Results 11 to 20 of about 3,088 (250)
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Numerical modelling of steel-to-timber joints and connectors for CLT structures [PDF]
, 2016 The mechanical behaviour of steel-to-timber joints with annular-ringed shank nails is investigated using numerical modelling and a component approach. These joints are used in Cross-Laminated Timber (CLT) buildings to anchor metal connectors such as hold-
Fragiacomo, Massimo +3 more
core
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Seismic Performance of Anchored Brick Veneer [PDF]
, 2009 A study was conducted on the out-of-plane seismic performance of anchored brick veneer with wood-frame backup wall systems, to evaluate prescriptive design requirements and current construction practices.
LaFave, James M. +1 more
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Empirically derived connection design properties for Guadua bamboo [PDF]
, 2018 Three connection design properties (dowel embedment strength, slip modulus and screw withdrawal capacity) were determined for one species of bamboo (Guadua angustifolia Kunth) using experimental methods adopted from timber engineering.
Malkowska, Dominika, Trujillo, David
core +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Robot-friendly connector [PDF]
, 1993 Robot friendly connectors, which, in one aspect, are truss joints with two parts, a receptacle and a joint, are presented. The joints have a head which is loosely inserted into the receptacle and is then tightened and aligned.
Parma, George F. +2 more
core +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Test Excavations at the Spanish Governor\u27s Palace, San Antonio, Texas [PDF]
, 1997 Test excavations were carried out in October 1996 by the Center for Archaeological Research of The University of Texas at San Antonio in front of the Spanish Governor\u27s Palace in Military Plaza in downtown San Antonio.
Fox, Anne A.
core +2 more sources