Results 211 to 220 of about 33,122 (238)

Factors associated with potentially inappropriate medication use, medication underuse and overuse in older adults in the German National Cohort

open access: yesJournal of Internal Medicine, EarlyView.
Abstract Background Effectively identifying individuals exposed to drug underuse, overuse and potentially inappropriate medication (PIM) in older adults is essential for minimizing preventable drug‐related harms. Methods We analysed data from 54,296 individuals aged 60–74 years from the German National Cohort (NAKO).
Miriam Degen   +18 more
wiley   +1 more source

Exposure to Gestational Intermittent Hypoxia Does Not Impair the Metabolic Function or Accelerate the Biological Ageing Process of Offspring of Either Sex

open access: yesJournal of Sleep Research, EarlyView.
ABSTRACT Obstructive sleep apnea (OSA), marked by intermittent hypoxia, is associated with obesity, type 2 diabetes and metabolic associated fatty liver disease. In pregnancy, it remains underdiagnosed despite links to gestational diabetes, hypertension, and foetal growth restriction.
Esther Valverde‐Perez   +6 more
wiley   +1 more source

Porphyromonas gingivalis Outer Membrane Vesicles‐Associated DNA Triggers Inflammation by Inducing IL‐6 in Astrocytes

open access: yesMolecular Oral Microbiology, EarlyView.
Pg releases OMVs which contain Pg genomic DNA. The Pg OMVs‐associated DNA is incorporated into astrocytes via endocytosis and increases IL‐6 mRNA expression via TLR9. These effects of Pg OMVs may induce neuroinflammation, which could contribute to the onset and progression of AD in periodontal disease.
Ayu Takai   +7 more
wiley   +1 more source

Shigella Effector VirA Suppresses Plant Immunity by Compromising PRA1.F3‐Dependent Accumulation of FLS2 at the Plasma Membrane

open access: yesPlant, Cell &Environment, EarlyView.
ABSTRACT Surface immune receptors such as flagellin‐sensitive 2 (FLS2) are critical for plant defence, and their accumulation at the plasma membrane is tightly controlled by the endomembrane system. Here, we identify the Arabidopsis thaliana prenylated Rab acceptor PRA1.F3 as a positive regulator required for efficient accumulation of FLS2 at the ...
Sung Hee Jo   +4 more
wiley   +1 more source

Targeting OxLDL-mediated CD36 + CAF reprogramming potentiates PD-1 immunotherapy in osteosarcoma. [PDF]

open access: yesMol Cancer
Zeng A   +15 more
europepmc   +1 more source

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