Nicotinamide N-methyltransferase as a therapeutic target in taxane-resistant castration-resistant prostate cancer [PDF]
Cell Death DiscoveryDrug resistance in patients remains a significant obstacle to successful treatment, even with improvements in cancer treatment strategies. Resistance to taxanes, such as docetaxel (Dtx) and cabazitaxel (Cbz), frequently emerges in castration resistant ...
Buse Cevatemre +7 more
doaj +2 more sources
Nicotinamide N‐Methyltransferase Epigenetically Activates Fibronectin 1 Through H3K9me3 Remodeling in Clear Cell Renal Cell Carcinoma [PDF]
MedCommClear cell renal cell carcinoma (ccRCC) is among the most prevalent malignancies of the urinary system. Patients with advanced ccRCC have poor clinical outcomes. This study aimed to investigate the role of nicotinamide N‐methyltransferase (NNMT) in ccRCC.
Lingling Wang +7 more
doaj +2 more sources
Nicotinamide N-methyltransferase inhibition mimics and boosts exercise-mediated improvements in muscle function in aged mice [PDF]
Scientific ReportsHuman hallmarks of sarcopenia include muscle weakness and a blunted response to exercise. Nicotinamide N-methyltransferase inhibitors (NNMTis) increase strength and promote the regenerative capacity of aged muscle, thus offering a promising treatment for
Andrea L. Dimet-Wiley +8 more
doaj +2 more sources
Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling [PDF]
Molecular OncologyKinase inhibitors have achieved great success in targeted cancer therapy, yet the evident limitations in their effectiveness persist due to therapeutic resistance.
Zhanwu Hou +5 more
doaj +2 more sources
Nicotinamide N-methyltransferase (NNMT) regulates the glucocorticoid signaling pathway during the early phase of adipogenesis [PDF]
Scientific Reports, 2023 Obesity is associated with adipose tissue dysfunction through the differentiation and expansion of pre-adipocytes to adipocytes (hyperplasia) and/or increases in size of pre-existing adipocytes (hypertrophy).
Annalisa Roberti +13 more
doaj +2 more sources
Novel tricyclic small molecule inhibitors of Nicotinamide N-methyltransferase for the treatment of metabolic disorders [PDF]
Scientific Reports, 2022 Nicotinamide N-methyltransferase (NNMT) is a metabolic regulator that catalyzes the methylation of nicotinamide (Nam) using the co-factor S-adenosyl-L-methionine to form 1-methyl-nicotinamide (MNA).
Sven Ruf +27 more
doaj +2 more sources
Nicotinamide N-Methyltransferase (NNMT): A New Hope for Treating Aging and Age-Related Conditions [PDF]
MetabolitesThe complex process of aging leads to a gradual deterioration in the function of cells, tissues, and the entire organism, thereby increasing the risk of disease and death.
Jing-Jing Li +5 more
doaj +2 more sources
Nicotinamide N-Methyltransferase:Genomic Connection to Disease [PDF]
International Journal of Tryptophan Research, 2020 Single-nucleotide polymorphisms (SNPs) in and around the nicotinamide N-methyltransferase (NNMT) gene are associated with a range of cancers and other diseases and conditions.
Parsons, Richard B. +4 more
core +4 more sources
Nicotinamide‐N‐methyltransferase is a promising metabolic drug target for primary and metastatic clear cell renal cell carcinoma [PDF]
Clinical and Translational Medicine, 2022 Background The metabolic enzyme nicotinamide‐N‐methyltransferase (NNMT) is highly expressed in various cancer entities, suggesting tumour‐promoting functions.
Anna Reustle +18 more
doaj +2 more sources
Targeting nicotinamide N-methyltransferase overcomes resistance to EGFR-TKI in non-small cell lung cancer cells [PDF]
Cell Death Discovery, 2022 Activating mutations of epidermal growth factor receptor (EGFR) contributes to the progression of non-small cell lung cancer (NSCLC). EGFR tyrosine kinase inhibitor (TKI)-targeted therapy has become the standard treatment for NSCLC patients with EGFR ...
Jun Wang +10 more
doaj +2 more sources