NNMT (nicotinamide N-methyltransferase) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2010 Review on NNMT (nicotinamide N-methyltransferase), with data on DNA, on the protein encoded, and where the gene is ...
Pozzi, V +11 more
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NicotinamideN-Methyltransferase in Health and Cancer [PDF]
International Journal of Tryptophan Research, 2017 Over the past decade, the roles of nicotinamide N-methyltransferase and its product 1-methyl nicotinamide have emerged from playing merely minor roles in phase 2 xenobiotic metabolism as actors in some of the most important scenes of human life.
Parsons, Richard Bramwell +7 more
core +5 more sources
The significance of NAD + metabolites and nicotinamide N-methyltransferase in chronic kidney disease [PDF]
Scientific Reports, 2022 Dysregulation of nicotinamide adenine dinucleotide (NAD +) metabolism contributes to the initiation and progression of age-associated diseases, including chronic kidney disease (CKD).
Rina Takahashi +18 more
doaj +2 more sources
Nicotinamide N-Methyltransferase in Cardiovascular Diseases: Metabolic Regulator and Emerging Therapeutic Target [PDF]
BiomoleculesCardiovascular disease (CVD) remains a leading cause of morbidity and mortality worldwide, arising from complex interactions among metabolic, genetic, and environmental factors.
Jawaria +3 more
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Novel Inhibitors of Nicotinamide-N-Methyltransferase for the Treatment of Metabolic Disorders [PDF]
Molecules, 2021 Nicotinamide-N-methyltransferase (NNMT) is a cytosolic enzyme catalyzing the transfer of a methyl group from S-adenosyl-methionine (SAM) to nicotinamide (Nam). It is expressed in many tissues including the liver, adipose tissue, and skeletal muscle.
Aimo Kannt +9 more
doaj +2 more sources
Remote solid cancers rewire hepatic nitrogen metabolism via host nicotinamide-N-methyltransferase [PDF]
Nature Communications, 2022 The presence of cancer can induce systemic disruption of the host homeostasis. Here, the authors show that different solid tumours remotely increase hepatic nicotinamide-Nmethyltransferase disrupting the host urea cycle metabolism in the liver.
Rin Mizuno +16 more
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Elucidating the role of nicotinamide N-methyltransferase-p53 axis in the progression of chronic kidney disease [PDF]
PeerJ, 2023 Background Chronic kidney disease (CKD) is a significant global health issue characterized by progressive loss of kidney function. Renal interstitial fibrosis (TIF) is a common feature of CKD, but current treatments are seldom effective in reversing TIF.
Xin Zhen +6 more
doaj +3 more sources
Nicotinamide-N-methyltransferase controls behavior, neurodegeneration and lifespan by regulating neuronal autophagy. [PDF]
PLoS Genetics, 2018 Nicotinamide N-methyl-transferase (NNMT) is an essential contributor to various metabolic and epigenetic processes, including the regulating of aging, cellular stress response, and body weight gain. Epidemiological studies show that NNMT is a risk factor
Kathrin Schmeisser, J Alex Parker
doaj +2 more sources
Nicotinamide N-Methyltransferase (NNMT) and Liver Cancer: From Metabolic Networks to Therapeutic Targets [PDF]
BiomoleculesHepatocellular carcinoma (HCC), the predominant form of primary liver cancer, remains a global health challenge with limited therapeutic options and high mortality rates. Despite advances in understanding its molecular pathogenesis, the role of metabolic
Shi-Yan Lai +6 more
doaj +2 more sources
Nicotinamide N-Methyltransferase as Promising Tool for Management of Gastrointestinal Neoplasms [PDF]
Biomolecules, 2022 Gastrointestinal (GI) neoplasms include esophageal, gastric, colorectal, hepatic, and pancreatic cancers. They are characterized by asymptomatic behavior, being responsible for diagnostic delay.
Valentina Pozzi +3 more
doaj +2 more sources