Therapeutic targeting of chromatin alterations in leukemia and solid tumors
International Journal of Cancer, EarlyView.Abstract Alterations in chromatin conformation and post‐translational modification of histones have become increasingly recognized as critical drivers of cancer development, progression, and therapy resistance. Recent advances in drug development have led to the establishment of several highly selective small molecule inhibitors, several of which are ...
Florian Perner +7 more
wiley +1 more source
The effect of the NADPH oxidase inhibitor diphenyleneiodonium on aerobic and anaerobic microbicidal activities of human neutrophils [PDF]
, 1988 Juliet A. Ellis +2 more
openalex +1 more source
Molecular Plant, 2013 Stimulus-specific accumulation of second messengers like reactive oxygen species (ROS) and Ca(2+) are central to many signaling and regulation processes in plants.
Maria M Drerup +6 more
semanticscholar +1 more source
Hyperactivation of B cells from Immunodeficient Patients [PDF]
, 2013 poster abstractChronic granulomatous disease (CGD) is an inherited immunodeficiency associated with defects in NADPH oxidase, an enzyme that produces oxygen radicals necessary to kill bacterial and fungal pathogens.
Deffit, Sarah N. +2 more
core
Illuminating Immunity: A Systematic Review of Immune Cell Autofluorescence
Journal of Biophotonics, EarlyView.ABSTRACT Immunophenotyping provides valuable prognostic and diagnostic information, but is technically complex and expensive. The assessment of autofluorescence is label‐free and provides complex information on cell identity. However, research on its application to immunophenotyping has been heterogenous.
Aline Knab +4 more
wiley +1 more source
Disease Models & Mechanisms, 2015 Activity of the oxidative phosphorylation system (OXPHOS) is decreased in humans and mice with nonalcoholic steatohepatitis. Nitro-oxidative stress seems to be involved in its pathogenesis.
Inmaculada García-Ruiz +4 more
doaj +1 more source
Glucose oxidase immobilization onto carbon nanotube networking [PDF]
Ukrainian Journal of Physics, Vol. 57, No. 7, 2012, pp. 700-709, 2012 When elaborating the biosensor based on single-walled carbon nanotubes (SWNTs), it is necessary to solve such an important problem as the immobilization of a target biomolecule on the nanotube surface. In this work, the enzyme (glucose oxidase (GOX)) was immobilized on the surface of a nanotube network, which was created by the deposition of nanotubes ...
arxiv
Role of NADPH Oxidase-Mediated Reactive Oxygen Species in Podocyte Injury
BioMed Research International, 2013 Proteinuria is an independent risk factor for end-stage renal disease (ESRD) (Shankland, 2006). Recent studies highlighted the mechanisms of podocyte injury and implications for potential treatment strategies in proteinuric kidney diseases (Zhang et al.,
Shanshan Chen, Xianfang Meng, Chun Zhang
semanticscholar +1 more source
Macrophage and Preeclampsia: Macrophage Polarization Imbalance at the Maternal‐Fetal Interface
Journal of Clinical Laboratory Analysis, EarlyView.The development and progression of preeclampsia (PE) are associated with immune‐inflammatory responses induced by placental dysfunction. The polarization imbalance of decidual macrophages, particularly the increase in M1 polarization, exacerbates placental inflammation.
Yao Wei +6 more
wiley +1 more source
Superoxide production by polymorphonuclear leucocytes in rheumatoid arthritis and osteoarthritis: in vivo inhibition by the antirheumatic drug piroxicam due to interference with the activation of the NADPH-oxidase. [PDF]
, 1986 P Biemond +4 more
openalex +1 more source