Results 191 to 200 of about 95,385 (310)

Prenatal modulation of NADPH-oxidase reverses the deranged GABA switch and rescues behavioral deficits in valproate ASD rat model. [PDF]

open access: yesFront Pharmacol
Yasseen BA   +19 more
europepmc   +1 more source

Therapeutic potential of hesperidin in diabetes mellitus‐induced erectile dysfunction through Nrf2‐mediated ferroptosis and oxidative stress

open access: yesAndrology, EarlyView.
Abstract Background Among erectile dysfunction (ED) caused by metabolic abnormalities, diabetes mellitus‐induced ED (DMED) progresses rapidly, manifests with severe symptoms, and shows reduced responsiveness to conventional medications. Hyperglycemia in the corpus cavernosum has been linked to the induction of both ferroptosis and oxidative stress ...
Sheng Xin   +8 more
wiley   +1 more source

Relaxin‐2 improves type I diabetes mellitus‐induced erectile dysfunction in rats by protecting cavernous endothelial and smooth muscle function, and inhibiting penile fibrosis and apoptosis

open access: yesAndrology, EarlyView.
Abstract Background Diabetes mellitus‐induced erectile dysfunction (DMED) responds poorly to first‐line treatments, necessitating the development of new therapeutic strategies. Relaxin‐2 (RLX‐2) plays a crucial role in protecting vascular endothelium, vasodilatation, and antifibrosis in various diseases.
Bocheng Tu   +10 more
wiley   +1 more source

Molecular and cellular mechanisms underlying gyrate atrophy: Why is the retina primarily affected?

open access: yesActa Ophthalmologica, EarlyView.
Abstract Gyrate atrophy of the choroid and retina (GACR; OMIM #258870) is a rare early‐onset autosomal recessive disorder, caused by bi‐allelic pathogenic variants in the gene coding for ornithine aminotransferase (OAT) resulting in hyperornithinaemia.
Mark J. N. Buijs   +12 more
wiley   +1 more source

A Natural Inhibitor, 1'<i>S</i>-1'-Acetoxychavicol Acetate, Against Testosterone-Induced Alopecia via NADPH Oxidase Regulation. [PDF]

open access: yesMolecules
Park K   +11 more
europepmc   +1 more source

Diagnostics of Autoimmune Hepatitis Enabled by Non‐Invasive Clinical Proteomics

open access: yesAlimentary Pharmacology &Therapeutics, EarlyView.
Mass‐spectrometry‐based proteomic analyses of paired liver‐plasma samples from patients with AIH enabled discovery of numerous proteins showing high diagnostic accuracy. Proteomics may constitute a novel non‐invasive diagnostic tool for AIH if validated in larger, age‐ and sex‐matched cohorts.
Anne‐Sofie Houlberg Jensen   +20 more
wiley   +1 more source

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