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Phagocyte NADPH oxidase and specific immunity
Clinical Science, 2015The phagocyte NADPH oxidase NOX2 produces reactive oxygen species (ROS) and is a well-known player in host defence. However, there is also increasing evidence for a regulatory role of NOX2 in adaptive immunity. Deficiency in phagocyte NADPH oxidase causes chronic granulomatous disease (CGD) in humans, a condition that can also be studied in CGD mice ...
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The NADPH‐Dependent Oxidase of Phagocytes
Proceedings of the Association of American Physicians, 1999Polymorphonuclear leukocytes (PMNs) represent a prominent cellular element in the innate immune system, serving to ingest exogenous particles and microbes and to kill phagocytosed microorganisms. The microbicidal activity of PMNs depends on the interactions of a broad array of potent systems, including relatively stable degradative proteins as well as ...
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The activation of the electrogenic NADPH oxidase [PDF]
Biochemical Society Transactions, 1991 Lydia M. Henderson, J. B. Chappell
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NADPH oxidases and oxidase crosstalk in cardiovascular diseases: novel therapeutic targets
Nature Reviews Cardiology, 2020Yixuan Zhang, Hua Cai
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Reactive oxygen species (ROS) as pleiotropic physiological signalling agents
Nature Reviews Molecular Cell Biology, 2020Helmut Sies, Dean P Jones
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Cellular mechanisms and physiological consequences of redox-dependent signalling
Nature Reviews Molecular Cell Biology, 2014Kira M Holmström, Toren Finkel
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