Results 191 to 200 of about 56,585 (261)

NDFIP2 Suppresses Colorectal Cancer Metastasis Through DDX3X‐Dependent R‐Loop Remodeling and GNG13 Transcriptional Activation

Advanced Science, EarlyView.
NDFIP2 recruits NEDD4 to promote K48‐linked ubiquitination and proteasomal degradation of DDX3X, leading to R‐loop accumulation and CTCF‐dependent suppression of GNG13 transcription. Consequently, PI3K/AKT signaling, EMT, stemness, and colorectal cancer metastasis are inhibited.
Enjian Zhang, Yanfang Li, Jiaxin Shu, Shang Xu, Heng Lv, Chong Zhang, Pengbo Zhang, Nai Wu, Shuai Gong, Xiuzhong Zhang, Zeqiang Ren, Xin Liu, Yi Zhang   +12 more
wiley   +1 more source

Clinical Rationale for Procedural Steps When Performing Non-Incisional Nail Surgery: A Scoping Review. [PDF]

J Foot Ankle Res
Horn A, Robinson C, Donnan L.
europepmc   +1 more source

The Novel Viral Non‐Coding RNA LMP2A‐IT1 Promotes the Lytic Replication of EBV

Advanced Science, EarlyView.
Decades after its discovery, EBV's genome still harbours unannotated “dark matter”. LMP2A‐IT1, a novel EBV‐encoded transcript identified in this work, is strongly upregulated during lytic replication and promotes BZLF1 expression, likely through activation of inflammatory responses, thereby enhancing viral propagation in a self‐reinforcing positive ...
Zheng‐Zhou Lu, Jun‐Fei Wu, Nannan Zhu, Ming‐Hui Yang, Le‐Le Zhang, Yuan‐Tao Liu, Wei‐Jun Chen, Jin‐Kun Tang, Jia‐Wei Ge, Chao‐Bo Lei, Tao Zhang, Yu Wang, Chao‐Yun Huang, Qian Zhong, Mu‐Sheng Zeng, Yan Li   +15 more
wiley   +1 more source

Refractory Periungual Warts Treated with Filiform Fire Needle Combined with Warming-Yang and Collateral-Dredging Chinese Medicine Soak: A Two-Case Report. [PDF]

Clin Cosmet Investig Dermatol
Lyu S, Chong Z, Yu T, Ruan C.
europepmc   +1 more source

Non‐Canonical Function of DDX21 in Fetal Hematopoiesis Antagonizes KDM5A‐Mediated Repression of Ribosomal and Hematopoietic Genes

Advanced Science, EarlyView.
This study demonstrates a mechanism by which RNA helicase DDX21 coordinates the transcription of hematopoietic and ribosomal genes by interacting with the H3K4me3 demethylase KDM5A. The DDX21‐KDM5A complex co‐occupies active genes in hematopoietic progenitors, thereby ensuring their rapid proliferation during fetal hematopoiesis.
Adrian On‐Wah Leung, Chang Li, Xianyin Huang, Zhuming Fan, Yuning Chen, Jiaxing Liu, Hong Man Lin, Xiaoming Cui, Fujia Zhang, Ruoxi Niu, Kam Tong Leung, Boxian Huang, Hoi‐Hung Cheung   +12 more
wiley   +1 more source

Maladaptive immune-fibrotic axis drives impaired long bone regeneration under mechanical instability. [PDF]

Sci Adv
Patrick MD, Ahn J, Hankenson KD, Annamalai RT.   +3 more
europepmc   +1 more source

Persistent Drug Reaction With Eosinophilia and Systemic Symptoms (DRESS) Syndrome Associated With Vancomycin-Impregnated Orthopedic Cement: A Case Report. [PDF]

Cureus
Dschaak TJ.
europepmc   +1 more source

In third-generation humeral intramedullary nailing of proximal humerus fractures, a more medial and posterior starting point improves alignment, and alignment improves with surgeon experience. [PDF]

JSES Rev Rep Tech
Qubain L, Jawad MU, Eisenberg M, Patel M, Amini MH.   +4 more
europepmc   +1 more source

Bony mallet finger: a novel surgical approach to the terminal tendon insertion using a dual parallel incision - A case series study. [PDF]

Int J Burns Trauma
Zhao W, Zhao M.
europepmc   +1 more source

Molecular and Conventional Tests in Onychomycosis: A Systematic Review of Paired Diagnostic Discordance and Clinical Interpretation. [PDF]

Cureus
Bigge S, Bigge B.
europepmc   +1 more source