Results 31 to 40 of about 155,595 (297)

Deracemization of Axially Chiral Nicotinamides by Dynamic Salt Formation with Enantiopure Dibenzoyltartaric Acid (DBTA)

Molecules, 2013
Dynamic atroposelective resolution of chiral salts derived from oily racemic nicotinamides and enantiopure dibenzoyltartaric acid (DBTA) was achieved by crystallization.
Fumitoshi Yagishita, Norifumi Kamataki, Kazuma Okamoto, Shota Kanno, Takashi Mino, Hyuma Masu, Masami Sakamoto   +6 more
doaj   +1 more source

TLR7 Agonist GS–9620 Combined with Nicotinamide Generate Viral Reactivation in Seronegative SHIV_SF162P3-Infected Rhesus Monkeys

Biomedicines, 2023
Antiretroviral therapy is capable of inhibiting HIV replication, but it fails to completely achieve a cure due to HIV persistence. The commonly used HIV cure approach is the “shock and kill” strategy, which employs latency-reversing agents to trigger ...
Zhe Cong, Yuting Sun, Cui Dang, Chenbo Yang, Jingjing Zhang, Jiahan Lu, Ting Chen, Qiang Wei, Wei Wang, Jing Xue   +9 more
doaj   +1 more source

Rhoifolin Alleviates Ulcerative Colitis by Targeting NMNAT1 and Activating SIRT1-FOXO1 Signaling to Enhance ILC3s Effector Function. [PDF]

Adv Sci (Weinh)
Rhoifolin directly targets NMNAT1, thereby activating nicotinamide salvage pathway and promoting intracellular NAD+ biosynthesis. Elevated NAD+ levels enhance SIRT1 activity, leading to FOXO1 deacetylation and nuclear translocation. Nuclear FOXO1 subsequently binds to the IL‐22 promoter, upregulating IL‐22 transcription and potentiating ILC3 effector ...
Yang H, Zhang Y, Feng S, Ma X, Feng J, Wang J, Gao J, Pan A, Wu D, Ding K, Zheng C, Lv Q, Hu L.   +12 more
europepmc   +2 more sources

Nicotinamide

Reactions Weekly
Abstract Nicotinamide (vitamin B3, Niacinamide) is a water-soluble NAD⁺/NADP⁺ precursor central to epidermal energy metabolism and cutaneous homeostasis. As an ingestible nutricosmetic, a 10 mg/day dose (~66% U.S. DV) provides a functionally active yet well-tolerated intake that supports multiple skin targets.
  +6 more sources

Effect of combined nicotinamide, acetyl-L-carnitine and α-lipoic acid action on separate links of carbohydrate metabolism under experimental type 2 diabetes

Біологічні студії, 2014
The effect of nicotinamide, acetyl-L-carnitine and α-lipoic acid on the separate links of carbohydrate metabolism in the brain, heart and liver of rats for type 2 diabetes it was investigated.
Iu. T. Sergiichuk, T. M. Tykhonenko, M. M. Guzyk, L. V. Yanitska, T. M. Kuchmerovska   +4 more
doaj   +1 more source

Study of antidiabetic activity of two novel Schiff base derived dibromo and dichloro substituted compounds in streptozotocin-nicotinamide-induced diabetic rats: pilot study

, 2023
Schiff bases are aldehyde-or ketone-like chemical compounds in which an imine or azomethine group replaces the carbonyl group. Such compounds show various beneficial biological activities, such as anti-inflammation and antioxidants.
Sima Kianpour Rad (16524754), Nazia Binti Abdul Majid (16524757), Kamelia Saremi (16524751), Zohreh Shahnavaz (3765415)   +3 more
core   +1 more source

Effect of Solvent Polarity on the Absorption and Fluorescence Spectra of Nicotinamide: Determination of Ground and Excited State Dipole Moments

East European Journal of Physics, 2022
Nicotinamide (NIC) is an amide-form vitamin with a carboxamide group at b positions that is involved in a variety of biological activities. The drugs contain functional groups which control the type and degree of interaction with different solvents.
Ataklti Abraha Gebreyohanes, Abebe Belay, Getachew Alemu   +2 more
doaj   +1 more source

Pyridine nucleotide synthesis by rat adipose tissue in vitro

Journal of Lipid Research, 1967
The synthesis of NAD and NADP by rat adipose tissue was measured in vitro. Nicotinamide-7-14C and NaH232PO4 were incorporated together into NAD with a 32P/14C ratio of 1.82 and nicotinic-7-14C acid and NaH232PO4 with a ratio of 1.94.
Richard W. Hanson, Zigmund Z. Ziporin
doaj   +1 more source

Arsenic Trioxide, Itraconazole, All-Trans Retinoic Acid and Nicotinamide: A Proof of Concept for Combined Treatments with Hedgehog Inhibitors in Advanced Basal Cell Carcinoma

Biomedicines, 2020
The treatment of advanced basal cell carcinoma has seen a progressive evolution in recent years following the introduction of Hedgehog pathway inhibitors.
Terenzio Cosio, Monia Di Prete, Elena Campione   +2 more
doaj   +1 more source

Patients’ willingness to accept adverse event and cost tradeoffs from oral nicotinamide for reduced risk of non-melanoma skin cancer

Journal of Dermatological Treatment, 2023
Background Non-immunosuppressed patients with a history of multiple non-melanoma skin cancers (NMSCs) taking oral nicotinamide supplementation experienced a 23% decrease in annual NMSC risk in a randomized clinical trial.
Marco Boeri, Maral K. Skelsey, James A. Schiro, Susan E. Dozier, Robert Glinert, Martin M. Okun   +5 more
doaj   +1 more source