Results 71 to 80 of about 8,595 (222)

Isolation and identification of free living amoeba (Naegleria and Acanthamoeba) in Shiraz water resources by morphological criteria

فصلنامه دانشگاه علوم پزشکی جهرم, 2012
Introduction: Free living amoebas are opportunistic pathogens that usually exist in different environmental conditions such as warm and polluted water, even in water supply networks and they could cause serious diseases in humans.
Shekofeh Ghadar-ghadr, Kavous Solhjoo, Mohammadjavad Norouz-nejad, Reyhaneh Rohi, Samaneh Zia-Jahromi   +4 more
doaj  

Flavonoids as Promising Akt1 Inhibitors in Cancer Medicine: Insights From Molecular Docking, Dynamics, DFT Calculations, and In Vitro Validation

Cancer Reports, Volume 8, Issue 8, August 2025.
ABSTRACT Background The PI3K/Akt/mTOR signaling pathway is commonly deregulated in different types of cancers, contributing to tumor proliferation, persistence, and resistance to treatment. Akt1, a crucial kinase within this pathway, plays a critical role in tumor progression and the occurrence of therapeutic resistance.
Shokoofeh Jamshidi, Ali Eghbalian, Setareh Shojaei, Amir Taherkhani, Mehran Feizi‐Dehnayebi   +4 more
wiley   +1 more source

Meningoencephalitis due to Naegleria fowleri in cattle in southern Brazil

Revista Brasileira de Parasitologia Veterinária
Naegleria fowleri is a free-living amoeba commonly found in the environment, mainly in fresh water and soil. This protozoon is occasionally involved in cases of fatal central nervous system disease in humans and other animal species.
Luan Cleber Henker, Raquel Aparecida Sales da Cruz, Fernando Soares da Silva, David Driemeier, Luciana Sonne, Francisco Alejandro Uzal, Saulo Petinatti Pavarini   +6 more
doaj   +1 more source

Enzymatic chokepoints and synergistic drug targets in the sterol biosynthesis pathway of Naegleria fowleri. [PDF]

PLoS Pathogens, 2018
Naegleria fowleri is a free-living amoeba that can also act as an opportunistic pathogen causing severe brain infection, primary amebic meningoencephalitis (PAM), in humans.
Wenxu Zhou, Anjan Debnath, Gareth Jennings, Hye Jee Hahn, Boden H Vanderloop, Minu Chaudhuri, W David Nes, Larissa M Podust   +7 more
doaj   +1 more source

Seasonal Host Shifts for Legionella Within an Industrial Water‐Cooling System

Environmental Microbiology Reports, Volume 17, Issue 4, August 2025.
Taxonomic profiling for Legionella (the causative agent of Legionnaires' disease) and protist hosts within a water cooling tower showed seasonal peaks for Legionella that were associated with taxonomic shifts in the protist community. Legionella frequency was tracked using amplicon sequencing (blue line) and serogroup profiling (red line).
Suzanne Crull, Emlyn Hammer, Allison E. Mann, Lauren M. O'Connell, Ashlyn Soule, Elizabeth Griffith, Thomas Blouin, Robin L. Brigmon, Vincent P. Richards   +8 more
wiley   +1 more source

Agglutination of Naegleria fowleri and Naegleria gruberi by antibodies in human serum [PDF]

Journal of Clinical Microbiology, 1983
The capability of serum samples from 423 human subjects to agglutinate rounded cells of Naegleria fowleri nN68 was assessed. Sera from the umbilical cords of seven infants failed to agglutinate N. fowleri cells. The median agglutination titer was 1:4 for sera from children through age 4 years, 1:8 for sera from juveniles 5 to 15 years of age, and 1:16 ...
M F, Reilly, F, Marciano-Cabral, D W, Bradley, S G, Bradley   +3 more
openaire   +2 more sources

Insights into the Diversity of Eukaryotes in Acid Mine Drainage Biofilm Communities [PDF]

, 2009
Microscopic eukaryotes are known to have important ecosystem functions, but their diversity in most environments remains vastly unexplored. Here we analyzed an 18S rRNA gene library from a subsurface iron- and sulfur-oxidizing microbial community growing
Baker, Brett J., Tyson, Gene W., Goosherst, Lindsey, Banfield, Jillian F.   +3 more
core   +1 more source

Luminal Phospholipase D Attacks Bacterial Membranes in Dictyostelium discoideum Phagosomes

Molecular Microbiology, Volume 124, Issue 1, Page 54-65, July 2025.
This study shows that PldX, a luminal Phospholipase D, is necessary for the efficient destruction of ingested Klebsiella pneumoniae bacteria in Dictyostelium discoideum phagosomes. PldX and the AlyL lysozyme together attack the bacterial membrane and permeabilize it. To date, the molecular substrate of PldX remains to be determined. ABSTRACT Phagocytic
Otmane Lamrabet, Raphael Munoz‐Ruiz, Imen Ayadi, Alixia Bourbon, Erwann Pain, Joseph Oddy, Pierre Cosson   +6 more
wiley   +1 more source

Encystation:the most prevalent and underinvestigated differentiation pathway of eukaryotes [PDF]

, 2018
Not long ago, protists were considered one of four eukaryote kingdoms, but recent gene-based phylogenies show that they contribute to all nine eukaryote subdomains.
Schaap, Pauline, Schilde, Christina
core   +2 more sources

Eukaryote‐Wide Distribution of a Family of Longin Domain‐Containing GAP Complexes for Small GTPases

Traffic, Volume 26, Issue 7-9, July/September 2025.
The three longin domain‐containing GAP complexes ‐ CSW, folliculin, and GATOR1 ‐ have a sporadic but pan‐eukaryotic distribution and were likely already present in LECA in some form. Their catalytic longin domains contain highly conserved sequence motifs, some of which are shared with structurally similar proteins of Asgardarchaeota.
Anna M. G. Novák Vanclová, Catherine L. Jackson, Joel B. Dacks   +2 more
wiley   +1 more source