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Nicotinamide adenine dinucleotide (oxidized form, NAD+) serves as a co-substrate and co-enzyme in cells to execute its key roles in cell signalling pathways and energetic metabolism, arbitrating cell survival and death. It was discovered in 1906 by Arthur Harden and William John Young in yeast extract which could accelerate alcohol fermentation.
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NAD + Metabolism in Cardiac Health, Aging, and Disease
Circulation, 2021Mahmoud Abdellatif +2 more
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Regulation of NAD+ metabolism in aging and disease
Metabolism: Clinical and Experimental, 2022Xiaogang Chu, Raghavan Raju
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NAD+ metabolism and its roles in cellular processes during ageing
Nature Reviews Molecular Cell Biology, 2020Anthony J Covarrubias +2 more
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NAD+ Metabolism Maintains Inducible PD-L1 Expression to Drive Tumor Immune Evasion
Cell Metabolism, 2021Dan Ye, Yufei He, Hongyang Wang
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NAD + homeostasis in human health and disease
EMBO Molecular Medicine, 2021Ruben Zapata-Pérez +2 more
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