effective therapeutic targets plays a pivotal role in advancing cancer treatment outcomes. We employed a comprehensive pan-cancer analysis, complemented by experimental validation, to explore the potential of Nicotinamide N ...
Hua Huang, Lianchun Su, Ruihao Zhang, Di Wu, Chen Ding, Chen Chen, Guangsheng Zhu, Peijun Cao, Xuanguang Li, Yongwen Li, Hongyu Liu, Jun Chen   +11 more
doaj   +1 more source

Self-amplifying nicotinamide N-methyltransferase feedback loops: Drivers of anticancer drug resistance and therapeutic opportunities

Journal of Pharmaceutical Analysis
Drug resistance poses a significant challenge in cancer therapy, undermining treatment efficacy and patient survival. Nicotinamide N-methyltransferase (NNMT), a pivotal cytoplasmic enzyme, plays a crucial role in mediating drug resistance by linking ...
Shuang-Zhou Bi, Xiang-Li Ni, Wei-Dong Sun, Chen-Ying Zhang, An Liu, Shi-Yan Lai, Jiang-Hua Li   +6 more
doaj   +1 more source

NNMT promotes acquired EGFR-TKI resistance by forming EGR1 and lactate-mediated double positive feedback loops in non-small cell lung cancer

Molecular Cancer
Background Epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) are remarkably effective for treating EGFR-mutant non-small cell lung cancer (NSCLC).
Jiali Dai, Xiyi Lu, Chang Zhang, Tianyu Qu, Wei Li, Jun Su, Renhua Guo, Dandan Yin, Pingping Wu, Liang Han, Erbao Zhang   +10 more
doaj   +1 more source

Nicotinamide N‐methyltransferase expression decreases in iron overload, exacerbating toxicity in mouse hepatocytes

Hepatology Communications, 2017
Iron overload causes the generation of reactive oxygen species that can lead to lasting damage to the liver and other organs. The goal of this study was to identify genes that modify the toxicity of iron overload.
Tiago Koppe, Bonnie Patchen, Aaron Cheng, Manoj Bhasin, Chris Vulpe, Robert E. Schwartz, Jose Maria Moreno‐Navarrete, Jose Manuel Fernandez‐Real, Pavlos Pissios, Paula G. Fraenkel   +9 more
doaj   +1 more source

NNMT/1-MNA protects against hepatic ischemia-reperfusion injury through the AKT/FOXO1/ANGPT2/JNK axis

Nature Communications
Hepatic ischemia‒reperfusion injury (HIRI) occurs during liver surgery, contributing to postoperative complications such as liver failure, prolonged hospital stays, and increased morbidity and mortality rates.
Bing Yin, Baolin Qian, Hongjun Yu, Shanjia Ke, Zihao Li, Yongliang Hua, Shounan Lu, Chaoqun Wang, Mengxin Li, Sixun Guo, Zhongyu Li, Yongzhi Zhou, Zhanzhi Meng, Xinglong Li, Yanan Xu, Zhigang Feng, Miaoyu Bai, Yao Fu, Wei Tang, Shangyu Hong, Yong Ma   +20 more
doaj   +1 more source

Reply to: “NNMT aggravates hepatic steatosis but alleviates liver injury in alcoholic liver disease” and “Two sides of NNMT in alcoholic and non-alcoholic fatty liver development” [PDF]

Journal of Hepatology, 2021
Qing Song, Jun Wang, Alexandra Griffiths, Zhenyuan Song   +3 more
openaire   +2 more sources

Overexpressed nicotinamide N‑methyltransferase in endometrial stromal cells induced by macrophages and estradiol contributes to cell proliferation in endometriosis

Cell Death Discovery
Endometriosis, an estrogen-dependent chronic inflammatory condition, afflicts reproductive-aged women. However, the underlying pathological mechanisms remain to be elucidated.
Shuhui Hou, Hui Xu, Shating Lei, Dong Zhao   +3 more
doaj   +1 more source

Nicotinamide N-methyltransferase (NNMT) [PDF]

Science-Business eXchange, 2014
openaire   +1 more source

Two sides of NNMT in alcoholic and non-alcoholic fatty liver development [PDF]

Journal of Hepatology, 2021
Yuan Zhang, Zhouping Lu, Weijia Zeng, Jianyuan Zhao, Xiangyu Zhou   +4 more
openaire   +2 more sources