Results 261 to 270 of about 129,551 (357)

Microcystin‐LR Triggers Renal Tubular Ferroptosis Through Epigenetic Repression of GPX4: Implications for Environmental Nephrotoxicity

Advanced Science, EarlyView.
MC‐LR stabilizes DNMT1/3a by blocking their ubiquitin‐mediated degradation, leading to Gpx4 promoter hypermethylation and E2F4/NCoR‐associated transcriptional repression, which drives renal tubular ferroptosis in mice. Pharmacological inhibition of DNA methylation (SGI‐1027) or ferroptosis (Fer‐1) disrupts this DNMT‐GPX4 axis, thereby alleviating MC‐LR‐
Shaoru Zhang, Qi Gao, Yi Peng, Huan Zhang, Qi Shen, Meihong Guo, Yuqing Gong, Lei Chu, Weidong Wu, Yanting Wen, Wangsen Cao, Yong Wang, Lihui Wang   +12 more
wiley   +1 more source

Rare variant of ankyloblepharon-ectodermal defect-cleft lip/cleft palate syndrome: Curly hair-ankyloblepharon-nail disease syndrome

, 2018
Debdeep Mitra, Ajay Chopra, Renu Kandpal, Reetu Agarwal   +3 more
openalex   +2 more sources

Distal Tibial Atrophic Pseudoarthrosis Treated with Vascularized Fibular Graft and Ankle Arthrodesis Nail: A Multidisciplinary Orthoplastic Case Report. [PDF]

J Orthop Case Rep
Mayorga-Naranjo D, Ortega-Yago A, Ruiz-Cases A, Baixauli-García I, Argüelles-Linares F, Baeza-Oliete J.   +5 more
europepmc   +1 more source

IGF‐1 Deficiency Serves as an Integrated Biomarker Pathogenic Driver and Predictor in Poor Ovarian Response

Advanced Science, EarlyView.
IGF‐1 deficiency underlies poor ovarian response (POR), as reduced levels in follicular fluid and granulosa cells impair antral follicle formation and compromise reproductive outcomes. Including IGF‐1 as a biomarker significantly enhances the accuracy of models predicting both PORrisk and pregnancy success.
Zhu Hu, Yuanyuan Yu, Guanyou Huang, Jinnan Li, Chao Yang, Aizhuan Long, Jia Tang, Tengxiang Chen, Shuyun Zhao, Tuo Zhang   +9 more
wiley   +1 more source

A Treatise on Corns, Bunions, the Diseases of the Nails, and General Management of the Feet. [PDF]

openalex  

What Is the Diagnostic Capacity of Existing Severity Scoring Tools for Nail Psoriasis? [PDF]

Int J Dermatol
Rikken ECC, van Hal TW, van den Reek JMPA, Klaassen KMG, de Jong EMGJ, Pasch MC.   +5 more
europepmc   +1 more source

Chloroplast Stress Signals Orchestrate Epidermis‐Specific Remodeling of Mitochondria and ER Under High Light

Advanced Science, EarlyView.
High light exposure triggers an epidermis‐specific remodeling of mitochondria and ER in Arabidopsis, driven by chloroplast‐derived signals. Live‐cell imaging shows that HL rapidly suppresses mitochondrial motility, followed by fusion‐driven elongation and ER cisternal expansion.
Evan R. Angelos, Hee‐Seung Choi, Jingzhe Guo, Andrea A. Zanini, Tessa M. Burch‐Smith, Emily Snyder, Matthew Part, Wilhelmina van de Ven, Manhoi Hur, Gerd Ulrich Balcke, Alain Tissier, Quanqing Zhang, Katayoon Dehesh   +12 more
wiley   +1 more source

Clinical Outcomes of the Cephalomedullary Nail with Supplementary Screws versus Multiple Cannulated Screws for Femoral Neck Fracture in Young and Active Patients. [PDF]

Hip Pelvis
Kwon YU, Lee WH, Lee HY.
europepmc   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Finite element analysis of different cephalomedullary nail treatments for basicervical femoral neck fracture. [PDF]

Sci Rep
Gao Y, Chen X, Cao C, Xing H, Du Z, Cao F, Bao T, Huang G, Wang G.   +8 more
europepmc   +1 more source