Results 21 to 30 of about 3,088 (250)
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Defining appropriate limit states for design of timber connections in Australia and New Zealand [PDF]
, 2007 Both Australia and New Zealand design standards for timber structures are in limit states format, but these are first generation soft conversions of previous working stress design standards. It is anticipated that development of a new combined Australian
Crews, K
core
Historic Archeological Investigations at Roberts Cemetery Near Troy, Bell County, Texas [PDF]
, 2014 A preliminary archeological investigation was conducted in 2008 at Roberts Cemetery near Troy, Texas, as part of the Texas Department of Transportation’s planned expansion of Interstate Highway 35.
Abbott, James T. +5 more
core +2 more sources
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
LRFD for Engineered Wood Structures - Connection Behavioral Equations
, 1993 A new design specification for engineered wood structures has been proposed in load and resistance factor design (LRFD) format. This paper provides an overview of the proposed LRFD connections design criteria.
McLain, Thomas E +3 more
core +1 more source
Overview of molecular signatures of senescence and associated resources: pros and cons
FEBS Open Bio, EarlyView.Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas +6 more
wiley +1 more source
Multi–scale modelling of timber–frame structures under seismic loads [PDF]
, 2013 This paper introduces a versatile hysteretic constitutive law, developed for various joints with steel fasteners commonly used in timber structures (nails, screws, staples, 3D connectors of bracket type, punched plates). Compared to previous
Baroth, Juliene +3 more
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Lateral Resistance of Ring-shank Nail Connections in Southern Pine Lumber
, 1998 Ring-shank nails are used in engineered structures with lateral connection design values based on theoretically derived equations which were validated only for common nails.
Bender, D A +3 more
core +1 more source