Results 41 to 50 of about 180,929 (353)

Advancement and independent validation of a deep learning-based tool for automated scoring of nail psoriasis severity using the modified nail psoriasis severity index

Frontiers in Medicine
ObjectiveTo improve and validate a convolutional neural network (CNN)-based model for the automated scoring of nail psoriasis severity using the modified Nail Psoriasis Severity Index (mNAPSI) with adequate accuracy across all severity classes and ...
Stephan Kemenes, Stephan Kemenes, Liu Chang, Maja Schlereth, Rita Noversa de Sousa, Rita Noversa de Sousa, Ioanna Minopoulou, Pauline Fenzl, Pauline Fenzl, Giulia Corte, Giulia Corte, Melek Yalcin Mutlu, Melek Yalcin Mutlu, Michael Wolfgang Höner, Michael Wolfgang Höner, Ioannis Sagonas, Ioannis Sagonas, Birte Coppers, Birte Coppers, Anna-Maria Liphardt, Anna-Maria Liphardt, David Simon, Arnd Kleyer, Lukas Folle, Michael Sticherling, Michael Sticherling, Georg Schett, Georg Schett, Andreas Maier, Filippo Fagni, Filippo Fagni   +30 more
doaj   +1 more source

Dermatophytes’ identification by Matrix-assisted laser desorption ionization-time of flight mass spectrometry. (MALDI-TOF MS) - the experience of a clinical laboratory [PDF]

, 2019
Objectives: Dermatophytes are a challenging group of fungi that infect the keratinized tissues. The taxonomy of these fungi has changed recently with the reclassification of some species and description of new ones. However, many clinical laboratories
Sabino, R., Simões, D., Simões, H., Verissimo, C.   +3 more
core   +1 more source

A working model for cytoplasmic assembly of H/ACA snoRNPs

FEBS Letters, EarlyView.
Dyskerin is the component of nuclear H/ACA ribonucleoproteins (RNPs) endowed with pseudouridine synthase catalytic activity. Two isoforms of human dyskerin have been characterized: the abundant Iso1, mainly nuclear, and the shorter Iso3, mainly cytoplasmic but occasionally imported into nuclei.
Alberto Angrisani, Maria Furia
wiley   +1 more source

Titanium exposure and yellow nail syndrome

Respiratory Medicine Case Reports, 2015
Yellow nail syndrome is a rare disease of unclear etiology. We describe a patient who develops yellow nail syndrome, with primary nail and sinus manifestations, shortly after amalgam dental implants. A study of the patient's nail shedding showed elevated
Ali Ataya, Kristopher P. Kline, Jessica Cope, Hassan Alnuaimat   +3 more
doaj   +1 more source

RAD50 missense variants differentially affect the DNA damage response and mitotic progression

FEBS Letters, EarlyView.
RAD50 incorporates into the MRN complex and initiates the DNA damage response. Furthermore, RAD50 promotes mitotic progression. RAD50 missense variants capable of forming an MRN complex supported the DNA damage response and mitotic features to different extents in complementation experiments, indicating these functions are separable and might impact ...
Hanna Redeker, Swantje Kebel, Lea Völkening, Anna Vatselia, Louisa Weinhold, Girmay Asgedom, Axel Schambach, Detlev Schindler, Thilo Dörk, Kristine Bousset   +9 more
wiley   +1 more source

Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target

FEBS Letters, EarlyView.
This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz, Milagros Siebeck Caturelli, Lina S. Lehmann, Florian Kurth, Alexander G. Maier, Kai Matuschewski   +5 more
wiley   +1 more source

Updated Perspectives on the Diagnosis and Management of Onychomycosis

Clinical, Cosmetic and Investigational Dermatology, 2022
Julianne M Falotico,1 Shari R Lipner2 1Renaissance School of Medicine at Stony Brook University, Stony Brook, NY, USA; 2Weill Cornell Medicine, Department of Dermatology, New York, NY, USACorrespondence: Shari R Lipner, Weill Cornell Medicine, Department
Falotico JM, Lipner SR
doaj  

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Onychogryphosis in tuberous sclerosis complex: an unusual feature [PDF]

Anais Brasileiros de Dermatologia, 2016
Onychogryphosis is an acquired nail plate change. It often affects the toenail and is characterized by an opaque, yellow-brownish nail plate that is distorted, grossly thickened, elongated, and partly curved resembling a ram's horn.
Xiang-chun Han, Li-qiang Zheng, Tie-gang Zheng   +2 more
doaj   +1 more source

Dermoscopy: a useful auxiliary tool in the diagnosis of type 1 segmental Darier's disease [PDF]

, 2016
Type 1 segmental Darier's disease is a blaschkolinear variant of Darier's disease resulting from a postzygotic mosaicism. Since it usually lacks diagnostic clues typical of the generalized form, including positive family history of the disease, nail and ...
Errichetti, Enzo, Maione, Vincenzo, Pegolo, Enrico, Stinco, Giuseppe   +3 more
core   +2 more sources