Results 341 to 350 of about 424,484 (404)

Complex non‐Markovian dynamics and the dual role of astrocytes in Alzheimer’s disease development and propagation

open access: yesQuantitative Biology, Volume 13, Issue 3, September 2025.
Abstract Alzheimer’s disease (AD) is a common neurodegenerative disorder nowadays. Amyloid‐beta (Aβ) and tau proteins are among the main contributors to the AD progression. In AD, Aβ proteins clump together to form plaques and disrupt cell functions.
Swadesh Pal, Roderick Melnik
wiley   +1 more source

Angiotensin II Type 1 Receptor Blocker Usage Prevents Oxidative Stress and Muscle Dysfunction in HIV

open access: yesFundamental &Clinical Pharmacology, Volume 39, Issue 4, August 2025.
ABSTRACT Background We aimed to elucidate the role of Angiotensin II type 1 receptor (AT1R) blocker usage in muscle wasting and dysfunction related to HIV. Research Design and Methods Appendicular skeletal muscle mass, higher and lower limb strength, and physical fitness were determined in people living with HIV (PWH) using AT1R blockers users (n = 33),
Rafael Deminice   +4 more
wiley   +1 more source

Inflammation and response to bacterial infection as potential drivers of equine odontoclastic tooth resorption and hypercementosis: A proteomics insight

open access: yesEquine Veterinary Journal, Volume 57, Issue 4, Page 977-990, July 2025.
Abstract Background Equine dental diseases significantly impact a horse's overall health, performance and quality of life. They can result in secondary infections and digestive disturbances, potentially leading to colic. A recently described disease affecting the incisors of horses is equine odontoclastic tooth resorption and hypercementosis (EOTRH ...
Anders Jensen   +9 more
wiley   +1 more source

Melatonin: A Potential Therapy for Osteoporosis With Insights Into Molecular Mechanisms

open access: yesJournal of Pineal Research, Volume 77, Issue 4, July 2025.
ABSTRACT Melatonin is a versatile neurohormone with diverse molecular functions, including sleep regulation, inflammation reduction, antioxidant activity, immune modulation, and anticancer properties. In bone metabolism, it promotes osteoblast formation, inhibits osteoclast activity, and synchronizes skeletal tissue rhythms to support bone health.
Ko‐Hsiu Lu   +4 more
wiley   +1 more source

The Gut Microbial Metabolite Butyrate Alleviates IL‐1β‐Induced Mitochondrial Dysfunction and Oxidative Stress in Pancreatic Islets

open access: yesThe FASEB Journal, Volume 39, Issue 11, 15 June 2025.
Butyrate, a gut microbiota‐derived metabolite, protects pancreatic beta cells from interleukin‐1beta (IL‐1β)‐induced dysfunction. In a model of low‐grade inflammation using long‐term, non‐cytotoxic IL‐1β stimulation, butyrate enhanced mitochondrial function, promoted hyperfusion, and reduced mitochondrial fragmentation in mouse pancreatic islets ...
Signe Schultz Pedersen   +6 more
wiley   +1 more source

Home - About - Disclaimer - Privacy