Results 381 to 390 of about 424,484 (404)
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Analytical Biochemistry, 1997
The enzymatic determination of hydrogen peroxide can be accomplished with high sensitivity and specificity using N-acetyl-3, 7-dihydroxyphenoxazine (Amplex Red), a highly sensitive and chemically stable fluorogenic probe for the enzymatic determination ...
Mingjie Zhou +3 more
semanticscholar +1 more source
The enzymatic determination of hydrogen peroxide can be accomplished with high sensitivity and specificity using N-acetyl-3, 7-dihydroxyphenoxazine (Amplex Red), a highly sensitive and chemically stable fluorogenic probe for the enzymatic determination ...
Mingjie Zhou +3 more
semanticscholar +1 more source
NADPH oxidases in cardiovascular disease
Free Radical Biology and Medicine, 2010Reactive oxygen species (ROS) contribute to several aspects of vascular diseases including ischemia-reperfusion injury, scavenging of nitric oxide, or stimulation of inflammation and hypertrophy. NADPH oxidases of the Nox family are differentially expressed in the cardiovascular system, induced or activated by cardiovascular risk factors and ...
Norbert Weissmann +2 more
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Assembly of the phagocyte NADPH oxidase
Histochemistry and Cell Biology, 2004Stimulated phagocytes undergo a burst in respiration whereby molecular oxygen is converted to superoxide anion through the action of an NADPH-dependent oxidase. The multicomponent phagocyte oxidase is unassembled and inactive in resting cells but assembles at the plasma or phagosomal membrane upon phagocyte activation.
William M. Nauseef, William M. Nauseef
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Receptor Activation of NADPH Oxidases
Antioxidants & Redox Signaling, 2010Reactive oxygen species (ROS) have been implicated in many intra- and intercellular processes. High levels of ROS are generated as part of the innate immunity in the respiratory burst of phagocytic cells. Low levels of ROS, however, are generated in a highly controlled manner by various cell types to act as second messengers in redox-sensitive pathways.
Michael Weitnauer +2 more
openaire +3 more sources
Current Cardiology Reviews, 2006
The recently discovered protein family of NADPH oxidases (NOX) is a group of transmembrane proteins that generate reactive oxygen species (ROS) by transferring electrons from NADPH onto molecular oxygen. The NOX proteins are the catalytic subunits that assemble with several regulatory subunits to form the catalytically active enzyme complex.
Hans W.M. Niessen +2 more
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The recently discovered protein family of NADPH oxidases (NOX) is a group of transmembrane proteins that generate reactive oxygen species (ROS) by transferring electrons from NADPH onto molecular oxygen. The NOX proteins are the catalytic subunits that assemble with several regulatory subunits to form the catalytically active enzyme complex.
Hans W.M. Niessen +2 more
openaire +2 more sources
NADPH oxidases and cardiac remodelling
Heart Failure Reviews, 2010A heart under chronic stress undergoes cardiac remodelling, a process that comprises structural and functional changes including cardiomyocyte hypertrophy, interstitial fibrosis, contractile dysfunction, cell death and ventricular dilatation. Reactive oxygen species (ROS)-dependent modulation of intracellular signalling is implicated in the development
Nabeebaccus, Adam +2 more
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NADPH oxidase and the respiratory burst
Seminars in Cell Biology, 1995Phagocytic cells possess an electron-transport system which accepts electrons from NADPH in the cytosol to reduce oxygen to the superoxide radical in the vacuolar lumen. The superoxide is instrumental in killing ingested microorganisms. Patients suffering from chronic granulomatous disease (CGD), in which this system is failing, are abnormally ...
Anthony W. Segal, Frans B. Wientjes
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Phospholipases and activation of the NADPH oxidase
European Journal of Haematology, 1993Abstract: The signal transductional mechanisms regulating the activation of NADPH oxidase, the respiratory burst enzyme in phagocytic cells, are not completely understood. Receptors for most physiologic stimuli trigger the activation of various phospholipases, including phospholipases A2, C, and D.
D E Agwu +3 more
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NADPH oxidase and heart failure
Current Opinion in Pharmacology, 2006Reactive oxygen species play important roles in the pathophysiology of chronic heart failure secondary to chronic left ventricular hypertrophy or myocardial infarction. Reactive oxygen species influence several components of the phenotype of the failing heart, including contractile function, interstitial fibrosis, endothelial dysfunction and myocyte ...
Murdoch, Colin E. +4 more
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The NADPH Oxidase Family and Its Inhibitors
Antioxidants & Redox Signaling, 2020Significance: The oxidative stress, resulting from an imbalance in the production and scavenging of reactive oxygen species (ROS), is known to be involved in the development and progression of several pathologies. The excess of ROS production is often due to an overactivation of nicotinamide adenine dinucleotide phosphate (NADPH) oxidases (NOX) and for
Chocry, Mathieu, Leloup, Ludovic
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