Results 21 to 30 of about 126,234 (257)

Arsenic Trioxide, Itraconazole, All-Trans Retinoic Acid and Nicotinamide: A Proof of Concept for Combined Treatments with Hedgehog Inhibitors in Advanced Basal Cell Carcinoma

Biomedicines, 2020
The treatment of advanced basal cell carcinoma has seen a progressive evolution in recent years following the introduction of Hedgehog pathway inhibitors.
Terenzio Cosio, Monia Di Prete, Elena Campione   +2 more
doaj   +1 more source

Patients’ willingness to accept adverse event and cost tradeoffs from oral nicotinamide for reduced risk of non-melanoma skin cancer

Journal of Dermatological Treatment, 2023
Background Non-immunosuppressed patients with a history of multiple non-melanoma skin cancers (NMSCs) taking oral nicotinamide supplementation experienced a 23% decrease in annual NMSC risk in a randomized clinical trial.
Marco Boeri, Maral K. Skelsey, James A. Schiro, Susan E. Dozier, Robert Glinert, Martin M. Okun   +5 more
doaj   +1 more source

5-Trifluoromethoxy-substituted Nicotinic Acid, Nicotinamide and Related Compounds

Журнал органічної та фармацевтичної хімії
A practical and convenient method for synthesizing nicotinic acid and nicotinamide with the trifluoromethoxy group in position 5 of the ring has been developed.
Taras M. Sokolenko, Yurii L. Yagupolskii
doaj   +1 more source

Nicotinamide prevention in diabetes-induced alterations in the rat liver

Endocrine Regulations, 2023
Objective. The study was performed to elucidate whether nicotinamide (NAm) can attenuate the diabetes-induced liver damage by correction of ammonia detoxifying function and disbalance of NAD-dependent processes in diabetic rats.
Kuchmerovska Tamara, Yanitska Lesya, Horkunenko Oksana, Guzyk Mykhailo, Tykhonenko Tetiana, Pryvrotska Irina   +5 more
doaj   +1 more source

N-methyl-2-pyridone-5-carboxamide (2PY)—Major Metabolite of Nicotinamide: An Update on an Old Uremic Toxin

Toxins, 2016
N-methyl-2-pyridone-5-carboxamide (2PY, a major metabolite of nicotinamide, NAM) was recently identified as a uremic toxin. Recent interventional trials using NAM to treat high levels of phosphorus in end-stage renal disease have highlighted new ...
Aurélie Lenglet, Sophie Liabeuf, Sandra Bodeau, Loïc Louvet, Aurélien Mary, Agnès Boullier, Anne Sophie Lemaire-Hurtel, Alexia Jonet, Pascal Sonnet, Said Kamel, Ziad A. Massy   +10 more
doaj   +1 more source

Biosynthesis of squalene and cholesterol by cell-free extracts of adult rat brain

Journal of Lipid Research, 1969
Cell-free extracts of adult rat brain incubated with mevalonic acid-2-14C synthesize 14C-labeled nonsaponifiable fractions consisting largely of squalene-14C.
M.T. Kelley, R.T. Aexel, B.L. Herndon, H.J. Nicholas   +3 more
doaj   +1 more source

Chitin Nanofibril-Nanolignin Complexes as Carriers of Functional Molecules for Skin Contact Applications

Nanomaterials, 2022
Chitin nanofibrils (CN) and nanolignin (NL) were used to embed active molecules, such as vitamin E, sodium ascorbyl phosphate, lutein, nicotinamide and glycyrrhetinic acid (derived from licorice), in the design of antimicrobial, anti-inflammatory and ...
Maria-Beatrice Coltelli, Pierfrancesco Morganti, Valter Castelvetro, Andrea Lazzeri, Serena Danti, Bouchra Benjelloun-Mlayah, Alessandro Gagliardini, Alessandra Fusco, Giovanna Donnarumma   +8 more
doaj   +1 more source

Nicotinamide Content of Insects [PDF]

Australian Journal of Biological Sciences, 1965
Surprisingly little is known of the vitamin content of insects and consequently, as part of an investigation of the function and metabolism of insect tissues, we have determined the nicotinamide content of a wide range of adult insects collected locally in the Wellington district.
G B, Kitto, M H, Briggs
openaire   +2 more sources

Nicotinamide Supplementation Improves Oocyte Quality and Offspring Development by Modulating Mitochondrial Function in an Aged Caenorhabditis elegans Model

Antioxidants, 2021
Aging is associated with a decline in the quality of biological functions. Among the aging processes, reproductive aging is a critical process because of its intergenerational effects.
Hyemin Min, Mijin Lee, Kyoung Sang Cho, Hyunjung Jade Lim, Yhong-Hee Shim   +4 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source