Results 131 to 140 of about 133,063 (223)
Skin Diseases in Laboratory Mice: Approaches to Drug Target Identification and Efficacy Screening. [PDF]
Methods Mol Biol, 2016 Sundberg JP +3 more
europepmc +1 more source
Advanced Science, EarlyView.The release of COL6A3 by fibroblasts is sensed by the CD44 receptor on melanocytes, activating glutathione (GSH) metabolism and increasing melanocyte survival during skin organoid culture. SEMA3C released by bulge cells binds to the NRP1 receptor on melanocytes, regulating microtubule stability and promoting melanocyte recruitment and function during ...
Tingting Li +17 more
wiley +1 more source
Advanced Science, EarlyView.Cisplatin causes reactive oxygen species accumulation, leading to apoptosis and inflammation in cochlear hair cells. Small extracellular vesicles primarily derived from the damaged hair cells likely contribute to cisplatin‐induced ototoxicity, carrying a variety of microRNAs and proteins.
Jingru Ai +14 more
wiley +1 more source
Detecting gunshots using wearable accelerometers. [PDF]
PLoS One, 2014 Loeffler CE.
europepmc +1 more source
Advanced Science, EarlyView.The proposed working model for how adipocytes participate in cisplatin resistance in osteosarcoma. The adipocytes secret A1BG and stabilize NAMPT, leading to increased NAD⁺ levels and subsequent increased PARP1‐mediated DNA repair, resulting in cisplatin resistance in osteosarcoma finally.
Yonghui Liang +8 more
wiley +1 more source
Mild Blast Injury Produces Acute Changes in Basal Intracellular Calcium Levels and Activity Patterns in Mouse Hippocampal Neurons. [PDF]
J Neurotrauma, 2018 Hansen KR +9 more
europepmc +1 more source
Loss of STARD7 Triggers Metabolic Reprogramming and Cell Cycle Arrest in Breast Cancer
Advanced Science, EarlyView.Breast cancer cells undergo metabolic and transcriptomic reprogramming to support aberrant cell proliferation. Their mitochondria rely on the transfer of phosphatidylcholine from the endoplasmic reticulum to their membranes by STARD7, a candidate upregulated in breast cancer, to be functional.
Ewelina Dondajewska +18 more
wiley +1 more source
USP45 Represses Melanoma Development by Deubiquitinating and Stabilizing Tumor Suppressor MRGPRF
Advanced Science, EarlyView.USP45 acts as a melanoma suppressor by stabilizing MRGPRF, which weakens the PI3K/AKT pathway, suppresses tumor growth, and reduces melanoma cell migration and invasion. Abstract Melanoma, a highly malignant skin cancer, has seen a rising incidence and death toll. MRGPRF is a novel melanoma suppressor that inhibits the PI3K/AKT pathway.
Wancong Zhang +10 more
wiley +1 more source