Cholera Toxin Subunit B as Adjuvant--An Accelerator in Protective Immunity and a Break in Autoimmunity [PDF]
, 2015 Cholera toxin subunit B (CTB) is the nontoxic portion of cholera toxin. Its affinity to the monosialotetrahexosylganglioside (GM1) that is broadly distributed in a variety of cell types including epithelial cells of the gut and antigen presenting cells ...
Stratmann, Thomas
core +2 more sources
A preliminary study on Naegleria species in water bodies of Kurunegala district, Sri Lanka
Sri Lankan Journal of Infectious Diseases, 2018 Introduction and Objective: Species belonging to the genus Naegleria are free-living ubiquitous protozoa. They have been isolated from most regions of the world. N.
JANS Gunarathna +2 more
doaj +1 more source
Recommendations for reproducibility of cerebrospinal fluid extracellular vesicle studies
Journal of Extracellular Vesicles, Volume 13, Issue 1, January 2024.Abstract Cerebrospinal fluid (CSF) is a clear, transparent fluid derived from blood plasma that protects the brain and spinal cord against mechanical shock, provides buoyancy, clears metabolic waste and transports extracellular components to remote sites in the brain.
Ursula S. Sandau +22 more
wiley +1 more source
Agglutination of Naegleria fowleri by Human Serum
Experimental Biology and Medicine, 1982 AbstractThe capability of 154 serum samples from pediatric outpatients and 101 samples from adults to agglutinate amoebae of Naegleria fowleri nN68 was assessed. Sera from all 19 infants tested had an agglutination titer of 1:4 or less; sera of toddlers had a median agglutination titer of 1:8 and those of adults, 1:16. Only 13 of 154 serum samples from
M F, Reilly, M K, Bradley, S G, Bradley
openaire +2 more sources
Glucose metabolism in the pathogenic free‐living amoebae: Tempting targets for treatment development
Chemical Biology &Drug Design, Volume 103, Issue 1, January 2024.Enzymes involved in glucose metabolism may be promising therapeutic targets for drug development against the pathogenic free‐living amoebae. Details about the enzyme sequence and structural properties make a compelling case for designing small molecule inhibitors that are specific to the amoebae and would not affect the host enzyme.AbstractPathogenic ...
Jillian E. Milanes +8 more
wiley +1 more source
Pharmacy Students’ Knowledge Assessment of Naegleria fowleri Infection
Scientifica, 2016 A cross-sectional study was conducted from April to August 2015 to assess the knowledge of pharmacy students towards Naegleria fowleri infection.
Sadia Shakeel +2 more
doaj +1 more source
In Vitro Efficacy of Ebselen and BAY 11-7082 Against Naegleria fowleri
Frontiers in Microbiology, 2018 Primary amebic meningoencephalitis (PAM) is a fatal infection caused by the free-living ameba Naegleria fowleri, popularly known as the “brain-eating ameba.” The drugs of choice in treating PAM are the antifungal amphotericin B and an antileishmanial ...
Anjan Debnath +5 more
doaj +1 more source
Identification of Immunogenic Antigens of Naegleria fowleri Adjuvanted by Cholera Toxin
Pathogens, 2020 The intranasal administration of Naegleria fowleri lysates plus cholera toxin (CT) increases protection against N. fowleri meningoencephalitis in mice, suggesting that humoral immune response mediated by antibodies is crucial to induce protection against
Saúl Rojas-Hernández +7 more
doaj +1 more source
The identification of free-living environmental isolates of amoebae from Bulgaria [PDF]
, 2018 A survey was carried out in Bulgaria to determine the presence of free-living amoebae (FLA) from environmental sources. In 171 (61.1%) of 280 samples, isolates of Acanthamoeba with group II or III morphology, as well as Hartmannella spp.
Aspöck, Horst +8 more
core
Limited Activity Of Miltefosine In Murine Models Of Cryptococcal Meningoencephalitis And Disseminated Cryptococcosis [PDF]
, 2013 Miltefosine is an alkyl phosphocholine with good oral bioavailability and in vitro activity against Cryptococcus species that has gained interest as an additional agent for cryptococcal infections.
Bocanegra, Rosie +5 more
core +1 more source