Exploring the Determinants Impacting Work-Life Balance for General Nurses in Diverse Healthcare Settings: A Cross-Sectional Study. [PDF]
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Targeting iNAMPT and NAD Biosynthesis to Break the Obesity-Associated Liver Cancer Link. [PDF]
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Oxygen vacancy-engineered bimetallic nanozymes for disrupting electron transport chain and synergistic multi-enzyme activity to reverse oxaliplatin resistance in colorectal cancer. [PDF]
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Redirecting Intermediary Metabolism to Counteract Cyanide Poisoning. [PDF]
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Targeting Dio3 to enhance mitophagy and ameliorate skeletal muscle wasting in sepsis. [PDF]
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Nicotinic acid riboside maintains NAD<sup>+</sup> homeostasis and ameliorates aging-associated NAD<sup>+</sup> decline. [PDF]
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NAD+ and cardiovascular diseases
Clinica Chimica Acta, 2021Nicotinamide adenine dinucleotide (NAD) plays pivotal roles in controlling many biochemical processes. 'NAD' refers to the chemical backbone irrespective of charge, whereas 'NAD+' and 'NADH' refers to oxidized and reduced forms, respectively. NAD+/NADH ratio is essential for maintaining cellular reduction-oxidation (redox) homeostasis and for ...
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NAD+-pyridoxine and NAD+-pyridoxamine complexes
Biochimica et Biophysica Acta (BBA) - General Subjects, 1971Abstract 1. 1. NAD+-pyridoxamine complexes were studied by fluorescence techniques at 30° over a pH range of 8.4–10.0. 2. 2. The polarization factor was seen to increase with increasing NAD+ concentration in all cases. 3. 3. Fluorescence quenching studis established large complex formation constants for both complexes. 4. 4.
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Evidence for binding of NAD dimers to NAD-dependent dehydrogenases
Biochimica et Biophysica Acta (BBA) - Enzymology, 1981The binding of dimers of nicotinamide adenine dinucleotide, (NAD)2, to lactate, malate and alcohol dehydrogenase has been studied by the fluorescence quenching technique. While the alcohol dehydrogenase shows a low binding ability, malate and lactate dehydrogenases have been found to bind (NAD)2 in a specific way with high affinity.
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