Results 31 to 40 of about 139,586 (277)
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Defining appropriate limit states for design of timber connections in Australia and New Zealand [PDF]
, 2007 Both Australia and New Zealand design standards for timber structures are in limit states format, but these are first generation soft conversions of previous working stress design standards. It is anticipated that development of a new combined Australian
Crews, K
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Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Test Excavations at the Spanish Governor\u27s Palace, San Antonio, Texas [PDF]
, 1997 Test excavations were carried out in October 1996 by the Center for Archaeological Research of The University of Texas at San Antonio in front of the Spanish Governor\u27s Palace in Military Plaza in downtown San Antonio.
Fox, Anne A.
core +2 more sources
Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source
Multi–scale modelling of timber–frame structures under seismic loads [PDF]
, 2013 This paper introduces a versatile hysteretic constitutive law, developed for various joints with steel fasteners commonly used in timber structures (nails, screws, staples, 3D connectors of bracket type, punched plates). Compared to previous
Baroth, Juliene +3 more
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Reliability Indices for Bolted and Nailed Connections in Wood Structures
, 2001 Recently published test data for bolted and nailed connections was evaluated to assess the structural reliability inherent in current allowable stress design procedures for connections in wood structures.
Bender, Donald A, Pollock, David
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Historic Archeological Investigations at Roberts Cemetery Near Troy, Bell County, Texas [PDF]
, 2014 A preliminary archeological investigation was conducted in 2008 at Roberts Cemetery near Troy, Texas, as part of the Texas Department of Transportation’s planned expansion of Interstate Highway 35.
Abbott, James T. +5 more
core +2 more sources
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
LRFD for Engineered Wood Structures - Connection Behavioral Equations
, 1993 A new design specification for engineered wood structures has been proposed in load and resistance factor design (LRFD) format. This paper provides an overview of the proposed LRFD connections design criteria.
McLain, Thomas E +3 more
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