Results 31 to 40 of about 159,186 (304)
Nicotinamide prevention in diabetes-induced alterations in the rat liver
Endocrine Regulations, 2023 Objective. The study was performed to elucidate whether nicotinamide (NAm) can attenuate the diabetes-induced liver damage by correction of ammonia detoxifying function and disbalance of NAD-dependent processes in diabetic rats.
Kuchmerovska Tamara +5 more
doaj +1 more source
Synthesis of phosphodiester-type nicotinamide adenine dinucleotide analogs
, 2009 Fourteen phosphodiester-type beta-nicotinamide adenine dinucleotide (NAD+) analogs were prepared starting from nicotinamide. The phosphodiester linkage was effectively assembled in 69-93% yields via condensation reaction between 2'.3'-di-O-acetyl ...
Wu, Siguo +8 more
core +1 more source
Toxins, 2016 N-methyl-2-pyridone-5-carboxamide (2PY, a major metabolite of nicotinamide, NAM) was recently identified as a uremic toxin. Recent interventional trials using NAM to treat high levels of phosphorus in end-stage renal disease have highlighted new ...
Aurélie Lenglet +10 more
doaj +1 more source
Biosynthesis of squalene and cholesterol by cell-free extracts of adult rat brain
Journal of Lipid Research, 1969 Cell-free extracts of adult rat brain incubated with mevalonic acid-2-14C synthesize 14C-labeled nonsaponifiable fractions consisting largely of squalene-14C.
M.T. Kelley +3 more
doaj +1 more source
Nicotinamide-Containing Di- and Trinucleotides as Chemical Tools for Studies of NAD-Capped RNAs
, 2018 We report the chemical synthesis of a set of nicotinamide adenine dinucleotide (NAD) cap analogues containing chemical modifications that reduce their susceptibility to NAD-RNA-degrading enzymes.
Megerditch Kiledjian (2407492) +15 more
core +1 more source
Nanomaterials, 2022 Chitin nanofibrils (CN) and nanolignin (NL) were used to embed active molecules, such as vitamin E, sodium ascorbyl phosphate, lutein, nicotinamide and glycyrrhetinic acid (derived from licorice), in the design of antimicrobial, anti-inflammatory and ...
Maria-Beatrice Coltelli +8 more
doaj +1 more source
Science in the News - Nicotinamide Exacerbates Motor Symptoms of Parkinson\u27s Disease in Mice. [PDF]
, 2018 Melão, A. (2018, October 17). Nicotinamide Exacerbates Motor Symptoms of Parkinson\u27s Disease in Mice. Retrieved November 7, 2017, from https://parkinsonsnewstoday.com/2018/10/10/nicotinamide-exacerbates-motor-symptoms-of-parkinsons-disease-in ...
Tabbaa, Layth A
core
Kinetic Mechanism of Nicotinamide N-Methyltransferase.
, 2018 Nicotinamide N-methyltransferase (NNMT) catalyzes the transfer of a methyl group from S-adenosylmethionine (SAM) to nicotinamide, pyridine, and other structural analogues.
Thompson, Paul R, Loring, Heather S.
core +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh +11 more
wiley +1 more source