Results 271 to 280 of about 48,906 (319)

MFG‐E8 Accelerates Abdominal Aortic Aneurysm Formation by Enhancing ERK MAPK/NOX4 Axis‐Associated Oxidative Stress

open access: yesCell Proliferation, EarlyView.
MFG‐E8 promotes oxidative stress by upregulating NOX4 and activating the MAPK pathway, which increases ROS production and affects vascular smooth muscle cell (VSMC) apoptosis, thereby driving the progression of abdominal aortic aneurysm (AAA). Resveratrol can inhibit the expression and function of MFG‐E8, reduce ROS generation, and lower the incidence ...
Jie Xiao   +6 more
wiley   +1 more source

Salicylate plant defences reduce aphid nutritional quality and increase predator consumption

open access: yesEcological Entomology, EarlyView.
Salicylic acid‐induced defences diminish Macrosiphum euphorbiae performance and nutritional quality by reducing body protein and lipid content. Ladybird beetle predators (Hippodamia convergens) consumed more low‐quality aphids compared to high‐quality aphids, exhibiting compensatory feeding response to nutrient‐deficient p prey.
Bijay Subedi   +4 more
wiley   +1 more source

Genomic context analysis enables the discovery of an unusual NAD‐dependent racemase in phosphonate catabolism

open access: yesThe FEBS Journal, EarlyView.
The authors identify PbfF (previously annotated as a NAD‐dependent dehydrogenase) as a hitherto unknown enzyme in phosphonate catabolism. Guided by genome context analysis, they show that PbfF is actually a racemase, serving to degrade the natural compound (S)‐2‐amino‐1‐hydroxyethylphosphonate (S‐HAEP).
Francesca Ruffolo   +8 more
wiley   +1 more source

Studies of the membrane‐bound flavocytochrome MsrQ flavin mononucleotide (FMN)‐binding site reveal an unexpected ubiquinone cofactor

open access: yesThe FEBS Journal, EarlyView.
The membrane‐bound heme flavoprotein MsrQ is the specific electron donor for the periplasmic methionine sulfoxide reductase MsrP. Analysis of its flavin environment revealed that ubiquinone (UQ) is a cofactor for MsrQ. However, redox studies demonstrate that UQ cannot function as an electron donor for the MsrPQ system.
Philippe Carpentier   +9 more
wiley   +1 more source

Imeglimin improves hyperglycemia and hypoglycemia‐induced cell death and mitochondrial dysfunction in immortalized adult mouse Schwann IMS32 cells

open access: yesJournal of Diabetes Investigation, EarlyView.
Imeglimin reduces Schwann cell death by suppressing Complex I and oxidative stress, which may prevent diabetic neuropathy by protecting mitochondrial functions. ABSTRACT Aims/Introduction Imeglimin, a novel oral antidiabetic drug, enhances glucose‐stimulated insulin secretion, improves insulin sensitivity, and reduces mitochondrial reactive oxygen ...
Ayako Kato   +10 more
wiley   +1 more source

Systemic, Lifestyle and Environmental Modifying Factors in the Pathogenesis of Periodontitis

open access: yesJournal of Periodontal Research, EarlyView.
A variety of impacting factors in the pathogenesis of periodontitis exist, including systemic, lifestyle, and environmental factors. This review highlights the manifold mechanistic aspects of the link between the pathogenesis of periodontitis, addressing these numerous factors to supplement the long‐standing knowledge of the progression of the disease.
Groeger Sabine Elisabeth   +5 more
wiley   +1 more source

Stem Cells From Dental Pulp, Periodontal Tissues, and Other Oral Sources: Biological Concepts and Regenerative Potential

open access: yesJournal of Periodontal Research, EarlyView.
A graphical abstract recapping the different sources of dental, periodontal, and other oral‐derived mesenchymal stromal cells (MSCs) and their regenerative mechanisms and potentials. The review's article findings bridge fundamental biological science with translational advances, highlighting the significance of MSCs in craniofacial regenerative ...
Karim M. Fawzy El‐Sayed   +6 more
wiley   +1 more source

The Role of Oxidative Stress in Periodontitis

open access: yesJournal of Periodontal Research, EarlyView.
Oxidative stress is involved in multiple chemical reactions that take place in different intracellular organelles: mitochondria, rough endoplasmic reticulum, peroxisomes, autophagy, and aging, and can be influenced by exogenous factors: nutrition, physical activity, psychological status, environmental conditions, microbiome, and drugs.
Pedro Bullon   +3 more
wiley   +1 more source

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