Results 21 to 30 of about 222,121 (295)

Discovery of New VEGFR-2 Inhibitors: Design, Synthesis, Anti-Proliferative Evaluation, Docking, and MD Simulation Studies

open access: yesMolecules, 2022
Four new nicotinamide-based derivatives were designed as antiangiogenic VEGFR-2 inhibitors. The congeners were synthesized possessing the pharmacophoric essential features to bind correctly with the VEGFR-2 active pocket.
Eslam B. Elkaeed   +10 more
doaj   +1 more source

Effects of Succinate-Based Antioxidant on in vitro Conversion of Methemoglobin in Oxyhemoglobin

open access: yesОбщая реаниматология, 2018
The purpose of the study — to determine the feasibility of using the succinate-based antioxidant for the in vitro reduction of excessive methemoglobin to oxyhemoglobin in blood.Materials and Methods. Blood sampling was performed in five healthy donors in
A. M. Chernysh   +6 more
doaj   +1 more source

Mathematical modelling of diurnal regulation of carbohydrate allocation by osmo-related processes in plants [PDF]

open access: yes, 2015
Copyright & Usage © 2015 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are ...
Ebenhöh, Oliver, Pokhilko, Alexandra
core   +1 more source

Synthesis, characterization, and antibacterial activity of anion-depended Cu(II)-Niacinamide complexes

open access: yesKuwait Journal of Science, 2023
This study aims to prepare different types of Cu(II)-niacinamide complexes by layered solution method from various source of Cu(II) salts (sulphate, nitrate, chloride, and acetate) and in various M(II):niacinamide molar ratio (1:2, 1:4, and 1:6).
Nadia Cikita Handayani   +4 more
doaj   +1 more source

Synthesis, crystal structure and Hirshfeld surface analysis of a 1D coordination polymer catena-poly[[diaquabis(nicotinamide-κN1)nickel(II)]-μ-fumarato-κ2O1:O4]

open access: yesActa Crystallographica Section E: Crystallographic Communications, 2018
The reaction of NiCl2 with fumaric acid and nicotinamide in basic solution produces the title polymeric complex, [Ni(C4H2O4)(C6H6N2O)2(H2O)2]n. The NiII cation, located on an inversion centre, is coordinated by two O atoms of the fumarate dianions, two N
Sevgi Kansiz   +2 more
doaj   +1 more source

Novel Inhibitors of Nicotinamide-N-Methyltransferase for the Treatment of Metabolic Disorders

open access: yesMolecules, 2021
Nicotinamide-N-methyltransferase (NNMT) is a cytosolic enzyme catalyzing the transfer of a methyl group from S-adenosyl-methionine (SAM) to nicotinamide (Nam). It is expressed in many tissues including the liver, adipose tissue, and skeletal muscle.
Aimo Kannt   +9 more
doaj   +1 more source

Whole blood NAD and NADP concentrations are not depressed in subjects with clinical pellagra [PDF]

open access: yes, 2007
Population surveys for niacin deficiency are normally based on clinical signs or on biochemical measurements of urinary niacin metabolites. Status may also be determined by measurement of whole blood NAD and NADP concentrations. To compare these methods,
Cheung, E   +5 more
core   +2 more sources

Comparative analysis of the pharmacokinetic parameters of transdermal and injectable forms of nicotinamide

open access: yesВестник трансплантологии и искусственных органов, 2023
In recent years, oxidative stress, characterized by excess free radicals in the body, has been called the cause of many diseases. There is an active search for drugs with antioxidant properties that are suitable for long-term maintenance therapy ...
V. A. Ryzhikova   +6 more
doaj   +1 more source

Performance Assessment of UVAPS: Influence of Fungal Spore Age and Air Exposure [PDF]

open access: yes, 2007
This work focused on two main outcomes. The first was the assessment of the response of the Ultraviolet Aerodynamic Particle Sizer Spectrometer (UVAPS) for two different fungal spore species.
Agranovski   +36 more
core   +2 more sources

Meta-analytical evaluation of the clinical efficacy of a complex metabolic neuroprotector in patients with chronic cerebral ischemia

open access: yesАнтибиотики и Химиотерапия, 2022
The aim of the study is to evaluate the clinical efficacy, safety, and impact of the complex metabolic neuroprotector on the patients’ quality of life (CMN) Cytoflavin in tablets, as well as in the course of stepwise pharmacotherapy of patients with ...
M. V. Zhuravleva   +5 more
doaj   +1 more source

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