Results 31 to 40 of about 71,479 (314)

Systematic review and meta-analysis of placebo cure in onychomycosis clinical trials

JAAD Reviews
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Julianne M. Falotico, MD, Zachary J.K. Neubauer, BS, Anjile An, MPH, Shari R. Lipner, MD, PhD   +3 more
doaj   +1 more source

Nail Involvement in Alopecia Areata: A Questionnaire-based Survey on Clinical Signs, Impact on Quality of Life and Review of the Literature

Acta Dermato-Venereologica, 2017
Alopecia areata (AA) is an immune-mediated disease causing temporary or permanent hair loss. Up to 46% of patients with AA also have nail involvement. The aim of this study was to determine the presence, types, and clinical implications of nail changes ...
Yvonne B.M. Roest, Henriët van Middendorp, Andrea W.M. Evers, Peter C.M. van de Kerkhof, Marcel C. Pasch   +4 more
doaj   +1 more source

Nail changes in systemic diseases

South African Family Practice, 2010
Discerning between actual nail conditions and nail changes associated with systemic disease is a very important and interesting part of any clinical examination.
Mojakgomo H. Motswaledi, M.C. Mayayise
doaj   +1 more source

Advancement and independent validation of a deep learning-based tool for automated scoring of nail psoriasis severity using the modified nail psoriasis severity index

Frontiers in Medicine
ObjectiveTo improve and validate a convolutional neural network (CNN)-based model for the automated scoring of nail psoriasis severity using the modified Nail Psoriasis Severity Index (mNAPSI) with adequate accuracy across all severity classes and ...
Stephan Kemenes, Stephan Kemenes, Liu Chang, Maja Schlereth, Rita Noversa de Sousa, Rita Noversa de Sousa, Ioanna Minopoulou, Pauline Fenzl, Pauline Fenzl, Giulia Corte, Giulia Corte, Melek Yalcin Mutlu, Melek Yalcin Mutlu, Michael Wolfgang Höner, Michael Wolfgang Höner, Ioannis Sagonas, Ioannis Sagonas, Birte Coppers, Birte Coppers, Anna-Maria Liphardt, Anna-Maria Liphardt, David Simon, Arnd Kleyer, Lukas Folle, Michael Sticherling, Michael Sticherling, Georg Schett, Georg Schett, Andreas Maier, Filippo Fagni, Filippo Fagni   +30 more
doaj   +1 more source

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Titanium exposure and yellow nail syndrome

Respiratory Medicine Case Reports, 2015
Yellow nail syndrome is a rare disease of unclear etiology. We describe a patient who develops yellow nail syndrome, with primary nail and sinus manifestations, shortly after amalgam dental implants. A study of the patient's nail shedding showed elevated
Ali Ataya, Kristopher P. Kline, Jessica Cope, Hassan Alnuaimat   +3 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source