Results 31 to 40 of about 222,121 (295)

Pyrroloquinoline quinone increases the expression and activity of Sirt1 and -3 genes in HepG2 cells. [PDF]

, 2015
Sirtuin (Sirt) 1 and Sirt 3 are nicotinamide adenine dinucleotide ((+))-dependent protein deacetylases that are important to a number of mitochondrial-related functions; thus, identification of sirtuin activators is important. Herein, we hypothesize that
Arguelles, Andrix, Bedi, Yudhishtar Singh, Chau, Jason, Choudhury, Mahua, Meruvu, Sunitha, Rucker, Robert, Zhang, Jian   +6 more
core   +1 more source

Improved catalytic activity of ruthenium–arene complexes in the reduction of NAD+ [PDF]

, 2012
A series of neutral Ru-II half-sandwich complexes of the type [(eta(6)-arene)Ru(N,N')Cl] where the arene is para-cymene (p-cym), hexamethylbenzene (hmb), biphenyl (bip), or benzene (bn) and N,N' is N-(2-aminoethyl) -4-(trifluoromethyl)benzenesulfonamide (
Abraha Habtemariam, Canivet J., Carrión M. C., Chen Q., Clayden J., Creutz C., Dibenedetto A., Fish R. H., Grau M. M., Grimme S., Guy J. Clarkson, Habtemariam A., Haquette P., Held M., Hileman E. O., Joan J. Soldevila-Barreda, Khan J. A., Kim Y. H., Leiva C., Li X., Lo H. C., Maenaka Y., Martins J. E. D., Matharu D. S., Matthew C. K., Morris R. E., Neese F., Noyori R., Peacock A. F. A., Peter J. Sadler, Pieter C. A. Bruijnincx, Robert J. Deeth, Robertson A., Romain C., Ruppert R., Sandoval C. A., Schäfer A., Sheldrick G. M., Sinnecker S., Tan J., Thai T., Wang C., Wang F., Watanabe M., Weckbecker A., Weigend F., Wolfson A., Wu J., Wu X., Yan Y. K., Ying W., Zhou Z., Zhou Z.   +52 more
core   +6 more sources

Effect of 8 Weeks of Endurance Training on S6K1 and 4EBP1 Proteins Content in the Left Ventricle of the Heart of Diabetic Rats Induced by Streptozotocin and Nicotinamide

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd, 2021
Introduction: Physiological hypertrophy of the heart is dependent on cellular pathways and important proteins such as the ribosomal protein S6 kinase beta-1 (S6K1) and  eukaryotic translation intiation factor4E-binding protein-1(4EBP1).
Maryam Shabani, Mohammad Sherafati Moghadam, Kamilia Moghaddami   +2 more
doaj  

Combined Cutaneous Therapy Using Biocompatible Metal-Organic Frameworks

Nanomaterials, 2020
Combined therapies emerge as an interesting tool to overcome limitations of traditional pharmacological treatments (efficiency, side effects). Among other materials, metal-organic frameworks (MOFs) offer versatilities for the accommodation of multiple ...
Seyed Dariush Taherzade, Sara Rojas, Janet Soleimannejad, Patricia Horcajada   +3 more
doaj   +1 more source

Colorimetric methods for rapid determination of pyrazinamide resistance

International Journal of Mycobacteriology, 2020
Background: Because pyrazinamide (PZA) is only effective for Mycobacterium tuberculosis at an acidic pH, susceptibility tests are more difficult to perform than those for other anti-tuberculosis (TB) drugs.
Ahmet Ugur Akbal, Belma Durupinar, Ahmet Yilmaz Coban   +2 more
doaj   +1 more source

Structure, function and inhibition of poly(ADP-ribose)polymerase, member 14 (PARP14) [PDF]

, 2018
Poly(ADP-ribose)polymerase, member 14 (PARP14, alternatively named ARTD8, BAL2, and COAST6) is an intracellular mono(ADP-ribosyl) transferase. PARP14 transfers a negatively charged ADP-ribose unit from a donor NAD+ molecule onto a target protein, post ...
Levonis, Stephan M, Schweiker, Stephanie S, Sherry, Madeleine, Tauber, Amanda   +3 more
core   +1 more source

Simvastatin-Nicotinamide Co-Crystals: Formation, Pharmaceutical Characterization and in vivo Profile

Drug Design, Development and Therapy, 2020
Fahad Mehmood Khan,1 Mahmood Ahmad,2 Hafiz Arfat Idrees1 1Faculty of Pharmacy and Alternative Medicine, The Islamia University of Bahawalpur, Punjab 63100, Pakistan; 2Faculty of Pharmacy, University of Central Punjab, Punjab 54000, PakistanCorrespondence:
Khan FM, Ahmad M, Idrees HA
doaj  

Anti-cancer and immunomodulatory evaluation of new nicotinamide derivatives as potential VEGFR-2 inhibitors and apoptosis inducers: in vitro and in silico studies

Journal of Enzyme Inhibition and Medicinal Chemistry, 2022
New nicotinamide derivatives 6, 7, 10, and 11 were designed and synthesised based on the essential features of the VEGFR-2 inhibitors. Compound 10 revealed the highest anti-proliferative activities with IC50 values of 15.4 and 9.8 µM against HCT-116 and ...
Reda G. Yousef, Alaa Elwan, Ibraheem M. M. Gobaara, Ahmed B. M. Mehany, Wagdy M. Eldehna, Souad A. El-Metwally, Bshra A. Alsfouk, Eslam B. Elkaeed, Ahmed M. Metwaly, Ibrahim H. Eissa   +9 more
doaj   +1 more source

Birth asphyxia as the major complication in newborns: Moving towards improved individual outcomes by prediction, targeted prevention and tailored medical care [PDF]

, 2011
Perinatal Asphyxia—oxygen deficit at delivery—can lead to severe hypoxic ischaemic organ damage in newborns followed by a fatal outcome or severe life-long pathologies.
CEBIOGLU M, GOLUBNITSCHAJA O, HERRERA-MARSCHITZ M, MORELLI M, YEGHIAZARYAN K   +4 more
core   +1 more source

Chitin Nanofibril-Nanolignin Complexes as Carriers of Functional Molecules for Skin Contact Applications

Nanomaterials, 2022
Chitin nanofibrils (CN) and nanolignin (NL) were used to embed active molecules, such as vitamin E, sodium ascorbyl phosphate, lutein, nicotinamide and glycyrrhetinic acid (derived from licorice), in the design of antimicrobial, anti-inflammatory and ...
Maria-Beatrice Coltelli, Pierfrancesco Morganti, Valter Castelvetro, Andrea Lazzeri, Serena Danti, Bouchra Benjelloun-Mlayah, Alessandro Gagliardini, Alessandra Fusco, Giovanna Donnarumma   +8 more
doaj   +1 more source