Results 71 to 80 of about 7,446 (257)
Cancer Reports, Volume 8, Issue 8, August 2025.ABSTRACT Background The PI3K/Akt/mTOR signaling pathway is commonly deregulated in different types of cancers, contributing to tumor proliferation, persistence, and resistance to treatment. Akt1, a crucial kinase within this pathway, plays a critical role in tumor progression and the occurrence of therapeutic resistance.
Shokoofeh Jamshidi +4 more
wiley +1 more source
Seasonal Host Shifts for Legionella Within an Industrial Water‐Cooling System
Environmental Microbiology Reports, Volume 17, Issue 4, August 2025.Taxonomic profiling for Legionella (the causative agent of Legionnaires' disease) and protist hosts within a water cooling tower showed seasonal peaks for Legionella that were associated with taxonomic shifts in the protist community. Legionella frequency was tracked using amplicon sequencing (blue line) and serogroup profiling (red line).
Suzanne Crull +8 more
wiley +1 more source
ACS Chemical Neuroscience, 2020 Primary amebic meningoencephalitis, caused by brain infection with a free-living ameba Naegleria fowleri, leads to an extensive inflammation of brain and death within 3-7 days after symptoms begin.
Jose Ignacio Escrig +2 more
semanticscholar +1 more source
Iranian Journal of Parasitology, 2014 Background: Naegleria is a free-living amoeba, and pathogenic Naegleria may pose a health risk to people exposed to recreational water. Our objective in this study was to determine if there are pathogenic amoebae in environmental water samples from ...
Wei Wang +4 more
doaj
Luminal Phospholipase D Attacks Bacterial Membranes in Dictyostelium discoideum Phagosomes
Molecular Microbiology, Volume 124, Issue 1, Page 54-65, July 2025.This study shows that PldX, a luminal Phospholipase D, is necessary for the efficient destruction of ingested Klebsiella pneumoniae bacteria in Dictyostelium discoideum phagosomes. PldX and the AlyL lysozyme together attack the bacterial membrane and permeabilize it. To date, the molecular substrate of PldX remains to be determined. ABSTRACT Phagocytic
Otmane Lamrabet +6 more
wiley +1 more source
Occurrence of Naegleria and Acanthamoeba in aquaria [PDF]
Applied and Environmental Microbiology, 1979 Samples from 24 aquaria were incubated at 28, 37, and 45 degrees C for the isolation of Naegleria and Acanthamoeba. Naegleria was the predominant genus (60.9%), whereas Acanthamoeba represented 15.5% of the isolates. No pathogenic N. fowleri was identified, although a high number of strains were closely related to this species. One isolate (Aq/9/1/45D)
openaire +3 more sources
Scientific Reports, 2020 Primary amoebic encephalitis (PAM) is a lethal disease caused by the opportunistic pathogen, Naegleria fowleri. This amoebic species is able to live freely in warm aquatic habitats and to infect children and young adults when they perform risk activities
Iñigo Arberas-Jiménez +10 more
semanticscholar +1 more source
International Journal of Infectious Diseases, 2018 Naegleria fowleri is the only Naegleria spp. known to cause an acute, fulminant, and rapidly fatal central nervous system infection in humans called primary amebic meningoencephalitis (PAM).
Ling-ling Zhang +6 more
doaj +1 more source
Iranian Journal of Parasitology, 2021 Background: Free-living amoeba (FLA) belonging to Acanthamoeba spp., Naegleria, and Balamuthia mandrillaris are the soil-born protozoa. This study aimed to survey the occurrence of FLA, including Acanthamoeba spp., B.
Asal Tanzifi +8 more
doaj +1 more source
Eukaryote‐Wide Distribution of a Family of Longin Domain‐Containing GAP Complexes for Small GTPases
Traffic, Volume 26, Issue 7-9, July/September 2025.The three longin domain‐containing GAP complexes ‐ CSW, folliculin, and GATOR1 ‐ have a sporadic but pan‐eukaryotic distribution and were likely already present in LECA in some form. Their catalytic longin domains contain highly conserved sequence motifs, some of which are shared with structurally similar proteins of Asgardarchaeota.
Anna M. G. Novák Vanclová +2 more
wiley +1 more source