Results 211 to 220 of about 95,385 (310)

Mechanisms Involved in Focal Adhesion Signaling Regulating Tumor Anoikis Resistance

Cancer Science, EarlyView.
ABSTRACT Among the numerous malignant behaviors of tumors, metastasis plays a critical role in contributing to poor prognosis. Anoikis is a distinct form of apoptosis induced when cells detach from the extracellular matrix (ECM) or adhere to an improper ECM. It is a physiological obstacle to tumor cell metastasis. Anoikis resistance is considered to be
Bin Liu, Qingqing Wu, Zuodong Xuan, Zeyuan Zheng, Yifan Du, Xiuyuan Sui, Haodong Wu, Zeyi Zhang, Zhengying Zhang, Min Zhong, Yue Zhao, Huimin Sun, Chen Shao   +12 more
wiley   +1 more source

NADPH Oxidase 4: Crucial for Endothelial Function under Hypoxia-Complementing Prostacyclin. [PDF]

Antioxidants (Basel)
Brendel H, Mittag J, Hofmann A, Hempel H, Giebe S, Diaba-Nuhoho P, Wolk S, Reeps C, Morawietz H, Brunssen C.   +9 more
europepmc   +1 more source

cGAS–STING Pathway Activation Enhances Antitumor Effect of Talaporfin Photodynamic Therapy Through ROS Production

Cancer Science, EarlyView.
This study investigates the role of STING in photodynamic therapy (PDT) using talaporfin sodium. STING knockout reduced ROS generation and therapeutic efficacy, while combining a STING agonist with PDT enhanced antitumor effects. These findings suggest that STING regulates ROS homeostasis and can potentiate PDT outcomes.
Makiko Sasaki, Mamoru Tanaka, Yasunari Sasaki, Yuki Kojima, Taketo Suzuki, Hirotada Nishie, Shigeki Fukusada, Naomi Sugimura, Keiji Ozeki, Takaya Shimura, Eiji Kubota, Hiromi Kataoka   +11 more
wiley   +1 more source

Impact of Hospitalization on Sarcopenia, NADPH-Oxidase 2, Oxidative Stress, and Low-Grade Endotoxemia in Elderly Patients. [PDF]

Antioxidants (Basel)
Bagnato C, Magna A, Mereu E, Bernardini S, Bartimoccia S, Marti R, Lazzerini PE, D'Amico A, Ettorre E, Desideri G, Pignatelli P, Violi F, Carnevale R, Loffredo L, Neurodegenerative Study Group.   +14 more
europepmc   +1 more source

NADPH oxidase of neutrophils: mode of association between the third cytosolic component, p40, with p67.

, 1996
Shigenori Kagara, Shohko Tsunawaki
openalex   +2 more sources

MFG‐E8 Accelerates Abdominal Aortic Aneurysm Formation by Enhancing ERK MAPK/NOX4 Axis‐Associated Oxidative Stress

Cell Proliferation, EarlyView.
MFG‐E8 promotes oxidative stress by upregulating NOX4 and activating the MAPK pathway, which increases ROS production and affects vascular smooth muscle cell (VSMC) apoptosis, thereby driving the progression of abdominal aortic aneurysm (AAA). Resveratrol can inhibit the expression and function of MFG‐E8, reduce ROS generation, and lower the incidence ...
Jie Xiao, Hai Hu, Minghui Zou, Chenhao Li, Dawei Deng, Xing Chen, Jinping Liu   +6 more
wiley   +1 more source

Salicylate plant defences reduce aphid nutritional quality and increase predator consumption

Ecological Entomology, EarlyView.
Salicylic acid‐induced defences diminish Macrosiphum euphorbiae performance and nutritional quality by reducing body protein and lipid content. Ladybird beetle predators (Hippodamia convergens) consumed more low‐quality aphids compared to high‐quality aphids, exhibiting compensatory feeding response to nutrient‐deficient p prey.
Bijay Subedi, Victoria Marie Pocius, Mary Arlin Bunnell, Abigail Myers, Mônica F. Kersch‐Becker   +4 more
wiley   +1 more source

Interplay between energy metabolism and NADPH oxidase-mediated pathophysiology in cardiovascular diseases. [PDF]

Front Pharmacol
Jie H, Zhang J, Wu S, Yu L, Li S, Dong B, Yan F.   +6 more
europepmc   +1 more source

Studies of the membrane‐bound flavocytochrome MsrQ flavin mononucleotide (FMN)‐binding site reveal an unexpected ubiquinone cofactor

The FEBS Journal, EarlyView.
The membrane‐bound heme flavoprotein MsrQ is the specific electron donor for the periplasmic methionine sulfoxide reductase MsrP. Analysis of its flavin environment revealed that ubiquinone (UQ) is a cofactor for MsrQ. However, redox studies demonstrate that UQ cannot function as an electron donor for the MsrPQ system.
Philippe Carpentier, Fabien Pierrel, Nicolas Duraffourg, Bruno Guigliarelli, Mahmoud Hajj Chehade, Laura Flandrin, Christian Basset, Christelle Caux, Stéphane Torelli, Vincent Nivière   +9 more
wiley   +1 more source

Resveratrol attenuates the priapism phenotype in sickle cell mice by restoring NO-cGMP-PDE5 signaling and reducing NADPH oxidase 2 expression. [PDF]

Front Pharmacol
Splendore CO, Silveira THR, Pereira DA, Bossarino BP, de Oliveira MG, Calmasini FB, Burnett AL, Costa FF, Silva FH.   +8 more
europepmc   +1 more source