Results 11 to 20 of about 3,079 (260)

Investigation Of Different Fasteners In Roof Truss Elements In The Woodworking Industry

Turkish Journal of Forestry
In this study, the compressive safety stresses of the roof trusses were determined depending on the different joining angles (90° at the rafter, 90° at the base and bisector) at the connection points of the rafter and base elements used in traditional ...
Mert Arslan, Emin Berk Kaya, İbrahim Pazarkaya, Nurettin Gökbulut, Musa Kaya, Nihat Döngel, H.özgür İmirzi, Ramazan Bülbül   +7 more
doaj   +1 more source

Governing Yield Modes for Common Bolted and Nailed Wood Connections

, 2000
Connections in wood structures are important when designing for ductility. The 1997 Uniform Building Code has taken this into consideration when designating wind and earthquake load duration factors for connections.
Fridley, Kenneth J, Peters, Jeffrey J, Pollock, David, Tucker, Brian J   +3 more
core   +1 more source

Corrosion of fasteners in furfurylated wood : final report after 9 years exposure outdoors [PDF]

, 2017
Corrosion of some common fastener materials – mild steel, stainless steel, zinc-coated steel, brass and Sanbond Z (nickel, zinc and chromate) coated steel – has been evaluated after nine years’ exposure outdoors in untreated Scots pine and furfurylated ...
Andersson, Bo-Lennart, Jermer, Jöran, Schalnat, Joanna   +2 more
core   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source

Numerical modelling of steel-to-timber joints and connectors for CLT structures [PDF]

, 2016
The mechanical behaviour of steel-to-timber joints with annular-ringed shank nails is investigated using numerical modelling and a component approach. These joints are used in Cross-Laminated Timber (CLT) buildings to anchor metal connectors such as hold-
Fragiacomo, Massimo, Izzi, Matteo, Polastri, Andrea, Rinaldin, Giovanni   +3 more
core  

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

Molecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

Olaparib synergy screen reveals Exemestane induces replication stress in triple‐negative breast cancer

Molecular Oncology, EarlyView.
Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh, Liping Su, Suet Lin Chia, Xiaohe Tian, Haslina Ahmad, Martin R. Gill   +5 more
wiley   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Robot-friendly connector [PDF]

, 1993
Robot friendly connectors, which, in one aspect, are truss joints with two parts, a receptacle and a joint, are presented. The joints have a head which is loosely inserted into the receptacle and is then tightened and aligned.
Parma, George F., Ruiz, Steve C., Vandeberghe, Mark H.   +2 more
core   +1 more source