Results 81 to 90 of about 7,446 (257)

Rare Infectious Diseases: Detection and Clinical Implications

iLABMED, Volume 3, Issue 2, Page 148-157, June 2025.
Rare infectious diseases are infections that are uncommon, have a low incidence, and are caused by newly emerging pathogens, cross‐species or ectopic infections, or host immunodeficiencies. The detection and diagnosis of rare infections is one of the main reasons for misdiagnosis and missed diagnosis.
Xin Qian, Yuxin Zhang, Yilin Ye, Qiange Lin, Junyou Lin, Xinrong Lu, Li Chen, Guiqin Sun   +7 more
wiley   +1 more source

Revolutionising Cancer Immunotherapy: Advancements and Prospects in Non‐Viral CAR‐NK Cell Engineering

Cell Proliferation, Volume 58, Issue 4, April 2025.
This manuscript provides a comprehensive overview of the state‐of‐the‐art in non‐viral CAR‐NK cell engineering, highlighting its potential to revolutionise cancer treatment. ABSTRACT The recent advancements in cancer immunotherapy have spotlighted the potential of natural killer (NK) cells, particularly chimeric antigen receptor (CAR)–transduced NK ...
Zhaokai Zhou, Yifeng Chen, Yuhao Ba, Hui Xu, Anning Zuo, Shutong Liu, Yuyuan Zhang, Siyuan Weng, Yuqing Ren, Peng Luo, Quan Cheng, Lulu Zuo, Shanshan Zhu, Xing Zhou, Chuhan Zhang, Yukang Chen, Xinwei Han, Teng Pan, Zaoqu Liu   +18 more
wiley   +1 more source

Detection of Naegleria spp. and Naegleria fowleri: a comparison of flagellation tests, ELISA and PCR

Water Science and Technology, 2003
To detect Naegleria spp, in particular Naegleria fowleri, the causative agent of human primary amoebic meningoencephalitis, a flagellation test (FT) is routinely used followed by a specific ELISA. A positive FT indicates the presence of Naegleria spp although some false negatives are likely to occur since parameters for enflagellation vary greatly.
F Seghi, L Duvivier, Priscilla Declerck, L Verelst, Jonas Behets, A Van Damme, Frans Ollevier   +6 more
openaire   +3 more sources

HMG-CoA Reductase Inhibitors as Drug Leads against Naegleria fowleri.

ACS Chemical Neuroscience, 2020
Primary amebic meningoencephalitis (PAM), caused by the free-living ameba Naegleria fowleri, has a fatality rate of over 97%. Treatment of PAM relies on amphotericin B in combination with other drugs, but few patients have survived with the existing drug
Hye Jee Hahn, R. Abagyan, L. Podust, Shantanu Roy, I. Ali, A. Debnath   +5 more
semanticscholar   +1 more source

Isolamento de amebas de vida livre potencialmente patogênicas em poeira de hospitais Isolation of potencially pathogenic free-living amoebas in hospital dust

Revista de Saúde Pública, 2003
OBJETIVO: Observar a ocorrência de amebas de vida livre dos gêneros Acanthamoeba e Naegleria em amostras de poeira coletadas em hospitais. MÉTODOS: Foram coletadas 132 amostras de poeira em dois hospitais do município de Presidente Prudente, São Paulo ...
Maria Aparecida da Silva, João Aristeu da Rosa   +1 more
doaj   +1 more source

18S rRNA Metagenomic Analysis of Nodular Gill Disease in Swiss Rainbow Trout (Oncorhynchus mykiss)

Journal of Fish Diseases, Volume 48, Issue 3, March 2025.
ABSTRACT Nodular gill disease (NGD) is a serious proliferative gill condition that affects farmed salmonids, particularly in Europe. While the cause of NGD remains unknown (and maybe multifactorial), various amoebae are often isolated from the gills of affected fish and can in some cases be seen associated with lesions by histopathology.
James W. Wynne, Chloe J. English, Stefania M. Vannetti, Megan Rigby, Petra R. Quezada‐Rodriguez, Ralph Knüsel, Christine Huynh, Heike Schmidt‐Posthaus   +7 more
wiley   +1 more source

Naegleria fowleri: Protein structures to facilitate drug discovery for the deadly, pathogenic free-living amoeba

bioRxiv, 2020
Naegleria fowleri is a pathogenic, thermophilic, free-living amoeba which causes primary amebic meningoencephalitis (PAM). Penetrating the olfactory mucosa, the brain-eating amoeba travels along the olfactory nerves, burrowing through the cribriform ...
Kayleigh Barrett, Logan M Tillery, J. Goldstein, Jared W. Lassner, Bram Osterhout, Nathan L. Tran, Lily Xu, Ryan M. Young, Justin Craig, Ian Chun, D. Dranow, J. Abendroth, S. Delker, D. Davies, S. Mayclin, B. Calhoun, M. Bolejack, B. Staker, S. Subramanian, I. Phan, D. Lorimer, P. Myler, T. Edwards, D. Kyle, C. Rice, James C. Morris, J. Leahy, Roman Manetsch, L. Barrett, Craig L. Smith, W. V. Van Voorhis   +30 more
semanticscholar   +1 more source

Meningoencephalitis due to Naegleria fowleri in cattle in southern Brazil

Revista Brasileira de Parasitologia Veterinária
Naegleria fowleri is a free-living amoeba commonly found in the environment, mainly in fresh water and soil. This protozoon is occasionally involved in cases of fatal central nervous system disease in humans and other animal species.
Luan Cleber Henker, Raquel Aparecida Sales da Cruz, Fernando Soares da Silva, David Driemeier, Luciana Sonne, Francisco Alejandro Uzal, Saulo Petinatti Pavarini   +6 more
doaj   +1 more source

Enzymatic chokepoints and synergistic drug targets in the sterol biosynthesis pathway of Naegleria fowleri. [PDF]

PLoS Pathogens, 2018
Naegleria fowleri is a free-living amoeba that can also act as an opportunistic pathogen causing severe brain infection, primary amebic meningoencephalitis (PAM), in humans.
Wenxu Zhou, Anjan Debnath, Gareth Jennings, Hye Jee Hahn, Boden H Vanderloop, Minu Chaudhuri, W David Nes, Larissa M Podust   +7 more
doaj   +1 more source

BASAL BODIES, BUT NOT CENTRIOLES, IN NAEGLERIA [PDF]

The Journal of Cell Biology, 1971
Amebae of Naegleria gruberi transform into flagellates whose basal bodies have the typical centriole-like structure. The amebae appear to lack any homologous structure, even during mitosis. Basal bodies are constructed during transformation and, in cells transforming synchronously at 25°C, they are first seen about 10 min before flagella are seen.
Chandler Fulton, Allan D. Dingle
openaire   +3 more sources