Results 141 to 150 of about 135,032 (257)

Use of Frequency Measurement to Assess Ilizarov Wire Tension for Education and Training Purposes. [PDF]

Strategies Trauma Limb Reconstr
Russell SP.
europepmc   +1 more source

Novel ATR/PARP1 Dual Inhibitors Demonstrate Synergistic Antitumor Efficacy in Triple‐Negative Breast Cancer Models

Advanced Science, EarlyView.
Novel ATR/PARP1 dual inhibitors are developed for the first time. Advanced lead B8 effectively reduces cell viability in vitro and suppresses tumor growth in vivo, with better potency than ATRi and PARPi alone or in combination. Mechanistically, B8 induces apoptosis, arrests the cell cycle, and inhibits cancer cells colony formation, migration, and ...
Yuan Gao, Jiawei Zhou, Chen‐Chen Wang, Zong‐Hao Wang, Nian‐Dong Mao, Meng‐Lan He, Peng‐Peng Zhang, Ping Huang, Guo‐Wei Ye, Yu‐Qing Zhang, Feng‐Hui Tang, Hang Zhang, Tian Xie, Xiang‐Yang Ye   +13 more
wiley   +1 more source

Novel Cyano‐Artemisinin Dimer ZQJ29 Targets PARP1 to Induce Ferroptosis in Pancreatic Cancer Treatment

Advanced Science, EarlyView.
A novel artemisinin derivative dimer has been synthesized, and its significant potential as an anti‐cancer agent. The study indicated that ZQJ29 effectively inhibited the proliferation of pancreatic cancer cells in vitro and in vivo. Additionally, these investigations have unveiled ZQJ29 as a new potent PARP1 inhibitor, with the capability to induce ...
Jianping Chen, Lingyun Yue, Yanna Pan, Bingying Jiang, Junfeng Wan, Haixia Lin, Fujiang Guo, Huiyu Li, Yajuan Li, Qingjie Zhao   +9 more
wiley   +1 more source

Serious injury and fatality investigations involving pneumatic nail guns, 1985-2012. [PDF]

Am J Ind Med, 2016
Lowe BD, Albers JT, Hudock SD, Krieg EF.
europepmc   +1 more source

Nephronectin (NPNT) is a Crucial Determinant of Idiopathic Pulmonary Fibrosis: Modulating Cellular Senescence via the ITGA3/YAP1 Signaling Axis

Advanced Science, EarlyView.
Through a comprehensive multi‐omics analysis, this study identifies a marked reduction in Nephronectin (NPNT) expression within fibrotic lung tissue. This reduction impairs the binding capability to the ITGA3 receptor, consequently causing YAP1 to persist in the cytoplasm, where it undergoes degradation.
Jiayu Guo, Yan Wang, Qiudi Liu, Zhaoyang Luo, Xiaomu Tian, Yuquan Wang, Yang Liu, Zhiwei Ning, Yingying Guo, Huiying Gao, Xinyue Wang, Jinglong Feng, Mengmeng Liu, Dina Saifullina, Yixin Zhang, Tengfei Pan, Yu Bian, Tao Ban, Tianyu Li, Yunyan Gu, Haihai Liang   +20 more
wiley   +1 more source

Optimizing paper sludge content and particle size to enhance particleboard properties. [PDF]

Sci Rep
Mehrvan K, Jonoobi M, Ashori A, Ahmadi P.   +3 more
europepmc   +1 more source

NorthEuraLex: a wide-coverage lexical database of Northern Eurasia. [PDF]

Lang Resour Eval, 2020
Dellert J, Daneyko T, Münch A, Ladygina A, Buch A, Clarius N, Grigorjew I, Balabel M, Boga HI, Baysarova Z, Mühlenbernd R, Wahle J, Jäger G.   +12 more
europepmc   +1 more source

Physiotherapy for pain and disability in adults with complex regional pain syndrome (CRPS) types I and II. [PDF]

Cochrane Database Syst Rev, 2022
Smart KM, Ferraro MC, Wand BM, O'Connell NE.   +3 more
europepmc   +1 more source

RSPO2 Coordinates with GDF9:BMP15 Heterodimers to Promote Granulosa Cell and Oocyte Development in Mice

Advanced Science, EarlyView.
RSPO2 and GDF9:BMP15 heterodimers—core components of oocyte‐secreted factors (OSFs)—coordinate to shape the molecular architecture of preantral granulosa cells via gene‐specific synergistic and antagonistic regulation, mediated through CTNNB1–SMAD2 signaling crosstalk.
Yingmei Wang, Hongjiang Li, Liji You, Shuhui Wang, Jinglei Bie, Ziyang Su, Lanying Shi, You‐Qiang Su   +7 more
wiley   +1 more source

Mechanical Behaviors and Fatigue Performances of Ballastless Tracks Laid on Long-Span Cable-Stayed Bridges with Different Arrangements. [PDF]

Sensors (Basel), 2019
Sheng X, Zheng W, Zhu Z.
europepmc   +1 more source