Results 21 to 30 of about 159,186 (304)

Pharmacokinetics of the SABRE agent 4,6-d2-Nicotinamide and also Nicotinamide in rats following oral and intravenous administration [PDF]

, 2019
To prepare the way for using the isotopically labelled SABRE hyperpolarised 4,6-d2-nicotinamide as an MRI agent in humans we have performed an in-vivo study to measure its pharmacokinetics in the plasma of healthy rats after intravenous and oral ...
Cheetham, Graham Mark Thomas, Linnik, Inna, Rayner, Peter John, Stow, Ruth, Duckett, Simon   +4 more
core   +1 more source

The Influence of Nicotinamide on Health and Disease in the Central Nervous System [PDF]

, 2018
Nicotinamide, the amide form of vitamin B3 (niacin), has long been associated with neuronal development, survival, and function in the central nervous system (CNS), being implicated in both neuronal death and neuroprotection. Here, we summarise a body of
Fricker, R, Green, E, Griffin, S, Jenkins, S   +3 more
core   +1 more source

Effect of combined nicotinamide, acetyl-L-carnitine and α-lipoic acid action on separate links of carbohydrate metabolism under experimental type 2 diabetes

Біологічні студії, 2014
The effect of nicotinamide, acetyl-L-carnitine and α-lipoic acid on the separate links of carbohydrate metabolism in the brain, heart and liver of rats for type 2 diabetes it was investigated.
Iu. T. Sergiichuk, T. M. Tykhonenko, M. M. Guzyk, L. V. Yanitska, T. M. Kuchmerovska   +4 more
doaj   +1 more source

Nicotinamide promotes neuronal differentiation of mouse embryonic stem cells in vitro

, 2013
Factors controlling proliferation and differentiation are crucial in advancement of neural cell-based experimental neurodegenerative therapies. In this regard, nicotinamide has been shown to determine the fate of neural cells, enhance neuralization, and ...
Griffin, SM, Fricker, RA, Orme, RP, Pickard, MR, Hawkins, CP   +4 more
core   +2 more sources

Effect of Solvent Polarity on the Absorption and Fluorescence Spectra of Nicotinamide: Determination of Ground and Excited State Dipole Moments

East European Journal of Physics, 2022
Nicotinamide (NIC) is an amide-form vitamin with a carboxamide group at b positions that is involved in a variety of biological activities. The drugs contain functional groups which control the type and degree of interaction with different solvents.
Ataklti Abraha Gebreyohanes, Abebe Belay, Getachew Alemu   +2 more
doaj   +1 more source

Nicotinamide and demographic and disease transitions:moderation is best [PDF]

, 2019
Good health and rapid progress depend on an optimal dose of nicotinamide. Too little meat triggers the neurodegenerative condition pellagra and tolerance of symbionts such as tuberculosis (TB), risking dysbioses and impaired resistance to acute ...
Hill, Lisa J; id_orcid, Williams, Adrian C   +1 more
core   +1 more source

Pyridine nucleotide synthesis by rat adipose tissue in vitro

Journal of Lipid Research, 1967
The synthesis of NAD and NADP by rat adipose tissue was measured in vitro. Nicotinamide-7-14C and NaH232PO4 were incorporated together into NAD with a 32P/14C ratio of 1.82 and nicotinic-7-14C acid and NaH232PO4 with a ratio of 1.94.
Richard W. Hanson, Zigmund Z. Ziporin
doaj   +1 more source

Arsenic Trioxide, Itraconazole, All-Trans Retinoic Acid and Nicotinamide: A Proof of Concept for Combined Treatments with Hedgehog Inhibitors in Advanced Basal Cell Carcinoma

Biomedicines, 2020
The treatment of advanced basal cell carcinoma has seen a progressive evolution in recent years following the introduction of Hedgehog pathway inhibitors.
Terenzio Cosio, Monia Di Prete, Elena Campione   +2 more
doaj   +1 more source

Patients’ willingness to accept adverse event and cost tradeoffs from oral nicotinamide for reduced risk of non-melanoma skin cancer

Journal of Dermatological Treatment, 2023
Background Non-immunosuppressed patients with a history of multiple non-melanoma skin cancers (NMSCs) taking oral nicotinamide supplementation experienced a 23% decrease in annual NMSC risk in a randomized clinical trial.
Marco Boeri, Maral K. Skelsey, James A. Schiro, Susan E. Dozier, Robert Glinert, Martin M. Okun   +5 more
doaj   +1 more source

5-Trifluoromethoxy-substituted Nicotinic Acid, Nicotinamide and Related Compounds

Журнал органічної та фармацевтичної хімії
A practical and convenient method for synthesizing nicotinic acid and nicotinamide with the trifluoromethoxy group in position 5 of the ring has been developed.
Taras M. Sokolenko, Yurii L. Yagupolskii
doaj   +1 more source