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A burst of plant NADPH oxidases
Trends in Plant Science, 2012Reactive oxygen species (ROS) are highly reactive molecules able to damage cellular components but they also act as cell signalling elements. ROS are produced by many different enzymatic systems. Plant NADPH oxidases, also known as respiratory burst oxidase homologues (RBOHs), are the most thoroughly studied enzymatic ROS-generating systems and our ...
Christophe Dunand +6 more
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NADPH oxidases in cardiovascular disease
Free Radical Biology and Medicine, 2010Reactive oxygen species (ROS) contribute to several aspects of vascular diseases including ischemia-reperfusion injury, scavenging of nitric oxide, or stimulation of inflammation and hypertrophy. NADPH oxidases of the Nox family are differentially expressed in the cardiovascular system, induced or activated by cardiovascular risk factors and ...
Norbert Weissmann +2 more
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Current Cardiology Reviews, 2006
The recently discovered protein family of NADPH oxidases (NOX) is a group of transmembrane proteins that generate reactive oxygen species (ROS) by transferring electrons from NADPH onto molecular oxygen. The NOX proteins are the catalytic subunits that assemble with several regulatory subunits to form the catalytically active enzyme complex.
Hans W.M. Niessen +2 more
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The recently discovered protein family of NADPH oxidases (NOX) is a group of transmembrane proteins that generate reactive oxygen species (ROS) by transferring electrons from NADPH onto molecular oxygen. The NOX proteins are the catalytic subunits that assemble with several regulatory subunits to form the catalytically active enzyme complex.
Hans W.M. Niessen +2 more
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Assembly of the phagocyte NADPH oxidase
Histochemistry and Cell Biology, 2004Stimulated phagocytes undergo a burst in respiration whereby molecular oxygen is converted to superoxide anion through the action of an NADPH-dependent oxidase. The multicomponent phagocyte oxidase is unassembled and inactive in resting cells but assembles at the plasma or phagosomal membrane upon phagocyte activation.
William M. Nauseef, William M. Nauseef
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Receptor Activation of NADPH Oxidases
Antioxidants & Redox Signaling, 2010Reactive oxygen species (ROS) have been implicated in many intra- and intercellular processes. High levels of ROS are generated as part of the innate immunity in the respiratory burst of phagocytic cells. Low levels of ROS, however, are generated in a highly controlled manner by various cell types to act as second messengers in redox-sensitive pathways.
Michael Weitnauer +2 more
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Phospholipases and activation of the NADPH oxidase
European Journal of Haematology, 1993Abstract: The signal transductional mechanisms regulating the activation of NADPH oxidase, the respiratory burst enzyme in phagocytic cells, are not completely understood. Receptors for most physiologic stimuli trigger the activation of various phospholipases, including phospholipases A2, C, and D.
D E Agwu +3 more
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NADPH oxidases and cardiac remodelling
Heart Failure Reviews, 2010A heart under chronic stress undergoes cardiac remodelling, a process that comprises structural and functional changes including cardiomyocyte hypertrophy, interstitial fibrosis, contractile dysfunction, cell death and ventricular dilatation. Reactive oxygen species (ROS)-dependent modulation of intracellular signalling is implicated in the development
Nabeebaccus, Adam +2 more
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Blood, 1999
T HE NADPH OXIDASES are a group of plasma membrane–associated enzymes found in a variety of cells of mesodermal origin. The most thoroughly studied of these is the leukocyte NADPH oxidase, which is found in professional phagocytes and B lymphocytes.
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T HE NADPH OXIDASES are a group of plasma membrane–associated enzymes found in a variety of cells of mesodermal origin. The most thoroughly studied of these is the leukocyte NADPH oxidase, which is found in professional phagocytes and B lymphocytes.
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NADPH oxidase and the respiratory burst
Seminars in Cell Biology, 1995Phagocytic cells possess an electron-transport system which accepts electrons from NADPH in the cytosol to reduce oxygen to the superoxide radical in the vacuolar lumen. The superoxide is instrumental in killing ingested microorganisms. Patients suffering from chronic granulomatous disease (CGD), in which this system is failing, are abnormally ...
Anthony W. Segal, Frans B. Wientjes
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NADPH oxidase and heart failure
Current Opinion in Pharmacology, 2006Reactive oxygen species play important roles in the pathophysiology of chronic heart failure secondary to chronic left ventricular hypertrophy or myocardial infarction. Reactive oxygen species influence several components of the phenotype of the failing heart, including contractile function, interstitial fibrosis, endothelial dysfunction and myocyte ...
Murdoch, Colin E. +4 more
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